Linking Environmental Particulate Matter with Genetic Alterations

Cetta, Francesco; Dhamo, A.; Malagnino, G.; Gargiulo, Mauro

doi:10.1289/ehp.0900830

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Asbestos, leas, fly-ash, silica, Carbon monoxide, Sulphur dioxide, welding fumes and coal dust are the main causal agents of respiratory problems in people working in power plants [1,10,11]. However, in many clinical analyses it was found that these particulate agents also lead to genetic mutations which might be passed on to generations and increase fatality of disease [12][13][14]. Thus, in other words, occupational is not localized to the person of exposure, but may also spread it in the family.…”

Section: Introduction Occupational Risks Of Employees In Power Plantsmentioning

confidence: 99%

Determining the Importance of Coaching Methods in Workplace Health and Safety

Son¹,

Albertyn²,

Gerber³

2017

J Ergonomics

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The main objective of the study is to determine the effect and importance of coaching on developing an environment of occupational safety and risks in a workplace. Workplace safety and health constitutes reducing the haphazard arising from one's occupation by implementing safety rules and policies for employees of an organization. Here a qualitative research was conducted to understand various aspect of occupational safety and health (OSH) and the role of coaching. Interview results implicated that coaching of senior employees in the case organization had helped in passing on knowledge, safety management, improved health conditions, reduced accidents and improving the financial expenditures. Thereby it was implicated that coaching on OSH has helped positively in reducing occupational hazards and risks.

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Section: Introduction Occupational Risks Of Employees In Power Plantsmentioning

confidence: 99%

Determining the Importance of Coaching Methods in Workplace Health and Safety

Son¹,

Albertyn²,

Gerber³

2017

J Ergonomics

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“…We have investigated the possibility of a link between exposure to environmental particulate matter and development of lymphoma 5,6 using a new investigational tool, ie, field emission gun-environmental scanning electron microscopy (FEG-ESEM) coupled with energy dispersive spectroscopy (EDS) to determine the chemical composition of the particles identified. We have investigated nanoparticle storage in lymph nodes and involved tissues retrospectively.…”

Section: Introductionmentioning

confidence: 99%

“…However, caution is recommended when interpreting the results of a single case report, as well as those of small studies such as that one by Bick et al, 11 in which small numbers could be responsible for bias in risk calculation. In addition, as our extended studies have already suggested, 5,6,[28][29][30][31][32][33] environmental pollutants are usually present in such a small concentration in the atmosphere that they are unlikely to be solely responsible for the occurrence of malignant disease in the absence of a congenital or inherited predisposition in the host. On the contrary, in the presence of frail predisposed subjects, even small amounts of pollutants could be cofactors for the occurrence of chronic or even malignant diseases.…”

mentioning

confidence: 99%

Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy

Iannitti

Capone

Gatti

et al. 2010

IJN

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Abstract:A 25-year-old man had complained of sudden fever spikes for two years and his blood tests were within the normal range. In 1993, a surgical biopsy of swollen left inguinal lymph nodes was negative for malignancy, but showed reactive lymphadenitis and widespread sinus histiocytosis. A concomitant needle biopsy of the periaortic lymph nodes and a bone marrow aspirate were also negative. In 1994, after an emergency hospital admission because of a sportrelated thoracic trauma, a right inguinal lymph node biopsy demonstrated Hodgkin's lymphoma Stage IVB (scleronodular mixed cell subtype). Although it was improved by chemotherapy, the disease suddenly relapsed, and a further lymph node biopsy was performed in 1998 confirming the same diagnosis. Despite further treatment, the patient died of septic shock in 2004, at the age of 38 years. Retrospective analysis of the various specimens showed intracellular heavy metal nanoparticles within lymph node, bone marrow, and liver samples by field emission gun environmental scanning electron microscopy and energy dispersive spectroscopy. Heavy metals from environmental pollution may accumulate in sites far from the entry route and, in genetically conditioned individuals with tissue specificity, may act as cofactors for chronic inflammation or even malignant transformation. The present anecdotal report highlights the need for further pathologic ultrastructural investigations using serial samples and the possible role of intracellular nanoparticles in human disease.

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Genomic DNA methylation signatures in different tissues after ambient air particulate matter exposure

Guo

et al. 2019

Ecotoxicology and Environmental Safety

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Linking Environmental Particulate Matter with Genetic Alterations

Abstract: Germline mutations of the APC gene in patients with familial adenomatous polyposis associated thyroid carcinoma: results from a European cooperative study.

Cited by 4 publications

References 8 publications

Determining the Importance of Coaching Methods in Workplace Health and Safety

Determining the Importance of Coaching Methods in Workplace Health and Safety

Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy

Genomic DNA methylation signatures in different tissues after ambient air particulate matter exposure

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