Linking Endophytic Fungi to Medicinal Plants Therapeutic Activity. A Case Study on Asteraceae

Caruso, Gianluca; Abdelhamid, Magdi T.; Kalisz, Andrzej; Sękara, Agnieszka

doi:10.3390/agriculture10070286

Cited by 52 publications

(29 citation statements)

References 122 publications

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“…Several studies investigated the microbiome of medicinal plants (MPs), e.g., Origanum vulgare ( Pontonio et al, 2018 ; Castronovo et al, 2020 ), Matricaria chamomilla, and Calendula officinalis ( Köberl et al, 2019 ) as well as Salvia miltiorrhiza ( Chen et al, 2018 ; Huang et al, 2018 ). MPs are characterized by a high variety of unique secondary metabolites and many endophytes producing pharmacologically active substances ( Köberl et al, 2013 ; Golinska et al, 2015 ; Ivanova et al, 2016 ; Rahman et al, 2017 ; Caruso et al, 2020 ; Gupta et al, 2020 ; Teimoori-Boghsani et al, 2020 ). Thus, beside the potential impact of the plant microbiome on pathogen resistance and general fitness evidence has accumulated that the microbiome has a significant impact on the production of secondary metabolites of MPs ( Köberl et al, 2013 ; Schmidt et al, 2014 ; Jia et al, 2016 ; Huang et al, 2018 ; Pacifico et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

et al. 2021

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In the recent past many studies investigated the microbiome of plants including several medicinal plants (MP). Microbial communities of the associated soil, rhizosphere and the above-ground organs were included, but there is still limited information on their seasonal development, and in particular simultaneous investigations of different plant organs are lacking. Many studies predominantly addressed either the prokaryotic or fungal microbiome. A distinction of epi- and endophytic communities of above-ground plant organs has rarely been made. Therefore, we conducted a comprehensive investigation of the bacterial and fungal microbiome of the MP Achillea millefolium and studied the epi- and endophytic microbial communities of leaves, flower buds and flowers between spring and summer together with the microbiome of the associated soil at one location. Further, we assessed the core microbiome of Achillea from four different locations at distances up to 250 km in southern Germany and Switzerland. In addition, the bacterial and fungal epi- and endophytic leaf microbiome of the arborescent shrub Hamamelis virginiana and the associated soil was investigated at one location. The results show a generally decreasing diversity of both microbial communities from soil to flower of Achillea. The diversity of the bacterial and fungal endophytic leaf communities of Achillea increased from April to July, whereas that of the epiphytic leaf communities decreased. In contrast, the diversity of the fungal communities of both leaf compartments and that of epiphytic bacteria of Hamamelis increased over time indicating plant-specific differences in the temporal development of microbial communities. Both MPs exhibited distinct microbial communities with plant-specific but also common taxa. The core taxa of Achillea constituted a lower fraction of the total number of taxa than of the total abundance of taxa. The results of our study provide a basis to link interactions of the microbiome with their host plant in relation to the production of bioactive compounds.

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Section: Introductionmentioning

confidence: 99%

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

et al. 2021

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“…The roots or rhizomes of Zingiberaceae play an important role as reservoirs of metabolites and nutrition for initiating and promoting the metabolism of endophytic fungi. The great diversity of endophytic fungi in a plant species may be explained by the differences in spatio-temporal distribution of host plants across regions or the wide range of colonization niches occupied by certain rhizospheric fungi 22 . Also, plants of a species at different stages of life-cycle may harbor distinct endophytic fungal communities over time.…”

Section: Resultsmentioning

confidence: 99%

Antagonistic Activity of Endophytic Fungi Isolated from Globba patens Miq. Rhizome against Human Pathogenic Bacteria

Lutfia¹,

Munir²,

Yurnaliza³

et al. 2021

J Pure Appl Microbiol

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The emergence of bacterial infections caused by resistant strains poses a threat to the development of new antibiotics. The majority of antibiotics being produced has been accelerated through the finding of newly reported natural products, especially those originated and produced by biological sources. Endophytic fungi residing in medicinal plants may be regarded as potential sources and encourage the exploration of more plant species for their antimicrobial activity. Our current study reports on the assemblage of endophytic fungi that colonize the rhizomes, using Globba patens a representative of Zingiberaceous species from North Sumatra. Twenty-six fungal morphotypes were obtained and differentiated by their morphological features. Each isolate was tested against human pathogenic bacteria namely Staphylococcus aureus ATCC® 29213™, Methicillin-resistant S. aureus (MRSA) ATCC® 43300™, Escherichia coli ATCC® 25922™, and Enteropathogenic E. coli (EPEC) K11 in a dual culture assay. The results revealed that the majority of fungal isolates were strong antagonists against S. aureus and E. coli but not against MRSA and EPEC. Isolate Gp07 was the most potential fungus with a wide range of antibacterial activities and was subjected to further species-level identification based on its morphological characteristics and DNA sequence in the ITS-rDNA region. The isolate Gp07 was identified as Colletotrichum siamense, yet the presence of C. siamense in the rhizome of G. patens is not fully understood while possibly being characterized as the antibiotics-producing agent in the future.

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“…Hence, the Taxol from T. andreanae can preferably stand promising over its host plant due to ease of exploration by fermentation and production [ 26 ]. Furthermore, studies in the literature on some medicinal plants and endophytes in the synthesis of bioactive compounds with more emphasis on plant species and organs as sources of bioactive metabolites have been reported [ 27 , 28 ].…”

Section: Bioactive Compounds From Medicinal Plantsmentioning

confidence: 99%

Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

Adeleke

Babalola

2021

JoF

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Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.

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Linking Endophytic Fungi to Medicinal Plants Therapeutic Activity. A Case Study on Asteraceae

Cited by 52 publications

References 122 publications

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

Antagonistic Activity of Endophytic Fungi Isolated from Globba patens Miq. Rhizome against Human Pathogenic Bacteria

Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review

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