Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools

Expert consensus report on lipid mediators: Role in resolution of inflammation and muscle preservation

“…51 1.2.4 | Neurological diseases other than MS Any advances within the field of MS may also have ramifications for other neurological fields. For instance, impaired cognition is a major clinical symptom of MS, being present in more than 50% of patients, 52 and neuroinflammation is also thought to play a causal role in this and other disorders with cognitive and/or motor symptoms, including other neurodegenerative diseases like AD and PD, as well as perioperative neurocognitive disorders. 53 Indeed, neuroinflammation can often complicate postoperative recovery, and this has been reflected in postoperative changes in lipid mediator levels from cerebrospinal fluid (CSF) samples.…”

Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis

“…As noted above, MS-related cognitive impairments are due in part to neuroinflammation, demyelination, and neurodegeneration ( Barros and Fernandes, 2021 , DeLuca et al, 2015 ), making therapeutic strategies that target these processes of interest ( Pierson and Griffith, 2006 ). Cardiovascular exercise is one intervention that has been promoted as a critical component of cognitive rehabilitation in MS, and which may have disease-modifying potential ( Motl and Sandroff, 2018 , Motl et al, 2017 , Ploughman, 2008 ).…”

MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

“…PLWH also exhibit hypersensitivity to environmental insults, e.g., infectious agents and medications (prophylactics, antibiotics, drugs to treat infections, and antiretrovirals 4 ). The mechanisms driving these changes is not known, but cognitive deficits have been linked to neuroinflammation in several diseases associated with neural insults 5,6 , including HIV [7][8][9][10] .…”