MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

Young, Jared W.; Barback, Christopher V.; Stolz, Louise A; Groman, Stephanie M.; Vera, David R.; Hoh, Carl K.; Kotta, Kishore K.; Minassian, Arpi; Powell, Susan B.; Brody, Arthur L.

doi:10.1016/j.pscychresns.2022.111445

Psychiatry Research: Neuroimaging

2022

DOI: 10.1016/j.pscychresns.2022.111445

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MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

Jared W. Young

Christopher V. Barback

Louise A Stolz

et al.

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Cited by 4 publications

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“…Third, blocking experiment using a nonradioactive FEPPA or other nonradioactive TSPO ligand was not performed in the current study. Nonetheless, [ 18 F]FEPPA is a relatively popular ligand that had been used in many preclinical and clinical studies [75,76], including and not limited to psychiatric disorders [62,77]. Various studies have also demonstrated that [ 18 F]FEPPA reliably binds to TSPO in the brain [78][79][80].…”

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confidence: 99%

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

Cheng

Guo

et al. 2022

Mol Imaging

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Background. [18F]FEPPA is a potent TSPO imaging agent that has been found to be a potential tracer for imaging neuroinflammation. In order to fulfill the demand of this tracer for preclinical and clinical studies, we have developed a one-pot automated synthesis with simplified HPLC purification of this tracer, which was then used for PET imaging of neuroinflammation in fine particulate matter- (PM2.5-) exposed rats. Results. Using this automated synthesis method, the RCY of the [18F]FEPPA was 38 ± 4 % ( n = 17 , EOB) in a synthesis time of 83 ± 8 min from EOB. The radiochemical purity and molar activities were greater than 99% and 209 ± 138 GBq/μmol (EOS, n = 15 ), respectively. The quality of the [18F]FEPPA synthesized by this method met the U.S. Pharmacopoeia (USP) criteria. The stability test showed that the [18F]FEPPA was stable at 21 ± 2 °C for up to 4 hr after the end of synthesis (EOS). Moreover, microPET imaging showed that increased tracer activity of [18F]FEPPA in the brain of PM2.5-exposed rats ( n = 6 ) were higher than that of normal controls ( n = 6 ) and regional-specific. Conclusions. Using the improved semipreparative HPLC purification, [18F]FEPPA has been produced in high quantity, high quality, and high reproducibility and, for the first time, used for PET imaging the effects of PM2.5 in the rat brain. It is ready to be used for imaging inflammation in various clinical or preclinical studies, especially for nearby PET centers without cyclotrons.

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confidence: 99%

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

Cheng

Guo

et al. 2022

Mol Imaging

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HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats

Namba

Phillips

Chen

et al. 2023

Addiction Neuroscience

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Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions

Namba

Xie

Barker

2023

Brain, Behavior, and Immunity

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MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

Cited by 4 publications

References 69 publications

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats

Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions

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MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

Cited by 4 publications

References 69 publications

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [18F]FEPPA: A Feasibility Study

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [18F]FEPPA: A Feasibility Study

HIV gp120 impairs nucleus accumbens neuroimmune function and dopamine D3 receptor-mediated inhibition of cocaine seeking in male rats

Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions

Contact Info

Product

Resources

About

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study

Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [¹⁸F]FEPPA: A Feasibility Study