Linkage of microbiota and osteoporosis: A mini literature review

Yatsonsky, David; Pan, Karen; Shendge, Vithal B; Liu, Jiayong; Ebraheim, Nabil A.

doi:10.5312/wjo.v10.i3.123

Cited by 44 publications

(28 citation statements)

References 32 publications

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“…Microbiome is undoubtedly an important determinant of many aging-related pathological states. Among them, there are chronic inflammation [22], neurodegeneration [23], sarcopenia [24], osteoporosis [25], obesity, metabolic syndrome and type 2 diabetes [26,27], cardiovascular disease [28] and cancer [29]. Therefore, ageassociated changes in microbiota composition and function seem to be very important in the biogerontological context.…”

Section: Discussionmentioning

confidence: 99%

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

et al. 2020

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Background: Gut microbiota plays an important role in physiological and pathological processes of the host organism, including aging. Microbiota composition was shown to vary significantly throughout the life course. Agerelated changes in the composition of microbiota were reported in several human studies. In present study, agerelated dynamics of phylogenetic profile of gut microbiota was investigated in 1550 healthy participants from Ukrainian population. Results: Significant changes in the microbiota composition determined by qRT-PCR at the level of major microbial phyla across age groups have been observed. The relative abundance of Actinobacteria and Firmicutes phyla increased, while that of Bacteroidetes decreased from childhood to elderly age. Accordingly, the Firmicutes/ Bacteroidetes (F/B) ratio was shown to significantly increase until elder age. In both sexes, odds to have F/B > 1 tended to increase with age, reaching maximum values in elder age groups [OR = 2.7 (95% CI, 1.2-6.0) and OR = 3.7 (95% CI, 1.4-9.6) for female and male 60-69-year age groups, respectively, compared to same-sex reference (0-9year) age groups]. Conclusions: In conclusion, data from our study indicate that composition of the human intestinal microbiota at the level of major microbial phyla significantly differs across age groups. In both sexes, the F/B ratio tends to increase with age from 0-9-year to 60-69-year age groups. Further studies are needed for a better understanding of mechanisms underlying age-related dynamics of human microbiota composition.

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Section: Discussionmentioning

confidence: 99%

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

et al. 2020

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“…The other topic which deserves more attention is HPI-associated dysregulation of gut microbiota [ 239 , 606 , 653 , 654 , 655 , 656 , 657 , 658 , 659 , 660 , 661 , 662 , 663 , 664 , 665 , 666 , 667 ], a phenomenon described also in animal models (infected Mongolian gerbils [ 668 ]) and thought to be due mainly to gut immunopathological/inflammatory responses and suppressed gastric acid secretion following chronic/atrophic gastritis or use of acid-suppressive drugs. Gut dysbiosis by affecting various biological processes contributes to the pathogenesis of OP [ 669 , 670 , 671 , 672 , 673 , 674 , 675 , 676 , 677 , 678 , 679 , 680 , 681 , 682 , 683 , 684 , 685 , 686 , 687 , 688 , 689 , 690 , 691 , 692 , 693 , 694 , 695 , 696 , 697 , 698 , 699 ] as well as to numerous other extra-digestive system diseases associated with OFs [ 700 , 701 , 702 ,…”

Section: Clinical Implications and Recommendationsmentioning

confidence: 99%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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“…The inclusion criteria for the osteoporosis group included (1) patients who were diagnosed with osteoporosis by dual-energy x-ray absorptiometry or with osteoporotic fractures by imaging and (2) non-violent fractures.…”

Section: Research Subjectsmentioning

confidence: 99%

“…As a mammal, humans have an incredibly large number of microbes living on and inside our bodies and a complex community of symbiotic bacteria (1).These microorganisms play an important role in the physiological activities of the human body. The largest microecosystem in the human body is the intestinal tract (2).…”

Section: Introductionmentioning

confidence: 99%

The role of Bacillus acidophilus in osteoporosis and its roles in osteocyte proliferation and differentiation

Chen

Dong

Wang

et al. 2019

Preprint

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The microbes play an important role to physiological activities of human. Osteoporosis is one of the most closely relationship diseases with the elderly. In recent years, the studies found that gut microbiota can cause osteoporosis. These microbes may affect activity of osteoclasts and osteoblasts to affect bone metabolism. We selected 5 health people and 10 osteoporosis patients and found that the diversity of gut microbiota in osteoporosis patients are decreased and imbalance with lower abundance of lactobacillus and butylic acid bacteria, meanwhile, 25-hydroxyitamin D and procollagen type I N-terminal peptide (PINP) of osteoporosis patient was significantly lower than the normal group. The proliferation, differentiation and maturity of osteoblasts MC3T3-E1 cells was stimulated, the activity of alkaline phosphatase, concentration of osteocalcin and the expression of RUNX2, WNT2 and CTNNB1 was improved by supernatant of lactobacillus acidophilus and butanoic acids, however, the proliferation, differentiation and maturity, the expression of RANK,WNT2 and CTNNB1 in osteoclasts RAW 264.7 cells was suppressed. There is not a similar significant effect by lactobacillus rhamnosus treatment.

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Linkage of microbiota and osteoporosis: A mini literature review

Cited by 44 publications

References 32 publications

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

The role of Bacillus acidophilus in osteoporosis and its roles in osteocyte proliferation and differentiation

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