Linkage between ζ-potential and electron donicity of charged polar surfaces 1. Implications for the mechanism of flocculation of particle suspensions with plurivalent counterions

Wu, W.; Giese, R. F.; Oss, Carel J. van

doi:10.1016/0927-7757(94)80122-3

Cited by 104 publications

(41 citation statements)

References 28 publications

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“…At least, electrostatic arguments would aim to this conclusion. Some authors, 28 however, have found flocculation phenomena in situations in which measured -potential was still sufficient to ensure electrostatic repulsion between colloidal particles. Such a coagulation was justified by means of hydrophobic attraction.…”

Section: Resultsmentioning

confidence: 99%

Hofmeister Effects in the Stability and Electrophoretic Mobility of Polystyrene Latex Particles

et al. 2003

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Specific ionic effects on numerous solid-aqueous solution interfaces have usually been ranked in the socalled Hofmeister series. Ion specificity has experimentally been manifested in many ways. In this work, the colloidal stability and electrophoretic mobility of three different polystyrene latex samples are analyzed in the presence of different electrolytes. The effects on their colloidal stability and electrokinetic behavior provoked by four anions (SO 4 2-, Cl -, NO 3 -, and SCN -) and three cations (NH 4 + , Na + , and Ca 2+ ) located in different positions in the Hofmeister series are shown. Some of these ions specifically modified the pair potential interaction of the colloidal particles yielding results not explained by the Derjaguin, Landau, Verwey, and Overbeek (DLVO) theory. A modification in the repulsive electrostatic term of this theory is then proposed to consider the ionic specificity. In addition, general but qualitative explanations about the subjacent mechanisms involved in the Hofmeister effects are also summarized.

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Section: Resultsmentioning

confidence: 99%

Hofmeister Effects in the Stability and Electrophoretic Mobility of Polystyrene Latex Particles

et al. 2003

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“…Biophysical assays used to measure solution mediated properties like k D (self-association) and zeta potential (colloidal stability) show a correlation with propensity to aggregate at 40 C. Models using colloidal systems suggest charge-charge interactions play a crucial role in particle flocculation and aggregation. 23 Saluja et al showed a positive correlation between the second virial coefficient (B 2 ) and k D values in predicting solution conditions that promote heat-and agitation-induced aggregation for an IgG2 mAb. 24 We observe this dependency for mAbs with low net effective surface charge (i.e., less colloidally stable), which tend to aggregate at 40 C (Fig.…”

Section: Discussionmentioning

confidence: 99%

A comparison of biophysical characterization techniques in predicting monoclonal antibody stability

Thiagarajan

Semple

James

et al. 2016

mAbs

103

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With the rapid growth of biopharmaceutical product development, knowledge of therapeutic protein stability has become increasingly important. We evaluated assays that measure solution-mediated interactions and key molecular characteristics of 9 formulated monoclonal antibody (mAb) therapeutics, to predict their stability behavior. Colloidal interactions, self-association propensity and conformational stability were measured using effective surface charge via zeta potential, diffusion interaction parameter (k D ) and differential scanning calorimetry (DSC), respectively. The molecular features of all 9 mAbs were compared to their stability at accelerated (25 C and 40 C) and long-term storage conditions (2-8 C) as measured by size exclusion chromatography. At accelerated storage conditions, the majority of the mAbs in this study degraded via fragmentation rather than aggregation. Our results show that colloidal stability, self-association propensity and conformational characteristics (exposed tryptophan) provide reasonable prediction of accelerated stability, with limited predictive value at 2-8 C stability. While no correlations to stability behavior were observed with onset-of-melting temperatures or domain unfolding temperatures, by DSC, melting of the Fab domain with the C H 2 domain suggests lower stability at stressed conditions. The relevance of identifying appropriate biophysical assays based on the primary degradation pathways is discussed.

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“…Interaction energy, AGI~t, (kT) of the clay particle immersed in aqueous solution at equilibrium distance eo = 0.157 nm, ionic strength I"/2 = 0.015 and 20~ tials indicates that the stability of the stable suspensions is mostly related to the AB repulsive interaction, which is the direct result of the large surface electron donicity (~/~) of these clays (Table 4). Flocculation is largely caused by attractive AB (hydrophobic) interactions, and the van der Waals forces only make a secondary contribution (Table 4; see also Wu et al, 1994).…”

Section: Colloidal Stabilitymentioning

confidence: 99%

Baseline Studies of the Clay Minerals Society Source Clays: Colloid and Surface Phenomena

2001

Clays and clay miner.

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The interface between the surfaces of clay minerals and other materials (aqueous solution, organic moieties, biomolecules, etc.) is of great importance to many geological, technological and biological processes. The examination of the structure and composition of mineral surfaces is advancing rapidly. However, the crystal structure of a mineral is only part of the information needed to understand the activity of the surface; we still do not fully understand the chemical and physical interactions at the surface or interface. One very powerful methodology for the study of surfaces and interfacial interactions is the determination of the thermodynamic properties of the surface. It became possible in the late 1980s to determine quantitatively the apolar and polar surface-tension components and parameters of liquids and solids (van Oss et al., 1988; van Oss, 1994), and the experimental techniques necessary for obtaining surface free-energy components of minerals, and particularly of colloid-sized minerals, are also a recent development (Costanzo eta!., 1990; van Oss et al., 1990, 1992; Giese et al., 1991).

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Linkage between ζ-potential and electron donicity of charged polar surfaces 1. Implications for the mechanism of flocculation of particle suspensions with plurivalent counterions

Cited by 104 publications

References 28 publications

Hofmeister Effects in the Stability and Electrophoretic Mobility of Polystyrene Latex Particles

Hofmeister Effects in the Stability and Electrophoretic Mobility of Polystyrene Latex Particles

A comparison of biophysical characterization techniques in predicting monoclonal antibody stability

Baseline Studies of the Clay Minerals Society Source Clays: Colloid and Surface Phenomena

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