Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa.

Report of the committee on the genetic constitution of chromosome 1

“…If RP is on chromosome 1, it is probably distal to Rh because its close linkage with PGMl has been excluded (Field et al, 1982). Other suggestive positive lod scores are those for a dominant form of epidermolysis bullosa with Fy.…”

Identification of the RP1 and RP10 (IMPDH1) Genes Causing Autosomal Dominant RP

“…All of the RP1 families so far described have relatively late onset retinitis pigmentosa, usually described as type 2 or "R" type with regional loss of both rod and cone photoreceptor activities (Field et al, 1982;Inglehearn et al, 1999;Xu et al, 1996). There is wide variation in severity and age of onset among affected members of large RP1 families, with a few reported instances of unaffected "carriers" over age 50.…”

Glutamate Pyruvate Transaminase Null Allele (GPT°) in the Navajo

“…Be cause the retinitis pigmentosa inheritance occurred through individual 1-2, other family members of in dividual 1-1 were not studied. The full pedigree and results of linkage analysis in this family are reported elsewhere [ Field et al, 1982].…”