Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE−/− mice fed high-fat diet

Marungruang, Nittaya; Kovalenko, T. M.; Osadchenko, I.; Voss, Ulrikke; Huang, Fang; Burleigh, Stephen; Ушакова, Г. А.; Skibo, G. G.; Nyman, Margareta; Prykhodko, Olena; Hållenius, Frida Fåk

doi:10.1080/1028415x.2018.1536423

Cited by 26 publications

(20 citation statements)

References 50 publications

(62 reference statements)

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“…Lingonberry supplementation prevented these effects. These findings are supported by previous studies with freeze-dried lingonberries and lingonberry extract on a longer follow-up [21][22][23]25,35] while bilberry supplementation did not have any effect on PLOS ONE blood glucose levels [36]. Anthocyanins in the lingonberry powder could contribute to the beneficial effects on glucose tolerance as anthocyanin-rich supplements from Montmorency tart cherries have been reported to have insulin lowering effects in patients with metabolic syndrome [37] and purified blueberry anthocyanins reduced blood glucose levels in a murine model of obesity [38].…”

Section: Discussionsupporting

confidence: 88%

“…Lingonberry (Vaccinium vitis-idaea L.) has been reported to have promising health-beneficial effects and anti-inflammatory properties in experimental models [16][17][18][19]. Lingonberries / lingonberry extracts were found to exhibit antidiabetic potential in various in vitro tests [20] and beneficial metabolic effects in mice exposed to high-fat diet [21][22][23][24][25]. Lingonberries are rich in dietary polyphenols with high antioxidant activities [16,[26][27][28] and contain also essential omega-3 fatty acids [29] and plant sterols [30,31], which may contribute to their healthpromoting effects.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

et al. 2020

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Obesity is a constantly increasing health problem worldwide. It is associated with a systemic low-grade inflammation, which contributes to the development of metabolic disorders and comorbidities such as type 2 diabetes. Diet has an important role in the prevention of obesity and its adverse health effects; as a part of healthy diet, polyphenolrich berries, such as lingonberry (Vaccinium vitis-idaea L.) have been proposed to have health-promoting effects. In the present study, we investigated the effects of lingonberry supplementation on high-fat diet induced metabolic and inflammatory changes in a mouse model of obesity. Thirty male C57BL/6N mice were divided into three groups (n = 10/ group) to receive low-fat (LF), high-fat (HF) and lingonberry-supplemented high-fat (HF +LGB) diet for six weeks. Low-fat and high-fat diet contained 10% and 46% of energy from fat, respectively. Lingonberry supplementation prevented the high-fat diet induced adverse changes in blood cholesterol and glucose levels and had a moderate effect on the weight and visceral fat gain, which were 26% and 25% lower, respectively, in the lingonberry group than in the high-fat diet control group. Interestingly, lingonberry supplementation also restrained the high-fat diet induced increases in the circulating levels of the proinflammatory adipocytokine leptin (by 36%) and the inflammatory acute phase reactant serum amyloid A (SAA; by 85%). Similar beneficial effects were discovered in the hepatic expression of the inflammatory factors CXCL-14, S100A10 and SAA by lingonberry supplementation. In conclusion, the present results indicate that lingonberry supplementation significantly prevents high-fat diet induced metabolic and inflammatory changes in a murine model of obesity. The results encourage evaluation of lingonberries as a part of healthy diet against obesity and its comorbidities.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

et al. 2020

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“…The mice fed wLB and an insoluble fraction (insLB) showed higher plasma levels of HDL cholesterol and triglyceride levels than the HFD control. Both wLB and insLB also changed the cecal microbiota composition by decreasing the relative abundance of Mucispillirum and increasing Akkermansia [ 44 ]. Male C57BL/6 J mice fed a high-fat/high-sucrose (HFHS) diet and treated with lingonberry extract for 8 weeks had lower fasting and postprandial hyperinsulinemia, improved insulin sensitivity, and enhanced hepatic insulin clearance.…”

Section: Biological Activity and Health-promoting Effectsmentioning

confidence: 99%

Lingonberry (Vaccinium vitis-idaea L.) Fruit as a Source of Bioactive Compounds with Health-Promoting Effects—A Review

Kowalska¹

2021

IJMS

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Berries, especially members of the Ericaceae family, are among the best dietary sources of bioactive compounds with beneficial health effects. The most popular berries are in the genus Vaccinium, such as bilberry (Vaccinium myrtillus), cranberry (Vaccinium macrocarpon, V. oxycoccos), and blueberry (Vaccinium corymbosum). Lingonberry (Vaccinium vitis-idaea) is less prevalent in the daily human diet because they are collected from the wild, and plant breeding of lingonberry is still on a small scale. Lingonberries are classed as “superfruits” with the highest content of antioxidants among berries and a broad range of health-promoting effects. Many studies showed various beneficial effects of lingonberries, such as anti-inflammatory, antioxidant, and anticancer activities. Lingonberries have been shown to prevent low-grade inflammation and diet-induced obesity in diabetic animals. Moreover, lingonberry intake has been associated with a beneficial effect on preventing and treating brain aging and neurodegenerative disorders. The consumption of berries and their health-promoting activity is a subject receiving a great deal of attention. Many studies investigated the natural compounds found in berries to combat diseases and promote healthy aging. This article’s scope is to indicate the potential beneficial effect of lingonberry consumption on health, to promote well-being and longevity.

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“…Tremendous evidence has indicated that F&V have manipulating effects on gut microbiota via in vivo and in vitro studies, in animal models or among human volunteers (Klinder et al, 2016;Zhu et al, 2016;Henning et al, 2017;Vivarelli et al, 2017;Choi et al, 2018;Marungruang et al, 2018;Cui et al, 2019;Nagano & Yano, 2019;Wu et al, 2019aWu et al, , 2019bWu et al, , 2019cWu et al, , 2019d. Subsequently, more in-depth investigations on phytochemicals have been carried out, and its correlation with gut microbiota has been explored extensively in recent years (Liu et al, 2018b;Liu et al, 2018a;Pansai et al, 2019;Wei et al, 2019;Wu et al, 2019;Xu et al, 2020;Zhou et al, 2020) (Table 1).…”

Section: Gut Microbiota Modulators In Fandvmentioning

confidence: 99%

“…As a leading fruit group containing high level of polyphenol, berries have been proved to nourish the growth of gut Lactobacillus, Bifidobacterium, Ruminococcus and Akkermansia (Marungruang et al, 2018;Bao et al, 2019;Cheng et al, 2020;Zhou et al, 2020). Marungruang et al (2018) observed the regulative effects of lingonberries on gut microbiota in mice fed with high-fat diet, and reported reduced gut inflammatory properties and improved metabolic and brain function. Furthermore, mounting in vitro and in vivo evidence is supporting the regulative effects of fruit and vegetable polyphenols on gut microbiota.…”

Section: Polyphenolsmentioning

confidence: 99%

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Lin

Bordiga

Brennan

et al. 2021

Int J of Food Sci Tech

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The objective of the current review was to systematically investigate health-promoting manipulating effects of fruits and vegetables (F&V) on the gut microbiota. The function of gut microbes was found to promote health effects in the host by scavenging free radicals, modulating immune system, alleviating obesity and diabetes. Masters that manipulate the gut microbiota are the phytochemicals within specific types of F&V, where polyphenols account for the largest proportion, along with alkaloids, terpenes, nitrogen-containing compounds, polysaccharides and natural pigments present in plants. These bioactive compounds exhibit the regulative influences on gut microorganisms characterised by rescuing dysbiosis of gut microbiota, increasing/decreasing microbial abundance, restructuring microbial composition, and rebalancing gut microbial homeostasis. This review indicated that F&V extracts targeting at gut microbiota could be a new scope of ingredient selection in the field of functional food especially for amelioration of dysfunction of intestinal ecosystem.

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Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE−/− mice fed high-fat diet

Abstract: Prykhodko & Frida Fåk Hållenius (2020) Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE−/− mice fed high-fat diet,

Cited by 26 publications

References 50 publications

Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

Lingonberry (Vaccinium vitis-idaea L.) Fruit as a Source of Bioactive Compounds with Health-Promoting Effects—A Review

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

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