Linfoma primário do sistema nervoso central

Bellesso, Marcelo; Bizzetto, Renata; Pereira, Juliana; Beitler, Beatriz; Pracchia, Luís Fernando; Chamone, Dalton A. S.

doi:10.1590/s1516-84842008000100013

Cited by 4 publications

(8 citation statements)

References 37 publications

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“…Acquired or congenital immunodeficiency is the best-established risk factor, and the disease usually presents as a single tumor located mainly in the frontal lobes (20%-43%) and the basal nuclei (9%-13%) [4].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 90% of PCNSL cases are diffuse large B-cell lymphomas, and the remaining 10% are Tcell Burkitt or indolent lymphomas [3]. These tumors can manifest as focal lesions, which may be single, multiple, or even disseminated diseases [4]. Differential diagnoses should be made between these lesions and several diseases, both systemic and focal, such as multiple sclerosis, sarcoidosis, and gliomas.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse Large B-Cell Lymphoma in Bilateral Basal Ganglia: A Rare Case Report

Silva

Gomes

Tenório

et al. 2022

Cureus

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Primary central nervous system lymphoma (PCNSL) may affect the basal nuclei of the brain. The most common type is diffuse large B-cell lymphoma. This is a case report of an adolescent with rare bilateral lymphoma in the basal ganglia. A male patient aged 16 years had a clinical picture of rapid progression to motor aphasia, dysphagia, and right hemiplegia. Magnetic resonance imaging (MRI) of the skull, along with spectroscopy, indicated lymphoproliferative or neoplastic disease. A biopsy confirmed diffuse large B-cell lymphoma. However, the patient died before starting the definitive treatment. PCNSL is infrequent in the pediatric population, but it has a better prognosis in this age group, especially when diagnosed early. It affects immunodeficient patients more often. In addition to MRI, spectroscopy and positron-emission tomography help clarify the diagnosis. Biopsy is a gold standard for diagnosis, leading to the appropriate initiation of chemotherapy and radiotherapy treatment. PCNSL is rare in young patients. With an early diagnosis, better therapeutic planning is possible. Unfortunately, in the present case, the diagnosis was late, and the patient had an unfavorable outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma in Bilateral Basal Ganglia: A Rare Case Report

Silva

Gomes

Tenório

et al. 2022

Cureus

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“…Long et al (2001) relataram um caso semelhante. Em humanos, a lesão intracraniana única é a apresentação mais comum em imunocompetentes (Bellesso et al, 2008).…”

Section: Discussão E Conclusõesunclassified

“…Vet. Zootec., v.64, n.6, p.1497-1503, 2012 periventriculares, vítreas ou em medula espinhal intradural (Bellesso et al, 2008).…”

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“…O envolvimento meníngeo em humanos, caracterizado por células neoplásicas no LCR ou nódulos em raízes nervosas, ocorre em 25% dos casos de linfoma primário do sistema nervoso central. Em menos de 1% dos casos há envolvimento primário da medula espinhal (Bellesso et al, 2008). Em cães, 70 a 75% dos linfomas são de células B, 20 a 25 % são de células T e menos de 5% são classificados como não T e não B (Morrison, 2005).…”

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Linfoma primário de células T no líquido cefalorraquidiano de cão: relato de caso

Moraes¹,

Romão²,

Borges

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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3 Médico veterinário autônomo RESUMO Relata-se o diagnóstico de linfoma primário no sistema nervoso central em um cão Labrador Retrievier, de 10 anos de idade, que apresentava episódios convulsivos, incoordenação nos membros posteriores, head tilt, ataxia e sensibilidade diminuída no lado esquerdo. Constataram-se alterações laterais esquerdas, como ausências de propriocepção e de posicionamento tátil, alterações posteriores nas provas de carrinho de mão e de reação ao pulo e diminuição da extensão da postura e hemilocomoção. No líquido cefalorraquidiano (LCR), houve predomínio de linfócitos atípicos, caracterizados pela presença de anisocitose e anisocariose, nucléolos evidentes e anisonucleose, basofilia e microvacuolização citoplasmáticas, mitoses atípicas e corpúsculos linfoglandulares, compatíveis com linfoma, confirmado pelo exame histológico e imunocitoquímico, o qual revelou origem T, com expressão CD3+ e CD79-. A tomografia computadorizada não foi conclusiva e evidenciou diversas áreas hipodensas e intensificação de contraste na região de sulcos e giros do parênquima encefálico. A coleta do LCR foi essencial na rapidez do diagnóstico definitivo, indicando a natureza rara desta lesão primária.

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Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

Medeiros,

Sequeira,

Mendes

et al. 2023

European Journal of Case Reports in Internal Medicine

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Central nervous system (CNS) lymphoma is a rare and aggressive primary neoplasm that comprises a small proportion of brain tumours and non-Hodgkin lymphomas. We present a case report of a 64-year-old woman with CNS lymphoma, who exhibited cognitive changes, weight loss and neurological symptoms. Imaging scans revealed multiple lesions in the brain and thrombosis in the venous sinuses. A diagnosis of diffuse large B-cell lymphoma of the CNS was confirmed through histological examination. The patient underwent treatment with corticosteroids and chemotherapy, but experienced clinical deterioration with thrombocytopenia and disease progression. Despite efforts to manage complications and provide targeted therapy, the patient passed away. Primary CNS lymphoma typically responds well to chemotherapy, and prognostic factors such as age and functional status play a significant role in patient outcomes. However, complications such as thromboembolism pose challenges during treatment due to the hypercoagulable state induced by chemotherapy agents. The pathophysiology of thromboembolic events in the context of malignancy remains uncertain but may involve direct tumour compression, vascular invasion and alterations in coagulation factors. The diagnostic process for CNS lymphoma can be complex, and the information obtained from cerebrospinal fluid analysis, including flow cytometry, may be limited in cases with low cell counts. Ongoing research exploring genetic tests and biomarkers shows promise for improving diagnostic accuracy in such cases. This case underscores the need for comprehensive management strategies that address both the neoplasm and its associated complications, to optimise patient outcomes.

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Linfoma primário do sistema nervoso central

Cited by 4 publications

References 37 publications

Diffuse Large B-Cell Lymphoma in Bilateral Basal Ganglia: A Rare Case Report

Diffuse Large B-Cell Lymphoma in Bilateral Basal Ganglia: A Rare Case Report

Linfoma primário de células T no líquido cefalorraquidiano de cão: relato de caso

Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report

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