Linfoma intravascular tratado con anticuerpos monoclonales anti CD20: Descripción de un caso clínico

Abstract

We report a 78 year old male with prostatism, that was subjected to a prostate biopsy. The pathological study showed a microvascular lymphocytic infiltration. Four months later, the patients presented with reduced alertness, cough, dyspnea, fever and elevation of lactic dehydrogenase and erythrocyte sedimentation rate. Chest and abdominal CAT scans, bone marrow aspirate, protein electrophoresis and prostate specific antigen were normal. A re-evaluation of prostate biopsy showed an intravascular lymphoid infiltration, positive for CD45 and CD20, compatible with the diagnosis of intravascular lymphoma. Chemotherapy was started, but it was not tolerated by the patient and the response was partial. Therefore, treatment with monoclonal antibodies anti CD20 (Rituximab) was started. The tumor had a complete and prolonged (24 months) remission after the treatment

Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

“…Neoplastic cells are rarely seen in bone marrow and peripheral blood smears and so IVLBCL is very difficult to diagnose; most of the cases reported have been confirmed by autopsy or cutaneous biopsies [ 6 ]. IVLBCL diagnosed in prostate specimens is extremely rare in the literature, usually reported as single cases; to the best of our knowledge, this is the 10th such case reported [ 1 , 7 , 8 , 9 , 10 , 11 , 12 ]. Furthermore, none of the patients in the study by Murase et al, with a large series of 96 patients, were diagnosed with prostatic involvement, indicating the rarity of infiltration in this site [ 6 ].…”