Linfoma canino: clínica, hematologia e tratamento com o protocolo de Madison-Wisconsin

Cápua, Maria Luísa Buffo de; Coleta, Flávia Eiras Dela; Canesin, Ana Paula Massae Nakage; Godoy, Aline Vieira; Calazans, Sabryna Gouveia; Miotto, Mariana Rodrigues; Daleck, Carlos Roberto; Santana, Áureo Evangelista

doi:10.1590/s0103-84782011005000090

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…35 Leukocytosis is often detected in dogs with lymphoma, reflecting the inflammatory condition related to the tumor. 36 After chemotherapy, leukocytosis was not observed in treated animals, suggesting the reduction in Figure 2 Levels of advanced oxidation protein product (AOPP), TBARS, and FRAP of dogs with lymphoma (before and after chemotherapy) when compared to healthy dogs (control). Results were considered significant between groups when P < 0.05.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers

et al. 2015

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“…Regarding the hematological alterations, normocytic normochromic anemia is the most common alteration found in dogs with lymphoma, followed by leukocytosis, leukopenia, thrombocytopenia, neutrophilia and leukoerythroblastic reactions. Hematological alterations of patients with cancer may occur from the direct action of the tumor or paraneoplastic syndromes [4].…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous lymphoma is considered a rare form of lymphoma in dogs, representing only 1% of cutaneous neoplasms [4]. It may involve the oral mucosa and other organs, such as lymph nodes, spleen, liver and bone marrow [6].…”

Section: Introductionmentioning

confidence: 99%

Non-Epitheliotropic Cutaneous Lymphoma with Systemic Dissemination in a Dog

Rosseto

Pitol

Andreussi

et al. 2021

Acta Scientiae. Vet.

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Background: Cutaneous lymphoma is a highly malignant neoplasm, which can originate in the epidermis or dermis, as well as be disseminated to other organs such as lung, heart, arm, liver and bone marrow. It comes in the form of nodes of various sizes, erythematous and alopecic, itching may or may not occur. The diagnosis is made by cytological and histopathological examination of the compromised tissue. However, it is important to perform complementary tests for clinical staging and prognostic characterization. The objective is to report a case of non-epitheliotropic cutaneous lymphoma with systemic dissemination in a dog.Case: A female mixed bred adult canine was attended at the Veterinary Hospital of the Federal University of Mato Grosso do Sul with a history of progressive weight loss and the presence of alopecic and non-pruritic subcutaneous nodules in the torso, nasal plane and pelvic limbs, starting 4 months ago. After approximately 20 days, the presence of rapidly evolving ulcerated nodules was noted. On physical examination, generalized lymphadenomegaly was observed and among the dermatological findings were multiple nodules of varying sizes with the presence of ulceration in the center of the lesions, alopecia, erythema and raised edges, in the region of the nasal sinus, pelvic and thoracic limbs, tail, thoracolumbar and abdominal region. The animal also presented right pelvic limb edema with painful sensibility to manipulation CBC and biochemical tests (albumin, alanine aminotransferase, creatinine, urea, alkaline phosphatase, globulins, total proteins and fractions) were performed, being observed as normocytic normochromic type anemia alteration (erythrocytes: 2.78 106/µL; hemoglobin: 6.8 g/µL; globular volume: 18.8%), leukopenia (4,000/mm³) with presence of metamyelocytes (120/mm³) and rods (1,080/mm³) and lymphopenia (80/mm³). Three samples of the nodules were collected for histopathological examination and a definitive diagnosis of cutaneous lymphoma was obtained. The material was then submitted to immunohistochemical examination, which showed that it was a non-epitheliotropic cutaneous lymphoma of T immunophenotype. Due to the compromised quality of life and unfavorable prognosis, the owner opted for euthanasia of the animal. In the necropsy examination, lymph nodes, subcutaneous tissue, skeletal muscle, heart, pericardial sac, tongue and multifocal infiltrate of neoplastic cells were observed, findings suggestive of multicentric lymphoma or infiltrations by dissemination of cutaneous lymphoma.Discussion: Non-epitheliotropic skin lymphomas exhibit rapid progression and infiltration into lymph nodes and subsequent systemic involvement. The diagnosis is based on clinical-dermatological signs, fine needle cytology, histopathological and immunohistochemical examination. Normocytic normochromic anemia is the most observed alteration in patients with lymphoma, followed by leukocytosis, leukopenia, thrombocytopenia, neutrophilia and leukoerythroblastic reactions. Dogs with T-cell lymphoma have a worse prognosis for life span and disease-free intervals than those with B-cell lymphoma, so immunophenotyping is critical to determine prognosis. In the present report, histopathological and immunohistochemical examinations were decisive for the diagnosis of the present report, because the expression CD3 and the negativity for CD79a proved that the neoplasm is of T lymphocyte lineage. The definitive diagnosis was obtained by histopathology, however, immunohistochemistry determined the immunophenotype of the neoplasia as non-epitheliotropic T lymphocyte.

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“…O linfoma é uma neoplasia originária de tecidos linfoides, caracterizado pela proliferação de células linfoides malignas, podendo se desenvolver em qualquer órgão, o que difere das leucemias que tem origem na medula óssea (VALERIANO et al, 2017;FERREIRA;AZEVEDO;LEITE, 2015). O linfoma é considerado a neoplasia mais comumente tratada em cães, o que contribui por ser uma doença de alta incidência na população mundial canina (CÁPUA et al, 2011). Considerando o acometimento apenas em cães idosos, a sua prevalência pode chegar a 84 por 100.000 cães, e naqueles com menos de um ano de idade, a prevalência cai para 1,5 por 100.000 cães (VAIL; MACEWEN;YOUNG, 2001 A causa do linfoma ainda não está bem estabelecida, mas alguns fatores podem contribuir para o desenvolvimento da doença, como o aumento da sua ocorrência em cães com doenças autoimunes, por exemplo, a trombocitopenia imunomediada, que afeta cães independente do sexo e idade, têm sido associada a um maior risco de desenvolvimento do linfoma quando comparada com a população saudável.…”

Section: Discussionunclassified

Linfoma multicêntrico canino: uma sinopse sobre os aspectos clinicopatológicos e alterações laboratoriais

Beraldo¹,

Varzim²,

Pulz³

2020

Rev. Educ. Cont. Med. Vet. Zootec.

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O linfoma é uma neoplasia caracterizada pela proliferação de células linfoides malignas, que pode se desenvolver em qualquer órgão, acometendo inicialmente linfonodos, baço e fígado. Sua causa não é bem elucidada, porém acredita-se na etiologia multifatorial, fatores genéticos, deficiência imunológica e carcinógenos químicos. Existem quatro classificações anatômicas para o linfoma: multicêntrico, alimentar ou digestiva, mediastínico e extranodal, sendo que 80% dos casos em cães são classificados como linfomas multicêntricos. O diagnóstico é baseado em análises citológicas, histológicas e biologia molecular, que auxiliam no estabelecimento do prognóstico do animal considerando o grau de malignidade do linfoma e o tipo celular de origem. Os exames laboratoriais, como os perfis hematológicos e bioquímicos, fornecem dados para o acompanhamento do animal, acometimento e estadiamento da doença. Perante o exposto, constata-se que o linfoma é uma afecção de grande relevância dentre aquelas que acometem cães, portanto, este estudo tem o objetivo de aliar a base teórica frente à apresentação clínica do linfoma, fornecendo o conhecimento das principais alterações descritas para gerar um diagnóstico precoce, estabelecendo uma ponte de sucesso com o clínico e permitindo ao paciente melhor qualidade de vida e sobrevida perante a doença.

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Linfoma canino: clínica, hematologia e tratamento com o protocolo de Madison-Wisconsin

Abstract: Lymphoma is a neoplasm of high incidence in

Cited by 10 publications

References 11 publications

Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers

Oxidative stress in dogs with multicentric lymphoma: Effect of chemotherapy on oxidative and antioxidant biomarkers

Non-Epitheliotropic Cutaneous Lymphoma with Systemic Dissemination in a Dog

Linfoma multicêntrico canino: uma sinopse sobre os aspectos clinicopatológicos e alterações laboratoriais

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