Linezolid and quinupristin/dalfopristin resistance in vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus prior to clinical use in Turkey

Baysallar, Mehmet; Kılıç, Abdullah; Aydoğan, Hakan; Çilli, Feriha; Doğancı, Levent

doi:10.1016/j.ijantimicag.2003.09.029

Cited by 30 publications

(22 citation statements)

References 7 publications

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“…The increase in infections caused by these multi-drug-resistant organisms over the past decade poses problems due to the lack of available antimicrobial therapy 9 . Since the anaerobic microflora associated with aggressive oral cavity infections may be resistant to several antibiotics, there is an urgent need for antimicrobial agents which active against these resistant bacteria…”

Section: Discussionmentioning

confidence: 99%

Oral Kavite Enfeksiyonlarına Neden Olan Anaerobik Bakterilere Karşı Türk Propolis Örneklerinin In vitro Antimikrobiyal Aktivitesi

Özen¹,

Kılıç²,

Bedir³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryThe aim of this study was to evaluate the antimicrobial activity of propolis samples collected from different regions of Turkey against anaerobic bacteria causing especially oral cavity infections. A total of eleven anaerobic bacterial strains have been tested in this study. The strains were tested by agar dilution method for detecting minimum inhibitory concentration (MIC) and by macro dilution broth method for detecting minimum bactericidal concentration (MBC). Turkish propolis samples were found highly effective against all tested anaerobic bacteria compared with ethanol control, without statistical differences. The MIC and MBC of propolis samples ranged from 0.4 0.6 mg/ml to 108.1-186.2 mg/ml, respectively. Actinomyces odontolyticus was the most susceptible strains; whereas Prevotella intermedia was was the least susceptible strain to all tested propolis samples. Ilic/Erzincan (ER-I) propolis sample was the more effective against all tested anaerobic bacteria; whereas Bartin (BA) propolis sample was the less effective. Gram-positive anaerobic bacteria were detected to be the most sensitive to propolis samples; with the MIC values ranging from 0.4 to 6.1 mg/ml compared with Gram-negative anaerobic bacteria with MIC ranging from 5.8 to 108.1 mg/ml (P<0.05). As a result of, Turkish propolis samples had antibacterial activity against anaerobic bacteria especially causing oral cavity infections. Because of the high rate of resistance of the anaerobic bacteria isolated from oral cavity infections, standardized preparations of propolis are suggested to use in treatment of this kind of infections. However, further studies are needed to be performed on the clinical applications of propolis in oral cavity infections.

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Section: Discussionmentioning

confidence: 99%

Oral Kavite Enfeksiyonlarına Neden Olan Anaerobik Bakterilere Karşı Türk Propolis Örneklerinin In vitro Antimikrobiyal Aktivitesi

Özen¹,

Kılıç²,

Bedir³

et al. 2009

Kafkas Univ Vet Fak Derg

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“…(19) , 63 MRSA suşunda, Baysallar ve ark. (20) , 38 MRSA suşunda, Yula ve ark. (21) , üç MRSA ve 21 MSSA suşunda K/D'e karşı herhangi bir direnç saptamamışken, Tünger ve ark.…”

Section: çAlışmaya Dâhil Edilen 151 S Aureus Izolatınınunclassified

Determination of Macrolide, Lincosamide and Streptogramin B Resistance in Staphylococcus aureus Strains by Phenotypical Methods and Investigation of In Vitro Activity of Quinupristin/Dalfopristin

Çiçek¹,

Tuncer²,

Sancak³

et al. 2017

TMCD

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“…Ül ke miz de MİK de ğer le ri nin araş tı rıl -dı ğı ça lış ma lar da li ne zo li de du yar lı lı ğı azal mış veya di renç li sta fi lo kok izo la tı bil di ril me miş tir. 15,17,18,20 An cak, baş ka ül ke ler den di renç li izo lat lar en der de ol sa ra por edil miş tir. 7 Çok mer kez li bir sür ve yans ça lış ma sın da, ço ğun lu ğu nu ABD 'nin oluş tur du ğu, ay rı ca Av ru pa, La tin Ame ri ka ve As ya Pa si fik Böl-ge sin den top la nan 74 S. au re us ve KNS izo la tın da li ne zo li de du yar lı lık ta azal ma (MİK: >4 mg/L) saptan mış tır.…”

Section: 11unclassified

“…Tür ki ye' de ya pı lan ço ğu ça lış ma da li ne zo lid di ren ci sap tan ma mış -tır. 20,27,28,30 An cak Ulu soy ve ark. E. fa e ci um (n:15) izo lat la rın da %6,7 ora nın da li ne zo lid di ren ci bil dirmiş ler dir.…”

Section: 11unclassified

In Vitro Susceptibilities of Staphylococcus and Enterococcus Isolates to Linezolid, Daptomycin, Teicoplanin and Fusidic Acid

Ertem¹,

Öztürk²,

Hatipoğlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Koagülaz negatif stafilokoklar (KNS), Staphylococcus aureus (S. aureus) ve enterokoklarda glikopeptid direnci giderek artmaktadır. Bu çalışmanın amacı, hastane kaynaklı metisiline dirençli stafilokok ve enterokok izolatlarının son yıllarda kullanıma giren linezolid ve daptomisin ile uzun zamandır kullanılan teikoplanin ve fusidik asit (enterokoklar hariç) için in vitro duyarlılığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hastane kaynaklı toplam 172 izolat [metisiline dirençli S. aureus (MRSA, n: 60), metisiline dirençli koagülaz negatif stafilokok (MRKNS, n: 60) ve MİK 90 değerleri daptomisin için (0,125 ve 1 mg/L) bulunurken, E. faecium izolatlarında değerler daptomisin, linezolid ve teikoplanin için birbirine yakın çıkmıştır (1 ve 1,5-2 mg/L). Stafilokok ve enterokok izolatlarında daptomisin ve linezolid direnci bulunmamıştır. Fusidik aside karşı MRSA izolatlarında %8,3, MRKNS izolatlarında %31,7 oranında direnç bulunmuştur. Tüm MRSA izolatları teikoplanine duyarlıyken, 7 MRKNS ve 1 E.faecalis izolatı orta duyarlı, 3 MRKNS (%5) ve 2 E. faecium (%10,5) izolatı ise teikoplanine dirençli bulunmuştur. S So on nu uç ç: : Stafilokoklarda teikoplanin direncinin düşük olması, ek olarak hem stafilokoklarda hem de enterokoklarda linezolid ve daptomisine karşı direnç bulunmaması sevindiricidir. Öte yandan MRKNS izolatlarında fusidik aside karşı direnç dikkat çekici düzeydedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Stafilokok; metisiline dirençli Staphylococcus aureus; enterokokus; ilaç direnci, bakteriyel A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Glycopeptide resistance is increasing among Staphylococcus aureus (S. aureus), coagulase negative staphylococci (CoNS) and enterococcus strains. The aim of our study was to evaluate of in vitro susceptibilities of nosocomial staphylococcus and enterococcus isolates to recently used antibiotics (linezolid, daptomycin) and long-standing used antibiotics (teicoplanin and fusidic acid, except for enterococci). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study was performed with 172 clinical isolates [methicillin resistant S. aureus (MRSA, n:60) and (methicillin resistant coagulase negative staphylococcus (MRCoNS, n:60) and enterococci (33 E. faecalis, 19 E. faecium)]. Identification of the bacteria was done by conventional methods while VITEK II compact system (bioMérieux, France) was also used for enterococci. R Re es su ul lt ts s: : The minimum inhibitory concentrations (MICs) of all antimicrobial agents were tested by E-test (AB bioMérieux, Sweden). In MRSA isolates, the lowest MIC 50 and MIC 90 values were found to daptomycin (0.064 and 0.125 mg/L) and fusidic acid (0.032 and 0.47 mg/L). In MRCoNS isolates, the lowest MIC 50 and MIC 90 values were as 0.038 mg/L and 0.38 mg/L for daptomycin. In E. faecalis isolates, the lowest values were 0.125 and 1 mg/L for daptomycin while in E. faecium isolates the values were similar (1 and 1.5-2 mg/L) for daptomycin, linezolid and t...

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Linezolid and quinupristin/dalfopristin resistance in vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus prior to clinical use in Turkey

Cited by 30 publications

References 7 publications

Oral Kavite Enfeksiyonlarına Neden Olan Anaerobik Bakterilere Karşı Türk Propolis Örneklerinin In vitro Antimikrobiyal Aktivitesi

Oral Kavite Enfeksiyonlarına Neden Olan Anaerobik Bakterilere Karşı Türk Propolis Örneklerinin In vitro Antimikrobiyal Aktivitesi

Determination of Macrolide, Lincosamide and Streptogramin B Resistance in Staphylococcus aureus Strains by Phenotypical Methods and Investigation of In Vitro Activity of Quinupristin/Dalfopristin

In Vitro Susceptibilities of Staphylococcus and Enterococcus Isolates to Linezolid, Daptomycin, Teicoplanin and Fusidic Acid

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