Linear Psoriasis and ILVEN: Is Lumping or Splitting Appropriate?

Happle, Rudolf

doi:10.1159/000090647

Cited by 23 publications

(26 citation statements)

References 12 publications

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“…LPs may be associated with non segmental plaques of psoriasis vulgaris (superimposed linear psoriasis type) or it can occur as an isolated lesion epidermal psoriasi form hyperplasia, superficial pallor with diminished granular layer, incipient subcorneal spongiform pustule formation and staggered Linear psoriasis may be confused with inflammatory linear verrucous epidermal nevus (ILVEN) or Koebners's response of psoriasis over verrucous epidermal nevus. 5 Saraswat et al described the clinical differences between the two entities. ILVEN tends to develop during the first month of life, progresses slowly, can be very pruritic and is usually unresponsive to treatment.…”

Section: Discussionmentioning

confidence: 99%

“…This rare form of psoriasis was first described in 1951. There are few cases reported in the literature 1,2,3 and therefore there is no estimated prevalence. Also because of its clinical and histological similarity to Linear Verrucous Epidermal Nevus (ILVEN), some cases are probably not reported, contributing to the under diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Pathogenesis of linear Psoriasis is not clear but it could be explained by the concept of genetic mosaicism. 2 Happle proposed the pathogenesis of linear psoriasis as somatic recombination of a gene predisposing to psoriasis leading to segmental mosaicism. This hypothesis offers a reasonable explanation for linear psoriasis being a nonhereditary trait and the linear distribution similar to many other mosaic skins disorders.…”

Section: Introductionmentioning

confidence: 99%

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Linear psoriasis-a rare presentation

Rahaman

Islam²,

Ullah

et al. 2015

Northern Int. Med. Coll. J.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Linear psoriasis-a rare presentation

Rahaman

Islam²,

Ullah

et al. 2015

Northern Int. Med. Coll. J.

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“…Moreover, there are also some clinical differences. Bier's spots can progressively enlarge and start in different sites after a proper stimulus (venous hypertension), which is not the case with the constitutive speckled vascular mottling of the skin [2] . On the other hand, Bier's spots have also been linked to some pathological conditions, which is not the case for constitutive speckled vascular mottling of the skin.…”

mentioning

confidence: 99%

Inflammatory Verrucous Epidermal Naevus Presenting as a Psoriasiform Plaque

Simonart¹,

Heenen²

2007

Dermatology

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“…In contrast, linear psoriasis tends to be of late onset, is generally asymptomatic or only mildly pruritic and responds well to topical or systemic antipsoriatic treatment. 1 There may be an association between its distribution along Blaschko lines, human leukocyte antigen (HLA) class I alleles 2 and somatic recombination. 3 Systemic treatments for linear psoriasis are not recommended unless the skin lesions are particularly burdensome and cannot be controlled with topical agents or narrow-band ultraviolet B phototherapy.…”

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confidence: 99%

Linear psoriasis: Figure 1:

Li¹,

Man²

2012

CMAJ

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A 69-year-old man presented with a 40-year history of recurrent asymptomatic rashes on the left side of his body. Examination showed linear scaly plaques on his left arm ( Figure 1A), the left side of his chest and abdomen, the left flank ( Figure 1B) and the left leg, distributed along Blaschko lines (invisible lines on the skin that may represent fetal epidermal cell migration). Auspitz sign (the appearance of multiple fine bleeding points after gently scraping the scaly plaques) was positive. Histopathologic findings from a skin biopsy taken from the left forearm were diagnostic of psoriasis (Appendix 1, available at www .cmaj.ca /lookup /suppl /doi :10.1503 /cmaj .110866 /-/DC1). On the basis of these clinical and histopathologic signs, we confirmed the diagnosis of linear psoriasis. Following treatment with topical calcipotriol-betamethasone diproprionate ointment for six weeks, the pa tient's skin condition nearly cleared up; however, the lesions returned four weeks after treatment was stopped.Psoriasis is a common, chronic, inflammatory and proliferative skin disorder, affecting about 2% of the population. Linear psoriasis is an unusual subtype characterized by a distribution of the psoriatic lesions along Blaschko lines. The main differential diagnosis is inflammatory linear verrucous epidermal nevus, which also follows Blaschko lines but usually begins in infancy. This condition is intensely pruritic and usually resistant to antipsoriatic therapies. In contrast, linear psoriasis tends to be of late onset, is generally asymptomatic or only mildly pruritic and responds well to topical or systemic antipsoriatic treatment.1 There may be an association between its distribution along Blaschko lines, human leukocyte antigen (HLA) class I alleles 2 and somatic recombination.

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Linear Psoriasis and ILVEN: Is Lumping or Splitting Appropriate?

Cited by 23 publications

References 12 publications

Linear psoriasis-a rare presentation

Linear psoriasis-a rare presentation

Inflammatory Verrucous Epidermal Naevus Presenting as a Psoriasiform Plaque

Linear psoriasis: Figure 1:

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