Linear leucoderma following intralesional steroid: A report of three cases

Dhawan, Amit; Bisherwal, Kavita; Grover, Chander; Tanveer, Nadeem

doi:10.4103/0974-2077.158453

Cited by 13 publications

(9 citation statements)

References 3 publications

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“…It is believed that the presence of insoluble corticosteroid crystals within these lymphatic vessels causes localized lipolysis and skin depigmentation along the periliphatic skin. Linear periliphatic subcutaneous atrophy and depigmentation can occur as a result of single or multiple injections with a latency period ranging from 2 weeks to several months after the initial injection 11 . Although linear subcutaneous atrophy and skin hypopigmentation may persist for a year or more, spontaneous resolution or resolution due, as in our case, to the injection of a hyaluronic acid filler has also been found.…”

Section: Discussionsupporting

confidence: 50%

A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report

Piccolo

Pensa

Zangrilli

et al. 2020

Dermatologic Therapy

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Intralesional steroid injection is a treatment method frequently used to resolve a large number of orthopedic, rheumatological, dermatological, and neurological disorders. Although this treatment is very effective, it is not without possible side effects, both systemic and local, among which we can mention pain, bleeding, ulceration, atrophy, pigmentary changes, calcification, secondary infections, formation of granulomas, allergic reactions and, in very rare cases, the development of linear atrophy, and hypopigmentation. Here, we present a case of frontal linear skin atrophy after intralesional steroid injection for the treatment of alopecia areata (AA) in a 29 yearold patient, successfully treated with a hyaluronic acid filler.

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Section: Discussionsupporting

confidence: 50%

A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report

Piccolo

Pensa

Zangrilli

et al. 2020

Dermatologic Therapy

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“…17,21,22 According to other case reports, hypopigmentation may develop 1-4 months later, following single or multiple injections. 23,24 This is similar to our experience. Our patient developed skin hypopigmentation and subcutaneous fat atrophy 3 months after a single injection with triamcinolone acetonide and resolved spontaneously within one and a half years.…”

Section: Discussionsupporting

confidence: 90%

“…Dhawan et al reported such dermal adverse effect after intralesional injection in two patients for ganglion over the wrist and a patient for lichen planus on the foot. 24 Salvatierra et al described such a lesion after triamcinolone injection for a tennis elbow. 19 Another researcher reported an atrophic and hypopigmented lesion in the postauricular region following multiple intralesional triamcinolone acetonide for the treatment of a keloid on the left ear.…”

Section: Discussionmentioning

confidence: 99%

Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report

Prihatsari¹,

Hidayati²,

Damayanti³

et al. 2021

Anaesth. pain intensive care

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Corticosteroid injections have been shown to be an effective treatment modality in many of the musculoskeletal and rheumatologic conditions. Yet, the potential adverse effects of corticosteroid injections have not been given much attention. One of the potential adverse effects that should be considered by clinicians is skin hypopigmentation and subcutaneous fat atrophy. Although it is a rare side effect, it may have cosmetically unpleasant effect. The aim of this case report is to highlight the importance of providing adequate information to the patients regarding these dermal adverse effects of corticosteroid injections. We report the case of a 31-year-old female who suffered from skin hypopigmentation and subcutaneous fat atrophy after triamcinolone injection given for de Quervain’s tenosynovitis. Key words: de Quervain’s tenosynovitis; Fat atrophy; Hypopigmentation; Corticosteroid injections; Adverse effects; Pain Citation: Prihatsari F, Hidayati HB, Damayanti D, Budisulistyo T. Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report. Anaesth. pain intensive care 2021;25(6):807–811; DOI: 10.35975/apic.v25i6.1708

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“…35 In addition, TAC has a large size, higher tendency to aggregate and higher density. 36 It was noticed that these precipitations disappeared gradually in one of these patients within the period of follow-up.…”

Section: Discussionmentioning

confidence: 83%

Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

Neinaa

Elsayed²,

Mohamed

et al. 2021

Dermatologic Therapy

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Keloids characterize a definitely challenging type of cutaneous scars for which a diversity of therapeutic modalities has been suggested. The aim of this work was to compare the therapeutic efficacy of intralesional injection of botulinum toxin type‐A (BTX‐A), platelet rich plasma (PRP), and triamcinolone acetonide (TAC) in keloids. A total of 60 keloids patients were enrolled and divided randomly into three equal groups. Group I treated by intralesional BTX‐A injection, group II treated by intralesional PRP injection, and group III treated by intralesional TAC injection. Clinical assessment was done by Vancouver Scar Scale (VSS), Verbal Rating Scale (VRS), and dermoscopic examination. Additionally, histopathology and immunohistochemistry of connective tissue growth factor (CTGF) expression were evaluated. The results of this study revealed significant improvement of both VSS and VRS in response to all treatment modalities. There was significant improvement of VSS in BTX‐A and PRP groups more than TAC group. However, no significant difference observed between BTX‐A and PRP groups. Immunohistochemical examination showed significant decrease of CTGF expression after treatment in BTX‐A and PRP groups more than TAC group. In conclusion, both BTX‐A and PRP could yield a chance for cosmetically better outcomes in keloids treatment than conventional TAC injection.

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Linear leucoderma following intralesional steroid: A report of three cases

Cited by 13 publications

References 3 publications

A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report

A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report

Hypopigmentation and subcutaneous fat atrophy associated with corticosteroid injection: a case report

Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

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