Linear IgA disease: the IgA and IgG response to the epidermal antigens demonstrates that intermolecular epitope spreading is associated with IgA rather than IgG antibodies, and is more common in adults

Abstract

There was variation in the autoantibody response within the disease and the patient, with regard to target molecules and autoantibody class. The finding that IgG as well as IgA autoantibodies predominantly target BP180 supports a pivotal role for collagen XVII in adult and childhood LAD. The IgG response was very restricted compared with IgA autoantibodies (P < 0.01). Autoantibodies from children had a more restricted antigen repertoire than from adults (P < 0.05). Epitope spreading is common in LAD and is affected by the class of autoantibody and age of the patient.

Drug-Induced Linear IgA Bullous Dermatosis

“…The target antigens have been investigated extensively in idiopathic LABD (50, 51). Although they are heterogenous, LAD285, BP180, and BP230 have been identified as major target antigens in LABD.…”

“…Although they are heterogenous, LAD285, BP180, and BP230 have been identified as major target antigens in LABD. Particularly, BP180, the NC16A domain, or the soluble 120kDA/97kDa ectodomain has been considered to contain the major targets of IgG and IgA antibodies in BP, LABD, and other immunobullous diseases (50). Although there are only a few reports on target antigens in drug‐induced LABD (30–32), the same antigens as idiopathic LABD have been identified (Table 2).…”

Subacute prurigo‐like linear IgA disease

“…Surprisingly, linear BMZ deposits of IgA and C3 were detected by DIF, and a diagnosis of LAD was made. SSS‐DIF, SSS‐IIF, and IB analyses showed that IgA autoantibodies were directed towards an epidermal antigen of 230 kDa, which is often targeted in LAD 3 . The responsiveness to dapsone, although incomplete because of the need to stop this drug, represented another typical feature of the disease 4 …”

A Determination of the Range of Oral Conditions Submitted for Microscopic and Direct Immunofluorescence Analysis

“…The final diagnosis of linear IgA disease was dependent upon a linear BMZ deposition of only IgA on DIF 6,10 …”