Subacute prurigo‐like linear IgA disease

Torchia, Daniele; Caproni, Marzia; Cozzani, Emanuele; Ketabchi, Sheyda; Fabbri, Paolo

doi:10.1111/j.1365-4632.2007.03314.x

Cited by 10 publications

(5 citation statements)

References 8 publications

(8 reference statements)

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“…LABD is a rare subepidermal blistering disease characterized by linear IgA deposits at the BMZ. LABD usually presents with vesicles, blisters, and/or erosions involving the skin and – frequently – the mucous membranes, 1 while papules or nodules are generally absent with the exception of two cases recently described by our research group 2,3 . In the case herein reported, the patient presented with typical symptoms and signs of subacute prurigo, a prurigo variant characterized by severely pruritic and excoriated papules that are smaller and less elevated than those of prurigo nodularis 4,5 …”

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confidence: 67%

A further case of subacute prurigo‐like linear IgA bullous dermatosis: growing evidence of a new subset

et al. 2012

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A 28-year-old woman was referred to our clinic with a one-year history of recurrent eruptions of severely itchy disseminated papular lesions. A short course of oral steroids only produced temporary remission of the lesions.Physical examination showed numerous roundish papules, some of them studded by erosions or serosanguineous crusts, distributed on the face, scalp, neck, abdomen, and limbs ( Fig. 1a,b). Erosive and hyperkeratotic lesions were present on the cheek mucosa, bilaterally ( Fig. 1c).Laboratory tests were normal, while the histopathological examination of a papular lesion showed a subepidermal blister with fibrin deposits and numerous neutrophils ( Fig. 1d). A mixed inflammatory infiltrate was localized in the perivascular sites of superficial and medium dermis (Fig. 1d). Direct immunofluorescence (DIF) of the perilesional skin demonstrated linear deposits of immunoglobulin A (IgA) along the basement membrane zone (BMZ) (Fig. 1e). Indirect immunofluorescence (IIF), using monkey esophagus and human healthy skin as substrates, was negative. Salt-split skin (SSS)-IIF showed a linear deposit of IgA along the epidermal side of normal human skin. Immunoblot analysis of both epidermal and dermal extracts was negative.Based on these findings, we diagnosed linear IgA bullous dermatosis (LABD), and oral therapy with prednisone 50 mg daily was started, with good response in two months. Therefore, prednisone was slowly tapered by 5 mg every two weeks, with long-term remission. After eight months of follow-up, the patient did not show any relapse of the disease.LABD is a rare subepidermal blistering disease characterized by linear IgA deposits at the BMZ. LABD usually presents with vesicles, blisters, and/or erosions involving the skin and -frequently -the mucous membranes, 1 while papules or nodules are generally absent with the exception of two cases recently described by our research group. 2,3 In the case herein reported, the patient presented with typical symptoms and signs of subacute prurigo, a prurigo variant characterized by severely pruritic

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confidence: 67%

A further case of subacute prurigo‐like linear IgA bullous dermatosis: growing evidence of a new subset

et al. 2012

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“…Indeed, serum IgA autoantibodies from patients with LABD recruited and activated human granulocytes, mostly neutrophils, at the dermo-epidermal junction in cryosections of human skin (8). There is a report of an atypical case of LABD with IgA anti-BP230 antibodies, who showed non-bullous, subacute prurigo-like eruptions with neutrophilic microabscesses without dermo-epidermal separation (9). Finally, our patient had IgE antibodies against BP180 NC16a domain and BP230.…”

Section: Pemphigoid Nodularis With Diverse Igg Iga and Ige Antibodiementioning

confidence: 84%

Pemphigoid Nodularis with Diverse IgG, IgA and IgE Antibodies Showing Neutrophilic Papillary Microabscesses

Asahina¹,

Niizuma²,

Ohzono³

et al. 2015

Acta Derm Venerol

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“…There are some reports of prurigo simplex associated with bullous diseases: a case of “subacute prurigo-like linear IgA disease” and 2 cases of bullous pemphigoid mimicking prurigo simplex ( 17 – 19 ). In all cases, direct immunofluorescence was positive.…”

Section: Resultsmentioning

confidence: 99%

Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series

Wallengren¹

2021

Acta Derm Venereol

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Prurigo simplex or “itchy red bump” disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: “prurigo simplex”, “prurigo simplex subacuta”, “subacute prurigo”, “chronic papular dermatitis in adults” and “itchy red bump disease”. Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) matched the description in literature. Small, severely itchy papules without secondary skin lesions continued to appear for years (mean 5.6 years). Skin biopsies revealed lymphocytic perivascular infiltrates, few eosinophils and occasionally spongiosis. Treatment with long-term methotrexate or cyclosporine cleared the symptoms. Some major and minor diagnostic criteria for prurigo simplex are proposed and compared with chronic prurigo.

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Subacute prurigo‐like linear IgA disease

Cited by 10 publications

References 8 publications

A further case of subacute prurigo‐like linear IgA bullous dermatosis: growing evidence of a new subset

A further case of subacute prurigo‐like linear IgA bullous dermatosis: growing evidence of a new subset

Pemphigoid Nodularis with Diverse IgG, IgA and IgE Antibodies Showing Neutrophilic Papillary Microabscesses

Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series

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