Linear drug release membrane prepared by a modified coaxial electrospinning process

Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems

“…46 Solvents, solutions of small molecules, or unspinnable diluted polymer solutions can be used as outer fluids to yield a series of modified triaxial electrospun products, similar to those which have been generated using modified coaxial electrospinning. [47][48][49] (4) Implementation of other types of multiple-fluid electrospinning for creating complicated functional nanostructures. Many other types of complicated nanostructures, such as side-by-side or combinations of side-by-side and core-sheath materials, may also be obtained (Figure 1).…”

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

“…In the traditional coaxial 134 process the sheath working fluid must be electrospinnable, but a modified process in 135 which one can utilize unspinnable liquids as the sheath fluid is also possible. The number of polymers which can be directly electrospun is rather limited, but there are 137 numerous unspinnable liquids, and the modified coaxial process should hence further 138 expand the range of functional nanofibers which can be produced [38,42,43].…”

“…However, it can 389 easily result in an anaphylactic reaction, and to an allergic reaction in the digestive 390 tract [52,53]. With traditional electrospun nanofibers, the drug is released by diffusion 391 through an insoluble polymeric matrix, or by an erosion mechanism from a 392 water-soluble carrier (or a combination of both processes) [39,43]. Here the drug 393 release from the core-shell composites is expected to include two successive steps 394 (Fig.…”

The Influence of Sheath Solvent’s Flow Rate on the Quality of Electrospun Ethyl Cellulose Nanofibers

“…However, high concentration polymer solutions often result in clogging of the spinneret and failure of the electrospinning process. Thus polymers often have narrow windows of electrospinnable solution concentrations, and the objective of obtaining finer structures (such as by lowering polymer concentration, by adding salt or surfactant, and by manipulating the electrospinning parameters) is often limited and compromised by sacrificing the fiber uniformity [6,7].…”