Linear atrophoderma of Moulin: postulation of mosaicism for a predisposing gene

Danarti, Retno; Bittar, Mario; Happle, Rudolf; König, Arne

doi:10.1067/s0190-9622(03)00895-8

Cited by 59 publications

(53 citation statements)

References 32 publications

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“…APP can be differentiated from LAM by its bilateral, symmetric pattern not following Blaschko's lines, and older lesions having central induration. 2 Plaque type morphea, in contrast to LAM, occurs predominantly in females, and lesions are ivory or white with a lilac margin, and densely sclerotic. 2 Linear scleroderma is distinguished from LAM by the presence of dermal sclerosis.…”

Section: 4mentioning

confidence: 99%

“…2 Plaque type morphea, in contrast to LAM, occurs predominantly in females, and lesions are ivory or white with a lilac margin, and densely sclerotic. 2 Linear scleroderma is distinguished from LAM by the presence of dermal sclerosis. 1 In conclusion, we report the first case of LAM associated with mild pruritus at the onset of each new lesion and progressing slowly over 46 years.…”

Section: 4mentioning

confidence: 99%

“…3 The trunk and limbs are primarily affected, with no history of preceding induration, inflammation, or scleroderma. 2 Lesions typically develop over a limited time period and then remain present. 2 New lesions may arise.…”

Section: 2mentioning

confidence: 99%

“…2 Lesions typically develop over a limited time period and then remain present. 2 New lesions may arise. The prognosis is favorable, with no systemic manifestations or damage to underlying structures reported.…”

Section: 2mentioning

confidence: 99%

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Linear atrophoderma of Moulin progressing slowly over 46 years

Afshar

Melancon²,

Hata³

2012

J Dermatol Case Rep

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A 66-year-old man presented with a 46-year history of evolving tan soft atrophic confluent plaques in a strikingly Blaschkoid distribution, involving the left upper back, shoulder, upper arm, chest and flank (Fig. 1). Initial onset, at age 20, consisted of a single mildly pruritic pink patch on the left back that was unresponsive to topical antifungals. Each new lesion arose similarly as a pink pruritic patch, subsequently becoming depressed, hyperpigmented, and asymptomatic over several years. Lesions were never scaly, firm, or indurated. Punch biopsy specimens were DOI: http://dx.doi.org/10.3315/jdcr.2012.1121 125 PHOTOLETTER TO THE EDITOR AbstractLinear atrophoderma of Moulin is a rare acquired disorder arising most commonly during childhood or adolescence, occurring equally in both sexes and characterized by hyperpigmented atrophoderma in a unilateral bandlike distribution along the lines of Blaschko. Since Moulin et al described the condition in 1992, only a few dozen cases have been reported. It has been postulated that linear atrophoderma of Moulin may be due to mosaicism. A 66-year-old man presented with a 46-year history of evolving tan soft atrophic confluent plaques in a strikingly Blaschkoid distribution, involving the left upper back, shoulder, upper arm, chest and flank. Initial onset, at age 20, consisted of a single mildly pruritic pink patch on the left back that was unresponsive to topical antifungals. Each new lesion arose similarly as a pink pruritic patch, subsequently becoming depressed, hyperpigmented, and asymptomatic over several years. Lesions were never scaly, firm, or indurated. Punch biopsy specimens were obtained. The clinical and histopathological features confirmed the diagnosis of linear atrophoderma of moulin. Our present case has the characteristic clinical and histopathological features of linear atrophoderma of Moulin, but is the first reported case with mild pruritus at the onset of each new lesion and progressing slowly over 46 years. The lack of any systemic symptoms or other complications in our patient reaffirms the benign nature of this skin disease. (J Dermatol Case Rep. 2012; 6(4): 125-126) Key words: atrophy, plaque, pruritus

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Section: 4mentioning

confidence: 99%

Section: 4mentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

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Linear atrophoderma of Moulin progressing slowly over 46 years

Afshar

Melancon²,

Hata³

2012

J Dermatol Case Rep

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“…After the 5 first cases of linear atrophoderma reported by Moulin et al [1], 26 additional cases were described ([2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23], summarized in table 1). We include in our review of the literature a case of unilateral idiopathic atrophoderma described as a Pasini and Pierini entity but with lesions arranged along Blaschko's lines [24].…”

Section: Methodsmentioning

confidence: 99%

Linear Atrophoderma of Moulin: Report of 4 Cases and 20th Anniversary Case Review

Villani

Amini‐Adlé²,

Wagschal³

et al. 2013

Dermatology

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Background: Linear atrophoderma of Moulin (LAM) is a rare clinical entity which was first described by Moulin et al. in 1992. The diagnosis is clinical, characterized by acquired unilateral hyperpigmented, depressed band-like skin lesions following Blaschko's lines. The disease typically affects children or adolescents and has a good prognosis without evidence of long-term progression. To date, the pathophysiology is unclear. Different authors hypothesize that the disease is secondary to a mosaic manifestation as a result of a post-zygotic mutational event. Observations: Four patients (2 men, 2 women) had a history of unilateral band-like skin lesions located on the lower legs (50%) or the trunk (50%). Physical examination showed atrophic and hyperpigmented skin lesions along Blaschko's lines, which appeared during childhood in 3 cases and at the age of 20 in the last case. Lesions had progressed rapidly but seemed to have stabilized so far except for 1 case who presented spontaneous improvement. Histopathological examination revealed a normal epidermis with a hyperpigmented basal layer and a perivascular lymphocytic infiltrate in the dermis. Conclusion: LAM is a rare disease with 32 reported cases and remains an exclusion diagnosis. Since the problem is mainly esthetic, treatments should not be too aggressive.

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Disorders of Connective Tissue

Burrows¹,

Lovell²

2004

Rook's Textbook of Dermatology

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Linear atrophoderma of Moulin: postulation of mosaicism for a predisposing gene

Cited by 59 publications

References 32 publications

Linear atrophoderma of Moulin progressing slowly over 46 years

Linear atrophoderma of Moulin progressing slowly over 46 years

Linear Atrophoderma of Moulin: Report of 4 Cases and 20th Anniversary Case Review

Disorders of Connective Tissue

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