Linear Atrophoderma of Moulin:A Case Report and Review of the Literature

Abstract

Linear atrophoderma of Moulin (LAM) is a rare dermatosis in childhood and early adolescence. The exact etiology of LAM is still obscure. Several treatment modalities were reported but none was consistently successful. We report a case of LAM in which a favorable outcome was obtained with topical calcipotriol. The relevant literature is also reviewed.

Linear atrophoderma of Moulin

“…A partial response to topical calcipotriol was reported. 7 A case of LAM successfully treated with methotrexate 20 mg/wk for 6 months with an improvement of pigmentation and atrophy was reported. 8 The authors suggested that LAM, atrophoderma of Pasini and Pierini, and linear scleroderma may be a spectrum of a common disease entity in view of the response to methotrexate, which is an effective therapeutic option for morphea.…”

Linear atrophoderma of moulin over face: An exceedingly rare entity

“…[1] Postzygotic mutation in lamin A gene has been postulated as a possibility for developing this disorder. [2] The trunk and limbs are usually involved without any preceding inflammation or subsequent induration and sclerosis.…”

“…[4] However, subcutaneous tissue is not routinely mentioned to be reduced according to other reports and text. [12] LAM is a self-limited disease. Progression of the lesions usually stops within a few months without any pattern of remission.…”

“…Progression of the lesions usually stops within a few months without any pattern of remission. [1] Hematoxylin and eosin staining usually show normal or atrophic epidermis, along with hyperpigmentation of the basal layer. The collagen bundles in the mid and deep dermis may be edematous or slightly homogenized in appearance.…”

“…[4] The partial improvement was reported with topical calcipotriol, intravenous penicillin together with topical PUVA, oral Potaba (potassium para-aminobenzoate), high-dose Vitamin E (400 IU/day), and topical clobetasol propionate. [1] Since none of these medications are uniformly effective for this rare dermatosis, especially over face, we started topical tretinoin (0.05%) cream empirically once at night. If we do not see any appreciable improvement after 3 months, we would consider starting methotrexate.…”