Linear and Non-linear Correlations Between Serum Phosphate Level and Bone Mineral Density in Type 2 Diabetes

Yang, Yibing; Liu, Guangwang; Zhang, Yao; Xu, Guo; Yi, Xilu; Liang, Jing; Zhao, Chengcheng; Liang, Jun; Ma, Chao; Ye, Yangli; Yu, Mi; Qu, Xinhua

doi:10.3389/fendo.2020.00497

Cited by 3 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a significant positive correlation between serum phosphorus and TH BMD. Previous studies have shown that relatively high blood phosphorus levels in the normal range may be beneficial to BMD (37). Phosphate is important for osteoblast differentiation and extracellular matrix mineralization, with its level directly affecting bone metabolism (38).…”

Section: Discussionmentioning

confidence: 99%

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

et al. 2022

View full text Add to dashboard Cite

BackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodThis cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.ResultsPearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).ConclusionIn older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

et al. 2022

View full text Add to dashboard Cite

show abstract

A non-linear positive relationship between serum phosphate and clinical outcomes in sepsis

Guo¹,

Su²,

He³

et al. 2022

Heliyon

View full text Add to dashboard Cite

Association between BMD and coronary artery calcification: an observational and Mendelian randomization study

Lu,

Lary,

Hodonsky

et al. 2024

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Observational studies have reported inconsistent associations between bone mineral density (BMD) and coronary artery calcification (CAC). We examined the observational association of BMD with CAC in two large population-based studies and evaluated the evidence for a potential causal relation between BMD and CAC using polygenic risk scores (PRS), 1- and 2-sample Mendelian randomization (MR) approaches. Our study populations comprised 1414 individuals (mean age 69.9 years, 52.0% women) from the Rotterdam Study and 2233 individuals (mean age 56.5 years, 50.9% women) from the Framingham Heart Study with complete information on CAC and BMD measurements at the total body (TB-), lumbar spine (LS-), and femoral neck (FN-). We used linear regression models to evaluate the observational association between BMD and CAC. Subsequently, we compared the mean CAC across PRSBMD quintile groups at different skeletal sites. In addition, we used the 2-stage least squares regression (2SLS) and the inverse variance weighted (IVW) model as primary methods for 1- and 2-sample MR to test evidence for a potentially causal association. We did not observe robust associations between measured BMD levels and CAC. These results were consistent with a uniform random distribution of mean CAC across PRSBMD quintile groups (p-value >0.05). Moreover, neither 1- nor 2-sample MR supported the possible causal association between BMD and CAC. Our results do not support the contention that lower BMD is (causally) associated with an increased CAC risk. These findings suggest that previously reported epidemiological associations of BMD with CAC are likely explained by unmeasured confounders or shared etiology, rather than by causal pathways underlying both osteoporosis and vascular calcification processes.

show abstract

Linear and Non-linear Correlations Between Serum Phosphate Level and Bone Mineral Density in Type 2 Diabetes

Cited by 3 publications

References 41 publications

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

A non-linear positive relationship between serum phosphate and clinical outcomes in sepsis

Association between BMD and coronary artery calcification: an observational and Mendelian randomization study

Contact Info

Product

Resources

About