Linear acral pseudolymphomatous angiokeratoma of children (APACHE): Further evidence that APACHE is a cutaneous pseudolymphoma

Kiyohara, Takahiro; Kumakiri, Masanobu; Kawasaki, Takeo; Takeuchi, Akiteru; Kuwahara, Hiroaki; Ueda, Takanori

doi:10.1067/mjd.2003.127

Cited by 24 publications

(39 citation statements)

References 6 publications

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“…In addition, in our thorough review of the literature we found a case published under the name of ‘linear APACHE’ in a 9-year-old Japanese girl presenting with a dark red, linear plaque on the posterior area of the right lower leg for about 5 years. In this case, the initial scattered papules had progressively coalesced into a linear plaque measuring 50 × 12 mm [4]. We also found a similar clinical and pathological observation diagnosed as a marginal zone lymphoma in a 7-year-old girl of Indian origin, presenting as a 36 × 13 mm erythematous plaque with an adjacent 6 × 4 mm erythematous firm papule on the anterior aspect of the lower part of the left leg [5].…”

Section: Discussionmentioning

confidence: 65%

“…Immunohistochemistry showed a mixture of T-cell and B-cell lymphocytes with numerous plasma cells. Special immunoperoxidase studies in paraffin sections for immunoglobulin light chain showed a polyclonal process in 4 cases/4 [1,2,4]. Immunoglobulin chain rearrangement showed a polyclonal process in 2 cases/2 and monoclonality in 1 case [5].…”

Section: Discussionmentioning

confidence: 99%

“…The lesion recurred and then stabilized without any treatment [2,3]. In 2 patients, the lesion was surgically removed without recurrence [4,5]. One was treated with pulsed-dye laser for cosmetic purposes with some fading of the violaceous color [1].…”

Section: Discussionmentioning

confidence: 99%

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Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

Moulonguet¹,

Hadj‐Rabia²,

Gounod

et al. 2012

Dermatology

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Tibial lymphoplasmacytic plaque (TLP) is a recently recognized clinicopathological entity affecting children and is characterized by a linear, reddish brown plaque on the leg with a dense dermal lymphoplasmacytic infiltrate. No effective treatments are available for this lesion of unknown etiology and its course is chronic. We report a new case in which, for the first time, a causative factor (insect bite) is strongly suspected. The clinical and pathological features of TLP may be misleading for the uninformed dermatologist or pathologist. Therefore, we would like to draw attention to this very distinctive clinicopathological presentation in order to help them recognize it easily and prevent it from being misdiagnosed as an infectious disease or, above all, a cutaneous lymphoma. We will discuss the relationship between TLP and linear acral pseudolymphomatous angiokeratoma of children, a variant of pseudolymphoma localized on acral sites in children which may share some of TLP’s histopathological features.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tibial Lymphoplasmacytic Plaque: A New, Illustrative Case of a Recently and Poorly Recognized Benign Lesion in Children

Moulonguet¹,

Hadj‐Rabia²,

Gounod

et al. 2012

Dermatology

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show abstract

“…Eine hydrope Basalzelldegeneration wurde beschrieben [4], in  Fall auch eine lichenoide Interfacedermatitis mit kolloidalen Körperchen [6]. Immunhistochemisch besteht ein Gemisch von B-und T-Zellen, bei einer CD4:CD8-Ratio von  [4,5].…”

Section: Laborunclassified

“…Die Plasmazellen produzieren zu gleichen Teilen Kappa-und Lambda-lmmunglobulinleichtketten [3,8]. Mittels Rearrangementuntersuchungen konnte ein polyklonales Infiltrat sowohl für Tals auch für B-Zellen nachgewiesen werden [3,6].…”

Section: Laborunclassified