Akrale pseudolymphomat�se Angiokeratome der Kindheit (APACHE)

Gansz, Barbara; Ständer, Sonja; Metze, Dieter

doi:10.1007/s00105-004-0784-6

Cited by 11 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these lesions represent pseudolymphomas with likely reactive vascular proliferations to predisposing physical trauma. 96 The histopathological pattern is notable for thick-walled vessels lined by plump endothelia and densely packed lymphocytes, histiocytes, scattered plasma cells, and eosinophils, with B-cells predominating the lymphocytic infiltrate in younger patients. 97 Other conditions can mimic APACHE and fall within this spectrum of this disease, including pretibial lymphoplasmacytic plaque, primary cutaneous angioplasmacellular hyperplasia, and cutaneous marginal zone hyperplasia.…”

Section: Acral Pseudolymphomatous Angiokeratoma Of Childrenmentioning

confidence: 97%

“…The name angiokeratoma comes from the clinical appearance suggestive of a vascular tumor. However, these lesions represent pseudolymphomas with likely reactive vascular proliferations to predisposing physical trauma 96 . The histopathological pattern is notable for thick‐walled vessels lined by plump endothelia and densely packed lymphocytes, histiocytes, scattered plasma cells, and eosinophils, with B‐cells predominating the lymphocytic infiltrate in younger patients 97 .…”

Section: Non‐neoplastic Inflammatory Conditions With Clhmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous reactive B‐cell lymphoid proliferations

Khalil

Donthi²,

Gru

2022

J Cutan Pathol

View full text Add to dashboard Cite

Cutaneous lymphoid hyperplasia (CLH), also known as cutaneous pseudolymphoma, is a spectrum of benign conditions characterized by reactive B‐ and T‐cell cutaneous lymphocytic infiltrates. B‐cell lymphoid proliferations are a heterogenous group of non‐neoplastic cutaneous diseases that must be histopathologically distinguished from cutaneous B‐cell lymphomas. These proliferations can be observed as reactive phenomena to infections, medications, allergens, neoplasms, and more. Furthermore, there are many inflammatory conditions that present with reactive B‐cell infiltrates, including actinic prurigo, Zoon balanitis, Rosai‐Dorfman disease, and cutaneous plasmacytosis. This review summarizes multiple cutaneous B‐cell lymphoid proliferations within the major categories of reactive and disease‐associated CLH. Further we discuss major discriminating features of atypical CLH and malignancy. Understanding the specific patterns of B‐cell CLH is essential for the proper diagnosis and treatment of patients presenting with such lesions.

show abstract

Section: Acral Pseudolymphomatous Angiokeratoma Of Childrenmentioning

confidence: 97%

Section: Non‐neoplastic Inflammatory Conditions With Clhmentioning

confidence: 99%

Cutaneous reactive B‐cell lymphoid proliferations

Khalil

Donthi²,

Gru

2022

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…Esto difiere de los seudolinfomas, que suelen localizarse con mayor frecuencia en la cara y el cuello [6] . Aunque su nombre implica una localización distal, cabe resaltar que los pacientes 9 y 10 presentaron lesiones solitarias en el tronco [16][17][18][19][20][21][22][23][24] ; en el paciente 7, se F: femenino; M: masculino; L: linfocitos; H: histiocitos; E: eosinófilos; PC: células plasmáticas; MNGC: células gigantes multinucleadas; BCL: capa de células basales; VS: vasos sanguíneos; IL: intralesional; ND: no disponible; j: cadena kappa; k: cadena lambda; PCR: reacción en cadena de la polimerasa Tabla 1. Revisión de casos publicados en la bibliografía internacional con el diagnóstico de enfermedad de APACHE (niños y adultos) acompañó de alteraciones de la lámina ungular pues las lesiones se extendían hasta el pliegue ungular proximal [4] .…”

Section: Discussionunclassified

Angioqueratoma distal seudolinfomatoso infantil:

Saponaro,

Marini,

Parra

et al. 2018

rev. asoc. colomb. dermatol. cir. dematol.

View full text Add to dashboard Cite

El acróstico APACHE (Acral Pseudolymphomatous Angiokeratoma of Children) corresponde a una variante de los seudolinfomas cutáneos. El término fue introducido por Ramsay, et al., en 1988, cuando publicaron cinco casos de pacientes pediátricos con múltiples pápulas angiomatosas, unilaterales, que se localizaban en la región distal de las extremidades. En el estudio histopatológico se observaba un infiltrado dérmico linfohistiocitario nodular con capilares prominentes.En la actualidad, los nombres de “seudolinfoma de pequeñas pápulas” o “hiperplasia angiolinfoide papulosa” serían los más convenientes, ya que no siempre se presenta en niños, es de localización distal o se observan cambios angiomatososen el estudio de histopatología.Se presenta el caso de una niña con una lesión distal en el segundo dedo del pie izquierdo, cuyo diagnóstico de angioqueratoma distal seudolinfomatoso infantil se hizo mediante el estudio histopatológico. Además, se hacen comentarios sobreesta rara entidad.

show abstract

“…The features of all cases reported to date are presented in Table 1. [6][7][8][9][10][11][12][13][14][15][16][17][18] Seventy-seven percent of patients were female. Acral lesions (foot and hand) were seen in 52% of cases, and 97% of cases included limb lesions.…”

Section: Discussionmentioning

confidence: 99%

Acral Pseudolymphomatous Angiokeratoma of Children

Tokuda

Arakura²,

Murata³

et al. 2012

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Acral pseudolymphomatous angiokeratoma of children (APACHE) is characterized by multiple angiomatous papules on the hands and feet in children. Here, we report a case of APACHE in a female patient followed up from 13 to 19 years of age with a dark red lesion on the center of the dorsum of the right thigh. Histologically, vacuolar alteration and exocytosis of lymphocytes, and specific dense cellular infiltration beneath the epidermis to the reticular dermis were found. On immunolabeling study, the lesion vessels were found to be positive for both the lymphatic endothelium-specific marker podoplanin and blood vessel-specific marker CD34. These findings suggested that APACHE is a type of vascular malformation.

show abstract

Akrale pseudolymphomat�se Angiokeratome der Kindheit (APACHE)

Cited by 11 publications

References 10 publications

Cutaneous reactive B‐cell lymphoid proliferations

Cutaneous reactive B‐cell lymphoid proliferations

Angioqueratoma distal seudolinfomatoso infantil:

Acral Pseudolymphomatous Angiokeratoma of Children

Contact Info

Product

Resources

About