Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2

Kim, Joomyeong; Bergmann, Anne; Lucas, Susan; Stone, R. T.; Stubbs, Lisa

doi:10.1016/j.ygeno.2004.02.007

Cited by 58 publications

(52 citation statements)

References 24 publications

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“…Since deletion of the murine Peg1 paternal allele results in abnormal maternal behaviour in regard to placentophagia and poor nest building (Lefebvre et al 1998), one possibility is that the species differences in this gene reflect variable types of maternal behaviour post-partum. However, sheep express PEG3 paternally in both the day 21 foetus and the chorioallantois, and a similar pattern of expression is seen in virtually all tissues from the mouse, human, as well as in bovine adult brain and testis (Kim et al 2004), although disrupted imprinting in this gene also affects murine maternal behaviour (Li et al 1999, Murphy et al 2001.…”

Section: Peg1 and Peg3mentioning

confidence: 90%

Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage

Thurston¹,

Taylor²,

Gardner³

et al. 2007

Reproduction

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The preimplantation embryos of a range of mammals can be susceptible to disruptions in genomic imprinting mechanisms, resulting in loss of imprinting. Such disruptions can have developmental consequences involving foetal and placental growth such as BeckwithWiedemann syndrome in humans and large offspring syndrome in sheep. Our objective was to investigate the dynamics of establishing monoallelic expression of individual sheep imprinted genes post-fertilisation. Semi-quantitative RT-PCR was used to amplify cDNA from the sheep blastocyst, day 21 foetus and day 21 chorioallantois, to compare expression levels between biparental and parthenogenetic embryos in order to indicate allelic expression status. In common with other mammals, IGF2, PEG1 and PEG3 were paternally expressed in the day 21 conceptus, while H19, IGF2R, GRB10 and p57 KIP were maternally expressed. Interestingly, GNAS was maternally expressed in the foetus, but paternally expressed in the chorioallantois at day 21. Overall, the imprinting of ovine GRB10 and IGF2R was comparable with mouse but not with human. Contrary to the trophoblast-restricted maternal expression in both mouse and human, SASH2 (sheep homologue of Mash2/HASH2) was expressed in the ovine foetus and was biallelically expressed in the chorioallantois. Differential methylation of the H19 CTCF III upstream region and IGF2R DMR2 in the chorioallantois revealed predominantly paternal and maternal methylation respectively, indicating conservation of these imprinting regulatory regions. In blastocysts, IGF2R, GRB10 and SASH2 were expressed biallelically, while the other genes were not detected. Thus, for the majority of ovine imprinted genes examined, monoallelic expression does not occur until after the blastocyst stage.Reproduction (

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Section: Peg1 and Peg3mentioning

confidence: 90%

Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage

Thurston¹,

Taylor²,

Gardner³

et al. 2007

Reproduction

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show abstract

“…1 ), and the gene could exhibit maternal expression. In fact, the Zim2 gene is maternally expressed in mouse but paternally expressed in human (Kim et al, 2004). In order to know how many genes can be explained by the simple dosage control hypothesis, we have to expand the imprinting status analysis to cover all orders in mammals with quantitative evaluation of gene expression levels among species.…”

Section: Every Imprinted Gene Can Be Species-specifi Cmentioning

confidence: 99%

Lessons from comparative analysis of species-specific imprinted genes

Okamura

Ito

2006

Cytogenet Genome Res

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Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.

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“…E-mail: kigo-hit@163.com maternal nurturing behavior (Li et al, 1999;Relaix et al, 2000). The gene is paternally expressed in human (19q13), mouse (7A2-B1), sheep and cattle (Kuroiwa et al, 1996;Murphy et al, 2001;Kim et al, 2004;Thurston et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, mRNA expression and imprinting status of PEG3, NAP1L5 and PPP1R9A genes in pig

Zhang

Deng

et al. 2011

Genes Genet. Syst.

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Imprinted genes are expressed monoallelically depending on their parental origin, and play important roles in the regulation of fetal growth, development, and postnatal behavior. Most genes known to be imprinted have been identified and studied in the human and the mouse. However, there are only a small number of reported imprinted genes in pigs. Therefore, identification and characterization of more imprinted genes in pigs is useful for comparative analysis of genomic imprinting across species. In this study, we cloned the porcine PEG3, NAP1L5 and PPP1R9A genes. The imprinting status of these genes was determined using sequencing directly and single nucleotide polymorphisms (SNPs) identified in individuals from reciprocal cross of Meishan and Large White pigs. Imprinting analysis was carried out in 13 different tissues (skeletal muscle, fat, pituitary gland, heart, lung, liver, kidney, spleen, stomach, small intestine, uterus, ovary and testis) from twelve 2-month-old piglets. Imprinting analysis showed that PEG3 and NAP1L5 were exclusively expressed from the paternal allele whereas PPP1R9A was biallelically expressed in all tissues tested where the genes were expressed. The study is of interest to understand the conservation of genomic imprinting among mammals at the 3 loci.

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Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2

Cited by 58 publications

References 24 publications

Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage

Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage

Lessons from comparative analysis of species-specific imprinted genes

Molecular cloning, mRNA expression and imprinting status of PEG3, NAP1L5 and PPP1R9A genes in pig

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