LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling

Zhang, Lichao; Yan, Xiaoyu; Yu, Shuyou; Zhong, Xinru; Tian, Rui; Xu, Long; Bian, Xu-ming; Su, Jing

doi:10.3892/ol.2019.11166

Cited by 5 publications

(8 citation statements)

References 46 publications

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“…LINC00501 has been identified as a prognostic factor associated with the overall survival of patients with hepatocellular carcinoma (HCC) ( 50 – 52 ). LINC00365 influences the Wnt/β-catenin signaling pathway, which modulates colorectal cancer (CRC) progression ( 53 ), and breast cancer cell viability may be regulated by the LINC00365-secretoglobin family 2A member 1 (SCGB2A1) axis, which targets NF-κB signaling ( 54 ). In GC, the expression levels of LINC00365 and SCGB2A1 are downregulated in tumor tissues, which is associated with a shorter survival time ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Jiang

Zhang

et al. 2021

Oncol Lett

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Gastric cancer (GC) is a common type of cancer, and identification of novel diagnostic biomarkers associated with this disease is important. The present study aimed to identify novel diagnostic biomarkers associated with the prognosis of GC, using an integrated bioinformatics approach. Differentially expressed long non-coding RNAs (lncRNAs) associated with GC were identified using Gene Expression Omnibus datasets (GSE58828, GSE72305 and GSE99416) and The Cancer Genome Atlas database. A competing endogenous RNA network that incorporated five lncRNAs [long intergenic non-protein coding RNA 501 (LINC00501), LINC00365, SOX21 antisense divergent transcript 1 (SOX21-AS1), GK intronic transcript 1 (GK-IT1) and DLEU7 antisense RNA 1 (DLEU7-AS1)], 29 microRNAs and 114 mRNAs was constructed. Gene Ontology and protein-protein interaction network analyses revealed that these lncRNAs may be involved in ‘biological regulation’, ‘metabolic process’, ‘cell communication’, ‘developmental process’, ‘cell proliferation’, ‘reproduction’ and the ‘cell cycle’. The results of receiver operating characteristic curve analysis demonstrated that LINC00501 (AUC=0.819), LINC00365 (AUC=0.580), SOX21-AS1 (AUC=0.736), GK-IT1 (AUC=0.823) and DLEU7-AS1 (AUC=0.932) had the potential to become valuable diagnostic biomarkers for GC. Associations with clinicopathological characteristics demonstrated that LINC00501 expression was significantly associated with sex (P=0.015) and tumor grade (P=0.022). Furthermore, LINC00365 expression was significantly associated with lymph node metastasis (P=0.025). Gene set enrichment analysis revealed that LINC00501, LINC00365 and SOX21-AS1 were enriched in signaling pathways associated with GC. Reverse transcription-quantitative PCR analysis demonstrated that LINC00501 expression (P=0.043) was significantly upregulated in GC tissues, whereas the expression levels of LINC00365 (P=0.033) and SOX21-AS1 (P=0.037) were significantly downregulated in GC tissues. Taken together, the results of the present study suggest that LINC00501, LINC00365, SOX21-AS1, GK-IT1 and DLEU7-AS1 may be used as novel diagnostic biomarkers for GC, and may be functionally associated with GC development and progression.

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Section: Discussionmentioning

confidence: 99%

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Jiang

Zhang

et al. 2021

Oncol Lett

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“…Oppositely, LINC00365 was lower expressed in breast cancer. The up‐regulation of LINC00365 attenuated the proliferation and induced the apoptosis of breast cancer cells 14 . Therefore, the function of LINC00365 on cancers development varies with tumor types.…”

Section: Discussionmentioning

confidence: 99%

“…The up-regulation of LINC00365 attenuated the proliferation and induced the apoptosis of breast cancer cells. 14 Glycolysis is conductive to accelerate tumor cells proliferation and metastatic dissemination. 30,31 In this study, LINC00365 suppressed the glycolysis of H1975 cells, manifested as the reduced glucose uptake, lactate product, and cellular ATP level.…”

Section: Discussionmentioning

confidence: 99%

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LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis

Zhang

Zhou

Liu

et al. 2022

Environmental Toxicology

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This study researched the function of long non-coding RNA LINC00365 in lung adenocarcinoma (LAD) progression. LINC00365, miR-429, and KCTD12 expression in the LAD clinical tissues and cells were detcetd by qRT-PCR and Western blot. LINC00365, miR-429, and KCTD12 effects on H1975 cells malignant phenotype were detected by cell counting kit-8 assay, clone formation experiment, Transwell experiment, and glycolysis. Dual luciferase reporter gene assay and RNA pull-down assay were implemented. LINC00365 effect on H1975 cells in vivo growth was detected. LINC00365 was low expressed in the LAD patients and cells, associating with poor outcome. LINC00365 up-regulation attenuated H1975 cells proliferation, migration, invasion, glycolysis and in vivo growth. LINC00365 inhibited KCTD12 expression by sponging miR-429. miR-429 up-regulation and KCTD12 downregulation partial reversed LINC00365 inhibition on H1975 cells malignant phenotype. Thus, LINC00365 inhibited LAD progression and glycolysis via targeting miR-429/KCTD12 axis. LINC00365 might be a potential candidate for LAD target treatment clinically.

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“… 16 , 17 Over the past few decades, studies have shown that multiple lncRNAs are abnormally expressed in breast cancer. 18–20 Therefore, it is important for the identification of breast cancer clinical treatment to dissect the role of lncRNAs in breast cancer progression. In our study, we found that the expression levels of lncRNA SNHG8 were elevated in breast cancer tissues and cell lines.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG8 Serves as an Oncogene in Breast Cancer Through miR-634/ZBTB20 Axis

Xu¹,

Xie²,

Xie³

et al. 2021

CMAR

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Background Small nucleolus RNA Host Gene 8 (SNHG8) belongs to a subgroup with long non-coding RNAs. LncRNA SNHG8 presents up-regulated in miscellaneous cancers, like gastric cancer, liver cancer, and esophageal squamous cell cancer. Nevertheless, the expression pattern and the pathological function of lncRNA SNHG8 in breast cancer remain obscure. Methods We examined the expression levels of lncRNA SNHG8 in the tissue samples and cell lines from breast cancer via RT-qPCR in the present study. The functions of lncRNA SNHG8 on the progression of breast cancer cell were examined by CCK-8, EdU, Transwell chamber assays, and flow cytometry analyses. The expression of proteins was assessed using Western blot assay. Results We found that proliferation, migration, and invasion of breast cancer cells were significantly inhibited due to knockdown of lncRNA SNHG8, while inducing apoptosis of these cells. Mechanistically, SNHG8 functioned as an inhibitor of miR-634 in tumor tissues. Conclusion LncRNA SNHG8 sponged the miR-634 to increase the expression level of ZBTB20, thus further aggravating the malignancy of breast cancer. Hence, the lncRNA SNHG8-miR-634-ZBTB20 axis may be a promising therapeutic target to treat breast cancers.

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LINC00365‑SCGB2A1 axis inhibits the viability of breast cancer through targeting NF‑κB signaling

Cited by 5 publications

References 46 publications

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

LINC00365 inhibited lung adenocarcinoma progression and glycolysis via sponging miR‐429/KCTD12 axis

LncRNA SNHG8 Serves as an Oncogene in Breast Cancer Through miR-634/ZBTB20 Axis

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