LINC00324 in cancer: Regulatory and therapeutic implications

Abstract

LINC00324 is a 2082 bp intergenic noncoding RNA. Aberrant expression of LINC00324 was associated with the risk of 11 tumors and was closely associated with clinicopathological features and prognostic levels of 7 tumors. LINC00324 can sponge multiple miRNAs to form complex ceRNA networks, and can also recruit transcription factors and bind RNA-binding protein HuR, thereby regulating the expression of a number of downstream protein-coding genes. LINC00324 is involved in 4 signaling pathways, including the PI3K/AKT signaling pathway, cell cycle regulatory pathway, Notch signaling pathway, and Jak/STAT3 signaling pathway. High expression of LINC00324 was associated with larger tumors, a higher degree of metastasis, a higher TNM stage and clinical stage, and shorter OS. Currently, four downstream genes in the LINC00324 network have targeted drugs. In this review, we summarize the molecular mechanisms and clinical value of LINC00324 in tumors and discuss future directions and challenges for LINC00324 research.

Identification of hypoxic-related lncRNAs prognostic model for revealing clinical prognostic and immune infiltration characteristic of cutaneous melanoma

“…In addition to its classic function of complex ceRNA network forming, LINC00324 can also bind RNA-binding proteins and recruit transcription factors in order to regulate multiple downstream gene expressions [ 41 ]. Although no relevant studies have been conducted in CM, LINC00324 has been shown to be overexpressed in a variety of cancer types and to be associated with pathologic features and risk stratification [ 42 ]. Unlike most tumor types, we observed a significant reduction in LINC00324 mRNA level in the A375 melanoma cell line compared to the HFB4 control cell line, which is in line with the observation in breast cancer [ 43 ].…”

Role of SLC7A11/xCT in Ovarian Cancer

“…Long non-coding RNAs (lncRNAs) are non-coding RNA sequences that sponge and sequester microRNAs (miRNAs). Both lncRNAs and miRNAs regulate important cell processes in cancerous and noncancerous diseases [ 112 , 113 , 114 , 115 ]. It has been reported that lncRNA ADAMTS9-AS1 plays a key role in the progression and development of several types of cancer, including lung [ 116 ], glioma [ 117 ], bladder [ 118 ], breast [ 119 ] and prostate [ 119 ].…”

The Role of NQO1 in Ovarian Cancer

“…Long non-coding RNAs (lncRNAs) are RNA sequences which do not code any polypeptide or protein and act by sponging and sequestering micro RNAs (miRNAs). Both miRNAs and lncRNAs play a key role in cancerous and non-cancerous diseases [62][63][64][65][66]. LncRNA H19 is encoded by the H19 gene and plays a key role in cancer onset and progression modulating cell growth, invasion and migration [67].…”