(−)-Linalool, a naturally occurring monoterpene compound, impairs memory acquisition in the object recognition task, inhibitory avoidance test and habituation to a novel environment in rats

Coelho, Vanessa Rodrigues; Gianesini, Janaína; Borowski, Rafael Gomes Von; Mazzardo-Martins, Leidiane; Martins, Daniel Fernandes; Picada, Jaqueline Nascimento; Santos, Adair R.S.; Brum, L. F. Silva; Pereira, Patrı́cia

doi:10.1016/j.phymed.2011.02.010

Cited by 26 publications

(15 citation statements)

References 30 publications

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“…While linalool impaired the acquisition of long-term memory without interfering with short-term memory in rats in an object recognition task. This effect was associated with an antagonist capacity, similar to a glutamate antagonist (Coelho et al, 2011). Nevertheless, higher doses (i.p.…”

Section: Discussionmentioning

confidence: 99%

Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice

2016

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Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder. Several types of treatments have been tested to block or delay the onset of the disease, but none have been completely successful. Diet, lifestyle and natural products are currently the main scientific focuses. Here, we evaluate the effects of oral administration of the monoterpene linalool (25 mg / kg), every 48 hours for 3 months, on aged (21–24 months old) mice with a triple transgenic model of AD (3xTg-AD) mice. Linalool-treated 3xTg-AD mice showed improved learning and spatial memory and greater risk assessment behavior during the elevated plus maze. Hippocampi and amygdalae from linalool-treated 3xTg-AD mice exhibited a significant reduction in extracellular β-amyloidosis, tauopathy, astrogliosis and microgliosis as well as a significant reduction in the levels of the pro-inflammatory markers p38 MAPK, NOS2, COX2 and IL-1β. Together, our findings suggest that linalool reverses the histopathological hallmarks of AD and restores cognitive and emotional functions via an anti-inflammatory effect. Thus, linalool may be an AD prevention candidate for preclinical studies.

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Section: Discussionmentioning

confidence: 99%

Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice

2016

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“…These studies proved that linalool could cause impedance in the muscarinic, opioid, and dopaminergic transmission (Peana et al ., , ). In rats, linalool was also reported to antagonize the impaired memory acquisition caused by N‐methyl‐D‐aspartate receptors (Coelho et al ., ).…”

Section: Introductionmentioning

confidence: 97%

The Potential for Plant Derivatives against Acrylamide Neurotoxicity

Adewale

Brimson

Odunola

et al. 2015

Phytotherapy Research

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Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.

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“…In fact, l -[ 3 H] glutamate binding decreases with increasing concentrations of linalool, and the inhibition is dose-dependent [11]. Moreover, linalool interacts with NMDA receptor complex [15,16] and shows an inhibitory effect on acetylcholine release and channel open time in the mouse neuromuscular junction [17]. The inhalation of linalool provokes relaxing effects, and the combination of linalool and linalool oxide may be a useful mean to counteract anxiety [15,18,19] Linalool inhibited adenylyl cyclase activity by affecting the cAMP cellular content.…”

Section: Introductionmentioning

confidence: 99%

Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System

Caputo

Souza

Alloisio

et al. 2016

IJMS

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The aims of this study are to determine the chemical composition of Lavandula angustifolia Mill. and Coriandrum sativum L. essential oils, to evaluate their cytotoxic effects in SH-SY5Y human neuroblastoma cells, to investigate whether an alteration of adenylate cyclase 1 (ADCY1) and of extracellular signal-regulated kinase (ERK) expression can take part in the molecular mechanisms of the essential oils, and to study their possible neuronal electrophysiological effects. The essential oils were obtained by hydrodistillation, and studied by GC and GC-MS. In the oils from L. angustifolia and C. sativum, linalool was the main component (33.1% and 67.8%, respectively). SH-SY5Y cells were incubated with different concentrations of essential oils and of linalool. Cell viability and effects on ADCY1 and ERK expression were analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT and Western blotting, respectively. Variation in cellular electrophysiology was studied in primary cultures of rat cortical neurons with a multi-electrode array (MEA)-based approach. The essential oils and linalool revealed different cytotoxic activities. Linalool inhibited ADCY1 and ERK expression. Neuronal networks subjected to L. angustifolia and C. sativum essential oils showed a concentration-dependent inhibition of spontaneous electrical activity.

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(−)-Linalool, a naturally occurring monoterpene compound, impairs memory acquisition in the object recognition task, inhibitory avoidance test and habituation to a novel environment in rats

Cited by 26 publications

References 30 publications

Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice

Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice

The Potential for Plant Derivatives against Acrylamide Neurotoxicity

Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System

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