Lin28B is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma

Tian, Nan; Shangguan, Wenbing; Zhou, Zuolin; yao, Yao; Fan, Cheng; Cai, Lijun

doi:10.1101/478479

Cited by 4 publications

(7 citation statements)

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“…LIN28B serves as a key driver gene in HBx-induced hepatocarcinogenesis [21]. LIN28B is overexpressed in HCC [10,18,22] and its expression promotes transformation and invasion of HCC [18] while the suppression of LIN28B expression inhibits HCC cell proliferation and metastasis [23]. Higher expression of LIN28B is associated with shorter overall survival in HCC patients [22].…”

Section: Introductionmentioning

confidence: 99%

“…LIN28B is overexpressed in HCC [10,18,22] and its expression promotes transformation and invasion of HCC [18] while the suppression of LIN28B expression inhibits HCC cell proliferation and metastasis [23]. Higher expression of LIN28B is associated with shorter overall survival in HCC patients [22]. LIN28B in the peripheral blood mononuclear cells is shown to be an oncofetal circulating cancer stem cell-like marker associated with recurrence of HCC [24].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the LIN28B rs314277 polymorphism was shown to have a significant association with risk of recurrence in patients with stage II colorectal cancer [25]. Although LIN28B has been demonstrated to be involved in HBV replication [17], HBV-related hepatocarcinogenesis [18][19][20][21] and the migration, invasion, metastasis and prognosis in HCC [18,22,24], the association of LIN28B polymorphisms with the susceptibility of chronic HBV infection and the clinical disease of chronic HBV infection including the development of HCC remains unknown. Therefore, this study investigated the relationship between LIN28B polymorphisms and the susceptibility of chronic HBV infection and HBV-related liver disease including HCC in Han Chinese population.…”

Section: Introductionmentioning

confidence: 99%

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Association of LIN28B polymorphisms with chronic hepatitis B virus infection

Han

Sang

Fan

et al. 2020

Virol J

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Background LIN28B is involved in multiple cellular developmental processes, tissue inflammatory response and tumourigenesis. The association of LIN28B polymorphisms with hepatitis B virus (HBV) infection remains unknown. Methods This study investigated the association of LIN28B rs314277, rs314280, rs369065 and rs7759938 polymorphisms in patients with chronic HBV infection, a major cause of liver disease including hepatocellular carcinoma (HCC). A total of 781 individuals including 515 cases of chronic HBV infection (91 asymptomatic carrier status, 128 chronic hepatitis, 127 cirrhosis and 169 HCC), 97 HBV infection resolvers and 169 healthy controls were investigated. Results LIN28 rs314280 genotypes GA + AA were higher in resolver and controls than patients (P = 0.011). Patients had significantly lower rs314280 allele A than resolvers (P = 0.031, OR 0.689, 95%CI 0.491–0.969) or controls (P = 0.034, OR 0.741, 95%CI 0.561–0.978). In dominant model, patients had significantly lower rs314280 genotypes AA+GA than controls (P = 0.008, OR 0.623, 95%CI 0.439–0.884). LIN28 rs7759938 genotypes TC + CC were higher in resolvers and controls than patients (P = 0.015). Patients had significantly lower rs7759938 allele C than resolvers (P = 0.048, OR 0.708, 95%CI 0.503–0.999). In dominant model, patients had significantly lower rs7759938 genotypes TC + CC than controls (P = 0.010, OR 0.632, 95%CI 0.445–0.897). Chronic hepatitis patients had lower frequency of rs369065 genotype TC than asymptomatic carriers, cirrhosis and HCC (P = 0.019). Conclusions These results suggest that LIN28 rs314280 and rs7759938 may be related to the susceptibility of chronic HBV infection. Further studies are warranted to examine the association of LIN28B polymorphisms with HBV-related diseases, especially HCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of LIN28B polymorphisms with chronic hepatitis B virus infection

Han

Sang

Fan

et al. 2020

Virol J

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“…In PDAC patients, high LIN28B expression was significantly correlated with high levels of lymphatic metastasis, distant metastasis and a poor prognosis. In addition, patients with increased LIN28B had markedly reduced overall survival compared to those with low LIN28B in HCC [62] and oral squamous cell carcinoma (OSCC) [63]. Thus, LIN28B is highly expressed in CRC and plays an important role in its pathogenesis, indicating that it is suitable as a target gene for CRC prognosis.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of RNA-binding proteins in human colorectal cancer

et al. 2020

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Background: Although RNA-binding proteins play an essential role in a variety of different tumours, there are still limited efforts made to systematically analyse the role of RNA-binding proteins (RBPs) in the survival of colorectal cancer (CRC) patients. Methods: Analysis of CRC transcriptome data collected from the TCGA database was conducted, and RBPs were extracted from CRC. R software was applied to analyse the differentially expressed genes (DEGs) of RBPs. To identify related pathways and perform functional annotation of RBP DEGs, Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out using the database for annotation, visualization and integrated discovery. Protein-protein interactions (PPIs) of these DEGs were analysed based on the Search Tool for the Retrieval of Interacting Genes (STRING) database and visualized by Cytoscape software. Based on the Cox regression analysis of the prognostic value of RBPs (from the PPI network) with survival time, the RBPs related to survival were identified, and a prognostic model was constructed. To verify the model, the data stored in the TCGA database were designated as the training set, while the chip data obtained from the GEO database were treated as the test set. Then, both survival analysis and ROC curve verification were conducted. Finally, the risk curves and nomograms of the two groups were generated to predict the survival period. Results: Among RBP DEGs, 314 genes were upregulated while 155 were downregulated, of which twelve RBPs (NOP14, MRPS23, MAK16, TDRD6, POP1, TDRD5, TDRD7, PPARGC1A, LIN28B, CELF4, LRRFIP2, MSI2) with prognostic value were obtained. Conclusions: The twelve identified genes may be promising predictors of CRC and play an essential role in the pathogenesis of CRC. However, further investigation of the underlying mechanism is needed.

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“…LIN28B is highly expressed in liver cells and is related to the level of alpha-fetoprotein, which promotes the tumorigenesis and progression of HCC. The overall survival rate of HCC patients with high LIN28B expression in signi cantly shortened, which is related to the multidrug resistance of HCC [41] . SMG5 is highly expressed in malignant tumors, especially prostate cancer and it is a potential molecular marker for the early diagnosis of cancers [42] .…”

Section: Discussionmentioning

confidence: 99%

Systematic Analysis of the Function and Prognostic Value of RNA-Binding Proteins in Hepatocellular Carcinoma

Wu¹,

Yang²,

Yang³

et al. 2020

Preprint

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Background: RNA-binding proteins (RBPs) are abnormally expressed in a variety of malignant tumors and are closely related to tumorigenesis, tumor progression, and prognosis. The role of RBPs in hepatocellular carcinoma (HCC) is unclear. Based on the cancer genome atlas (TCGA) database, we conducted a systematic bioinformatics analysis of abnormally expressed RBPs in HCC, with the aim of identifying the prognostic markers and potential therapeutic targets.Methods: HCC RNA sequencing data downloaded from TCGA database were used to determine the differentially expressed RBPs in livery cancer and normal tissues, followed by performing functional enrichment analysis and visualization of interaction relationships. Univariate and multivariate Cox regression analyses were subsequently used to identify RBPs that were significantly related to the prognosis to construct a prognostic model. The predictive performance of the prognostic model was evaluated by survival analysis and receiver operating characteristic (ROC) curve analysis and verified in the test cohort. Human protein atlas online database was used to verify the expression level of RBPs in the prognostic model.Results: In total, 82 differentially expressed RBPs were identified, including 55 upregulated and 27 downregulated RBPs. Further functional enrichment and interaction analyses showed that the differentially expressed RBPs were mainly related to regulating of mRNA metabolic process, RNA catabolic, mRNA catabolic process, and macromolecule methylation. Five RBP genes, LIN28B, SMG5, PPARGC1A, LARP1B, and ANG were identified as prognostic-related genes and used to construct the prognostic model. The predictive ability of the prognostic model was verified in the test cohort. ROC curve analysis showed that the prognostic model had good sensitivity and specificity. Independent prognostic analysis showed that the risk score may be an independent prognostic factor for HCC.Conclusion: This study constructed a reliable prognostic prediction model by analyzing the differentially expressed RBPs of HCC, facilitating the identification of HCC prognostic biomarkers and therapeutic targets.

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Lin28B is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma

Cited by 4 publications

References 49 publications

Association of LIN28B polymorphisms with chronic hepatitis B virus infection

Association of LIN28B polymorphisms with chronic hepatitis B virus infection

Integrated analysis of RNA-binding proteins in human colorectal cancer

Systematic Analysis of the Function and Prognostic Value of RNA-Binding Proteins in Hepatocellular Carcinoma

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