Association of LIN28B polymorphisms with chronic hepatitis B virus infection

Abstract

Background LIN28B is involved in multiple cellular developmental processes, tissue inflammatory response and tumourigenesis. The association of LIN28B polymorphisms with hepatitis B virus (HBV) infection remains unknown. Methods This study investigated the association of LIN28B rs314277, rs314280, rs369065 and rs7759938 polymorphisms in patients with chronic HBV infection, a major cause of liver disease including hepatocellular carcinoma (HCC). A total of 781 individuals including 515 cases of chronic HBV infection (91 asymptomatic carrier status, 128 chronic hepatitis, 127 cirrhosis and 169 HCC), 97 HBV infection resolvers and 169 healthy controls were investigated. Results LIN28 rs314280 genotypes GA + AA were higher in resolver and controls than patients (P = 0.011). Patients had significantly lower rs314280 allele A than resolvers (P = 0.031, OR 0.689, 95%CI 0.491–0.969) or controls (P = 0.034, OR 0.741, 95%CI 0.561–0.978). In dominant model, patients had significantly lower rs314280 genotypes AA+GA than controls (P = 0.008, OR 0.623, 95%CI 0.439–0.884). LIN28 rs7759938 genotypes TC + CC were higher in resolvers and controls than patients (P = 0.015). Patients had significantly lower rs7759938 allele C than resolvers (P = 0.048, OR 0.708, 95%CI 0.503–0.999). In dominant model, patients had significantly lower rs7759938 genotypes TC + CC than controls (P = 0.010, OR 0.632, 95%CI 0.445–0.897). Chronic hepatitis patients had lower frequency of rs369065 genotype TC than asymptomatic carriers, cirrhosis and HCC (P = 0.019). Conclusions These results suggest that LIN28 rs314280 and rs7759938 may be related to the susceptibility of chronic HBV infection. Further studies are warranted to examine the association of LIN28B polymorphisms with HBV-related diseases, especially HCC.

LIN28B Polymorphisms Confer a Higher Postoperative Recurrence Risk in Reproductive-Age Women with Endometrial Polyps

“…This study had some limitations because it was a hospital-based cohort study, restricted to a Chinese Han population. However, the genotype frequencies of the two study polymorphisms among our subjects well fit the Hardy–Weinberg disequilibrium law, and T allele frequency of rs369065 in our study (61.1%) is similar to the frequencies reported in two studies conducted in two Chinese populations (64% [ 30 ] and 67% [ 39 ]), suggesting the subjects' selection is random. Additionally, we had achieved a more than 99% study power (two-sided test, α = 0.05) to detect a HR of 1.883 for the rs369065 TT genotype (which occurred at a frequency of 32.2% in the nonrecurrence subjects) compared with the rs369065 CC/CT genotypes in a population of more than 300 subjects.…”

“…A few population-based studies have analyzed the association of LIN28B polymorphisms with various phenotypes. They showed that LIN28B rs369065 C > T polymorphism is significantly associated with chronic hepatitis B virus infection [ 30 ], standing height [ 31 ], and age at menarche [ 32 , 33 ]. These reports implied that LIN28B rs369065 C > T might be a potential functional polymorphism, which can alter LIN28B gene's expression or function, then promote the proliferation of endometrial squamous cells, thus, risk of polyp recurrence.…”

Fc receptor-like 5 gene polymorphisms and mRNA expression are associated with liver fibrosis in chronic hepatitis B

“…Gene mutations may affect the binding of the region where the site is located with transcription factors, thus affecting the transcription process of mRNA. Previous studies have reported that SNPs of multiple genes are related to the occurrence, development, and prognosis of HBV-related fibrosis (Guo et al, 2015;Han et al, 2020;Su et al, 2022). The purpose of this study was to investigate the relationship between FCRL5 gene variations and liver fibrosis in CHB patients and its effect on gene mRNA expression levels.…”

“…As one of the most common heritable variations, single nucleotide polymorphisms (SNPs) have attracted the attention of many researchers in recent years. Up to now, many studies have shown abundant gene susceptibility loci associated with HBV infection and related diseases, including interleukin-10 ( Guo et al, 2015), Sodium taurocholate co-transporting polypeptide (Su et al, 2022), and RNA-binding protein lin28 gene polymorphisms (Han et al, 2020). Nevertheless, the associations having been reported cannot completely explain the mechanism of hepatitis B-related fibrosis.…”

Effect of Chronic Hepatitis B Virus (HBV) Infection on Lipid Profile in Iraqi Patients

“…Beyond the parameters of age and immune response, other determinants-including genetic proclivities and lifestyle configurations-may wield significant influence over the lipid aberrations observed. These elements add yet another layer of complexity to the intricate tapestry of factors that modulate lipid metabolism in the context of HBV infection [16].…”