Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights

Abstract

Probiotics microorganisms exert their health-associated activities through some of the following general actions: competitive exclusion, enhancement of intestinal barrier function, production of bacteriocins, improvement of altered microbiota, and modulation of the immune response. Among them, Limosilactobacillus fermentum CECT5716 has become one of the most promising probiotics and it has been described to possess potential beneficial effects on inflammatory processes and immunological alterations. Different studies, preclinical and clinical trials, have evidenced its anti-inflammatory and immunomodulatory properties and elucidated the precise mechanisms of action involved in its beneficial effects. Therefore, the aim of this review is to provide an updated overview of the effect on host health, mechanisms, and future therapeutic approaches.

Limosilactobacillus fermentumATG-V5 stimulates the immune response by enhancing gut microbiome and metabolite in a cyclophosphamide-induced immunosuppression mouse model

“…One study demonstrated that the administration of a fermented milk product containing Limosilactobacillus (formerly L. paracasei ) strain Shirota to healthy adults resulted in increased NK cell activity and improved cytokine production, indicating a potential immunomodulatory effect of the strain(Rico et al, 2014). Another study investigated the immunomodulatory effects of a strain of Limosilactobacillus fermentum in vitro and found that it induced the production of various cytokines and enhanced the phagocytic activity of macrophages(Rodríguez-Sojo, Ruiz-Malagón, Rodríguez-Cabezas, Gálvez, & Rodríguez-Nogales, 2021).…”

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

“…Therefore, these mechanisms could be affected in the case of CS-associated dysbiosis. L. fermentum CECT 5716 has been shown to support pathogen defense through all these mechanisms in different in vitro and in vivo models ( 41 ). Interestingly, results obtained in newborn rats show a protection in intestinal barrier integrity during stress induced by maternal separation ( 42 ).…”

Probiotics and postbiotics play a role in maintaining dermal health

“…Similarly, treatment with L. fermentum increased TNF expression followed by neutrophil infiltration, resulting in infection resolution. 52…”

“…Similarly, treatment with L. fermentum increased TNF expression followed by neutrophil infiltration, resulting in infection resolution. 52 Protection against pathogenic biofilms: ground reason for chronic non-healing wounds…”