Limonoids from Trichilia elegans ssp. elegans

Garcez, Fernanda Rodrigues; Garcez, Walmir Silva; Tsutsumi, Maura T.; Roque, Nı́dia Franca

doi:10.1016/s0031-9422(96)00737-6

Cited by 39 publications

(51 citation statements)

References 25 publications

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“…There are no phytochemical studies about T. ramalhoi, but several compounds have been isolated from the Trichilia genus, such as, limonoids (Cortez et al, 1992;Garcez et al, 1997;Garcez, et al, 2000;Cortez et al, 2000), lignan glycosides (Cortez et al, 1998), w-phenyl alkanoic and alkenoic acids (Pupo et al, 1996), terpenoids, steroids Pupo et al, 1996) and g-lactones (Pupo et al, 1998). Phytochemical studies with other active extracts from these plants are in progress and shall reveal molecules that can be used as potential lead compounds in the search for potent and selective T. cruzi gGAPDH inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase enzyme inhibitors

Leite¹,

Ambrozin²,

Castilho³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Busca de inibidores da enzima glicossomal gliceraldeído 3-fosfato desidrogenase de Trypanosoma cruzi". Nesse trabalho foi avaliada a atividade inibitória sobre a enzima glicossomal gliceraldeído-3-fosfato desidrogenase de T. cruzi (gGAPDH) de extratos vegetais oriundos de plantas das famílias Meliaceae e Rutaceae, na concentração de 100 mg/mL. Foram testados 46 extratos, dos quais 15 apresentaram atividade inibitória significativa (% AI ≥ 50). A maioria dos extratos de plantas da família Meliaceae (Cedrela fissilis, Cipadessa fruticosa e Trichilia ramalhoi) apresentou grande potencial em inibir a atividade enzimática. O fracionamento do extrato hexânico dos galhos de C. fruticosa permitiu o isolamento de três flavonóides: flavona, 7-metoxiflavona e 3',4',5',5,7-pentametoxiflavona. Os dois últimos foram ativos na inibição da atividade de gGAPDH. Desta forma, as três espécies de Meliaceae testadas podem ser consideradas promissoras na busca de compostos protótipos para o controle da doença de Chagas.Unitermo: Rutaceae, Meliaceae, flavonóides, gGAPDH, Trypanosoma cruzi, inibidores. ABSTRACT:The inhibitory activity of crude extracts of Meliaceae and Rutaceae plants on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) enzyme from Trypanosoma cruzi was evaluated at 100 mg/mL. Forty-six extracts were tested and fifteen of them showed significant inhibitory activity (IA % ≥ 50). The majority of the assayed extracts of Meliaceae plants (Cedrela fissilis, Cipadessa fruticosa and Trichilia ramalhoi) showed high ability to inhibit the enzymatic activity. The fractionation of the hexane extract from branches of C. fruticosa led to the isolation of three flavonoids: flavone, 7-methoxyflavone and 3',4',5',5,7-pentamethoxyflavone. The two last compounds showed high ability to inhibit the gGAPDH activity. Therefore, the assayed Meliaceae species could be considered as a promising source of lead compounds against Chagas' disease.

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Section: Discussionmentioning

confidence: 99%

Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase enzyme inhibitors

Leite¹,

Ambrozin²,

Castilho³

et al. 2009

Rev. bras. farmacogn.

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“…Os efeitos causados por T. elegans e T. clausseni podem estar associados a um ou mais compostos orgânicos já isolados e identificados em sementes de T. elegans (Garcez et al 1996(Garcez et al , 1997(Garcez et al , 2000 e em caules, folhas e frutos de T. clausseni (Pupo et al 1996(Pupo et al , 1997(Pupo et al , 1998, no entanto, a atividade inseticida destes compostos ainda não foi avaliada.…”

Section: Não Observaram Efeito De Folhas E Caules (Ramos) De Quatro Eunclassified

Bioatividade de extratos aquosos de Trichilia spp. sobre Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) em milho

Bogorni¹,

Vendramim²

2003

Neotrop. Entomol.

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-Spodoptera frugiperda (J.E. Smith) is the most important pest of maize. The high number of chemical applications necessary to its control has lead to some problems as resistance development and environmental contamination. The use of insecticide plants is an alternative to control this pest. The efficacy of aqueous extracts of leaves and twigs from six Trichilia species (T. casaretti, T. catigua, T. clausseni, T. elegans, T. pallens and T. pallida) against S. frugiperda was evaluated in laboratory being compared with the aqueous extract from Azadirachta indica (neem) seeds. Maize leaves immerged in each extract were dried and then given to the first instar larvae. The survival and larval weight were evaluated at the fifth day after treatment application. Concerning the six Trichilia species tested, at least one of their structures (twigs or leaves) affected the insect development. The extracts from leaves of T. pallens caused mortality similar to neem extract; the extracts from twigs of T. pallens, and twigs and leaves of T. pallida, although less efficient, also reduced the S. frugiperda larval weight and survival.KEY WORDS: Insecta, Meliaceae, botanical insecticide RESUMO -Spodoptera frugiperda (J.E. Smith) é atualmente a principal praga da cultura do milho. Seu controle demanda elevado número de aplicações de inseticidas sintéticos, o que agrava o problema de resistência da praga a esses produtos e contaminação do ambiente. Desta forma, o uso de plantas inseticidas apresenta-se como uma alternativa para o controle do inseto. Neste trabalho, foi avaliada a eficiência de extratos aquosos de ramos e folhas de seis espécies de Trichilia (T. casaretti, T. catigua, T. clausseni, T. elegans, T. pallens e T. pallida), em comparação com a do extrato aquoso de sementes de Azadirachta indica (nim) sobre a lagarta S. frugiperda em condições de laboratório. Folhas de milho foram imersas nos extratos e, após evaporado o excesso de água, fornecidas a lagartas de primeiro ínstar, avaliando-se após cinco dias a sobrevivência e peso larval. Para as seis espécies testadas, pelo menos uma das estruturas (ramos ou folhas) afetou o desenvolvimento do inseto. O extrato de folhas de T. pallens causou mortalidade larval semelhante à causada pelo extrato de nim; os extratos de ramos de T. pallens, e de ramos e folhas de T. pallida, embora menos eficientes, também reduziram a sobrevivência e o peso larval de S. frugiperda. PALAVRAS-CHAVE: Insecta, Meliaceae, inseticida botânicoA lagarta-do-cartucho do milho, Spodoptera frugiperda (J.E. Smith), é uma das principais pragas da cultura do milho, podendo seu dano levar à redução de até 34% no rendimento de grãos, dependendo, principalmente, do estádio da cultura em que ocorre o ataque (Valicente & Cruz 1991, Cruz 1995. A utilização de inseticidas sintéticos tem sido o principal método de controle da praga, porém, seu uso indiscriminado e incorreto tem aumentado o número de aplicações e diminuído sua eficiência, principalmente devido ao surgimento de populações de insetos resistent...

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“…yielded a pure limonoid compound TS3 with activity to correct the growth defect of YRG2-⌬F. Limonoids are a group of highly oxidized terpenoids present in several species of the genus Trichilia (50)(51)(52)(53)(54)(55)(56)(57). Several biological activities have been shown for limonoid compounds: insect antifeedant (58-60), inhibition of cell adhesion (61), toxicity to DNA repair deficient yeast (62), and antimicrobial activity (63).…”

Section: Discussionmentioning

confidence: 99%

Drug Development and Conservation of Biodiversity in West and Central Africa: Performance of Neurochemical and Radio Receptor Assays of Plant Extracts Drug Discovery for the Central Nervous System

Efange¹,

Mash²

2004

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) 01-09-2004 REPORT TYPE PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Miami Miami FL 33136 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe thrust of the CNS assay panel was to identify plant extracts that display moderate to high affinity for selected molecular targets. Target selection was based identifying active plant extracts that would be useful for one or more neuropsyschiatric disorders. We completed a screen for 102 samples belonging to 43 plants. 41 showed activity at one or more CNS targets. Phytochemical studies have been initiated on several active extracts. A total of 12 plants samples which have tested positive for antiplasmodial activity were collected in bulk quantities for detailed phytochemical investigations into antimalarial and trypanocidal activity. SUBJECT TERMSCNS targets, drug discovery, phytochemistry

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Limonoids from Trichilia elegans ssp. elegans

Cited by 39 publications

References 25 publications

Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase enzyme inhibitors

Screening of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase enzyme inhibitors

Bioatividade de extratos aquosos de Trichilia spp. sobre Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) em milho

Drug Development and Conservation of Biodiversity in West and Central Africa: Performance of Neurochemical and Radio Receptor Assays of Plant Extracts Drug Discovery for the Central Nervous System

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