Limonoids from the leaves of Soymida febrifuga and their insect antifeedant activities

Yadav, P. Ashok; Suresh, G.; Rao, Ming; Shankaraiah, G.; Rani, Poonam; Babu, K. Suresh

doi:10.1016/j.bmcl.2013.12.077

Cited by 25 publications

(14 citation statements)

References 24 publications

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“…Storage free triterpenes in the form of esters inside cytosolic LDs can minimize the cell toxic effects of their free forms. Triterpenes were demonstrated to have antimicrobial-, antifeedant-, and insecticidal-activities (Osbourn, 1996; Fu et al, 2014; Yadav et al, 2014; Yang and Lin, 2017; Nzogong et al, 2018). Their accumulation during leaf growth in Camellia sinensis could serve as defense mechanism against pathogens and herbivores.…”

Section: Discussionmentioning

confidence: 99%

Terpenoid Esters Are the Major Constituents From Leaf Lipid Droplets of Camellia sinensis

Zhou

Chen

et al. 2019

Front. Plant Sci.

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Lipid droplets (LDs) have been widely found from diverse species and exhibit diverse functions. It remains unexplored what potential roles they played in tea. To address this question, we analyzed the chemical composition and the dynamic changes of cytosolic LDs during leaf growth and diurnal cycle. Using TopFluor cholesterol and Nile Red staining we demonstrated that cytosolic LDs were heterogeneous in tea tree ( Camellia sinensis cv. Tieguanyin ); the size and number of LDs increased with leaf growth. Compositional analysis showed that terpenoid esters and diacylglycerol are the major components of cytosolic LDs. The contents of total sterol esters (SEs) and β-amyrin esters increased with leaf expansion and growth; individual SE also showed diurnal changes. Our data suggest that cytosolic LDs from tea tree leave mainly serve as storage site for free sterols and triterpenoids in the form of esters. Cytosolic LDs were not the major contributors to the aroma quality of made tea.

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Section: Discussionmentioning

confidence: 99%

Terpenoid Esters Are the Major Constituents From Leaf Lipid Droplets of Camellia sinensis

Zhou

Chen

et al. 2019

Front. Plant Sci.

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“…The acetyl group at C12 in Turrapubin A is replaced by Isobutanoyloxy and 2-methylbutanoxy groups in Turrapubin B and C (385 and 386) respectively. Toonayunnanin F (387) is structurally similar to Toonasinenine E but differ at C8 hydroxylation and acetoxyl group at C11 is absent; in addition to this, Toonasinenine G (388) has hydroxyl group at C12. Toonayunnanin I ( 389) is acetylated at C6 with C1, C11 ether linkage when compared to Toonayunnanin F. Limonoids (390)(391)(392)(393) vary at C6 and C12 in acetylation and hydroxylation as compared to compound (389).…”

Section: Vilasininmentioning

confidence: 99%

Chemistry and Biology of Novel Meliaceae Limonoids

Mulani

Nandikol

Thulasiram

2022

Preprint

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Nature has bestowed us with abundant bioactive/drug molecules for various uses in our everyday life. One such group of plant specialized molecules is limonoids, which are structurally characterized as 4,4,8-trimethyl-17-furanyl steroidal skeleton. Limonoids are well known for their various biological activities such as potent anti-feedent, anti-cancer, anti-inflammatory, insecticidal, anti-diabetic, anti-viral, anti-microbial etc. These tetranortriterpenes are highly oxygenated and structurally diversified molecules majorly found in Meliaceae and Rutaceae and less frequently in the Cneoraceae families in the plant kingdom. Many of these plants have been used in traditional medicine from ages. One of the well-known limonoid, azadirachtin A is highly valued and widely popular for its outstanding insecticidal properties. Till date, nearly 2500 limonoids with over 35 unique carbon frameworks have been observed. In recent times, these molecules have dig a great interest among researchers due to their myriad biological properties. With the advancement of analytical techniques, the limonoid research is aced to explore more different molecules from their sources. In our review we cover all the Meliaceous limonoids isolated during July 2010 to Dec 2020. We found over 1502 new limonoids, which are reported from various Meliaceae plants after Jun 2010. We have classified them based on their skeletal structure rearrangements and functional groups into various classes such as protolimonoids, Apoprotolionoid, Azadirone, Vilasinin, Cedrelone, Havanensin, Trichilin, Nimbin, Salannin, Azadirachtin, Nimbolidin, Nimbolinin, Obacunol, Evodulone, Trijugin, Cipadesin, Andirobin, Mexicanolide, Phragmalin, Khayanolide, Preieurianin, Aphanamixoid, Nor Limonoid and N-containing derivatives. Further we have discussed their biological activities in detail.

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“…According to incomplete statistics, more than 55,000 terpenoids have been identified in extant organisms. There are known to have many momentous biological and physiological functions, and are widely used in pharmaceutical, cosmetic, food, beverages, pigments and condiment industries [3][4][5][6]. Such as, some terpenoids are crucial components of cytoderm, membrane structures and electron transfer systems in plants [7].…”

Section: Introductionmentioning

confidence: 99%

The Evolutionary Rate Variation Among Genes of MVA and MEP Pathways in Plant Terpenoid Biosynthesis

Mao

Huang

Hao

et al. 2020

Preprint

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Background: Terpenoids are one of the most important compounds in plants, play an significant biological defense and developmental roles in numerous plant species, and widely used for industrial chemicals. Many previous studies have completed the identification of terpenoid biosynthetic pathway and related genes. However, few studies have focused on the molecular evolution analysis of terpenoid pathway genes in plants. In this study, we researched the evolutionary rate variation pattern of 16 terpenoid pathway genes in 12 species with a broad taxonomic span. Results: We retrieved 14 genes in MVA and MEP pathways and 2 extra genes from 12 species, respectively. The evolutionary parameters dN values and dN/ dS ratios are varied significantly among genes, and the dN/ dS ratios of most genes are varied substantially among lineages. The MVA and MEP pathways genes have different evolutionary rate variation pattern, although no significant difference in dN/ dS ratios between two pathways genes. For MVA pathway, the downstream genes exhibits the greater dN/ dS ratio than upstream genes. For MEP pathway, the three midstream genes evolves more rapidly than other genes, and most of MEP pathway genes were detected the signature of positive selection under random sites models. Moreover, the dN/ dS ratios of MVA and MEP pathways genes are negatively correlated with pathway position and PPI, and coding sequence length, respectively. Conclusions: Taken together, the results indicated that the evolutionary rate variation of MVA pathway genes is mainly attributed to differential selective constraint rather than the positive selection. However, the differential selective constraint relaxation and positive selection collectively shaped the evolutionary rate heterogeneity of MEP pathway genes.

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Limonoids from the leaves of Soymida febrifuga and their insect antifeedant activities

Cited by 25 publications

References 24 publications

Terpenoid Esters Are the Major Constituents From Leaf Lipid Droplets of Camellia sinensis

Terpenoid Esters Are the Major Constituents From Leaf Lipid Droplets of Camellia sinensis

Chemistry and Biology of Novel Meliaceae Limonoids

The Evolutionary Rate Variation Among Genes of MVA and MEP Pathways in Plant Terpenoid Biosynthesis

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