Limits of Operation for the Integration of Water Removal by Membranes and Crystallization of <scp>l</scp>-Phenylalanine

Cuellar, Maria C.; Herreilers, Simone N.; Straathof, Adrie J. J.; Heijnen, Joseph J.; Wielen, Luuk A.M. van der

doi:10.1021/ie8012659

Cited by 20 publications

(21 citation statements)

References 18 publications

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“…Figure 1.4 provides a schematic representation of a RO-assisted crystallization unit. 39 Because the flow to from the membrane is very large compared to the feed flow to the crystallizer, the feed vessel and the RO membrane unit are considered as a single well-mixed unit (dashed box in the figure).…”

Section: Pressure-driven Membrane Processesmentioning

confidence: 99%

Overview of Membrane-Assisted Crystallization Operations

Drioli¹,

Profio²,

Curcio³

2015

Membrane-Assisted Crystallization Technology

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The interest in combining membrane operations and solution crystallization is motivated by the aim to develop more efficient crystallization processes. Membranes, with their intrinsic characteristics of efficiency and operational simplicity, high selectivity, and permeability for the transport of specific components, compatibility between different membrane operations in integrated systems, low energetic requirement, good stability under operating conditions and environmental compatibility, easy control and scale-up, and large operational flexibility, represent a technology that well satisfies the concept of the rationalization of chemical productions, leading to significant innovation in both processes and products. Accordingly, membrane technology provides significant improvements in crystallization. This approach has been put in practice in a number of membrane-assisted crystallization (MAC) configurations. The main features of MAC are:

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Section: Pressure-driven Membrane Processesmentioning

confidence: 99%

Overview of Membrane-Assisted Crystallization Operations

Drioli¹,

Profio²,

Curcio³

2015

Membrane-Assisted Crystallization Technology

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show abstract

“…[28][29][30][31][32][33][34] High-quality protein crystals, suitable for X-ray diffraction analysis at atomic resolution, were grown by using this approach. 31,35,36 In more recent years, other MAC operations based on nanofiltration (NF) 37 and, mainly, on RO [38][39][40][41][42][43] stages, to concentrate a stream prior to batch cooling crystallization, have been studied.…”

Section: Membranes and Crystallization Operationsmentioning

confidence: 99%

“…In more recent years, other MAC operations based on nanofiltration (NF) and, mainly, on RO – stages, to concentrate a stream prior to batch cooling crystallization, have been studied.…”

Section: Membranes and Crystallization Operationsmentioning

confidence: 99%

Supersaturation Control and Heterogeneous Nucleation in Membrane Crystallizers: Facts and Perspectives

Profio

Curcio

Drioli

2010

Ind. Eng. Chem. Res.

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The interest to combine membrane operations and solution crystallization has grown in the past several years. This approach has been put into practice in several forms of membrane-assisted crystallization (MAC) processes, among which is membrane crystallization (MCr) technology. The main features of MCr are (1) the use of membranes as precision devices to control the composition of the crystallizing solution, by opposing a well-defined and tunable resistance to mass flow occurring in the vapor phase; (2) the action of the porous surface of the membrane as a suitable support to activate heterogeneous nucleation mechanisms; (3) the possibility to induce nucleation and crystal growth in separate sites, thus reducing the risk of membrane fouling even when the same membrane supports heterogeneous nucleation. Thanks to these fundamental options, combined together in a unique apparatus, advantages like (i) improved control of the supersaturation degree and the rate of its generation; (ii) the possibility for the crystallization to be initiated at low supersaturation levels; (iii) the enhancement of the crystallization kinetics; and (iv) improved overall process efficiency can be achieved, even for large and complex molecules like proteins. The most interesting developments and the more exciting perspectives for this novel technology have been reviewed in this paper.

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“…In the present work, L-Phenylalanine (L-Phe, C38H72N2O12) was chosen as a model system which exits in an anhydrous form and as a monohydrate form [11]. L-Phe is one of the nine essential amino acids and an important intermediate in the synthesis of many biological and chemical substances [12][13][14], widely used in the pharmaceutical, chemical and food industries [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

The Methods to Crystallize Anhydrous L-Phenylalanine from Methanol-Water Solution

Cao

Ben³

et al. 2020

Crystals

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In this paper, the transformation water activity of L-Phenylalanine (L-Phe) in a methanol-water solution at a different temperature was measured by the ternary diagram. The influence of water activity on the transformation temperature and on the transformation rate was investigated. The solubility of the metastable form of different water activities was estimated based on the thermodynamic equilibrium and the results showed that the anhydrous L-Phe can be synthesized at room temperature by decreasing water activity, the transformation rate from monohydrate to anhydrate was enhanced with the increase of water activity. The predicted solubility value is in good agreement with the experimentally obtained. Meanwhile, tailor-made additives were applied into the system as to investigate the transformation behavior of L-Phe. Their mechanism was proposed based on the Langmuir model fitting. The result manifested that the addition of L-Trp/L-His amino acid in the L-Phe solution decelerated the transformation rate. When the concentration of L-Trp amino acid reached 0.7 × 10−4 mol/mL, the transformation behavior of L-Phe can be fully impeded, and the transformation behavior can be partially inhibited with the addition of L-Trp at 313.15 K or with the addition of L-His at 283.15 K/313.15 K.

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Limits of Operation for the Integration of Water Removal by Membranes and Crystallization of l-Phenylalanine

Cited by 20 publications

References 18 publications

Overview of Membrane-Assisted Crystallization Operations

Overview of Membrane-Assisted Crystallization Operations

Supersaturation Control and Heterogeneous Nucleation in Membrane Crystallizers: Facts and Perspectives

The Methods to Crystallize Anhydrous L-Phenylalanine from Methanol-Water Solution

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