Limited Tolerance of Ofloxacin and Pyrazinamide Prophylaxis in Health Care Workers Following Exposure to Rifampinisoniazid- Streptomycin-Ethambutol-Resistant Tuberculosis

Spread of Strain W, a Highly Drug‐Resistant Strain ofMycobacterium tuberculosis, Across the United States

“…Two studies demonstrated high rates of intolerance (including elevated aminotransferase levels) to preventive therapy with ofloxacin and pyrazinamide [12,13]. In both studies, adverse effects due to alternative preventive therapy caused the regimen to be discontinued within the first 6 months in the majority of the participants.…”

“…In both studies, adverse effects due to alternative preventive therapy caused the regimen to be discontinued within the first 6 months in the majority of the participants. Also, one study that involved HCWs infected with MDR tuberculosis reported a very low acceptance rate (56%) of the alternative preventive therapy [13]. The CDC has been collecting information from multiple sources about the rates of completion of therapy associated with alternative preventive therapy [14,15].…”

Reemergence of Established Pathogens in the 21st Century

“…Fourteen of sixteen patients (87.5%) had reported some adverse effect, compared with 20.6% of another group on isoniazid treatment (Horn et al, 1995). In a study of health care workers exposed to MDRTB (manifesting tuberculin skin test conversions), only 12.5% completed therapy with pyrazinamide and ofloxacin, and 43.8% experienced arthralgias.…”