Limited Contribution of Circulating Cells to the Development and Maintenance of Nonhematopoietic Bovine Tissues

Niku, Mikael; Ilmonen, Lotta; Pessa‐Morikawa, Tiina; Iivanainen, Antti

doi:10.1634/stemcells.22-1-12

Cited by 20 publications

(14 citation statements)

References 73 publications

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“…We observed changes in the expression of genes which regulate the renewal of hematopoietic stem cells (HSCs), e.g., HOXB4, MLL5, TAC1, and MYB. HSCs are particularly important in the context of their penetration into the mammary gland and their potential effect on glandular development (Niku et al 2004). HOXB4 (showing up-regulated expression in this study) activates Myc transcription factor, which also showed a higher expression.…”

Section: Discussionmentioning

confidence: 99%

Comparison of stem/progenitor cell number and transcriptomic profile in the mammary tissue of dairy and beef breed heifers

et al. 2014

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Bovine mammary stem cells (MaSC) are a source of ductal and lobulo-alveolar tissue during the development of the mammary gland and its remodeling in repeating lactation cycles. We hypothesize that the number of MaSC, their molecular properties, and interactions with their niche may be essential in order to determine the mammogenic potential in heifers. To verify this hypothesis, we compared the number of MaSC and the transcriptomic profile in the mammary tissue of 20-month-old, non-pregnant dairy (Holstein-Friesian, HF) and beef (Limousin, LM) heifers. For the identification and quantification of putative stem/progenitor cells in mammary tissue sections, scanning cytometry was used with a combination of MaSC molecular markers: stem cell antigen-1 (Sca-1) and fibronectin type III domain containing 3B (FNDC3B) protein. Cytometric analysis revealed a significantly higher number of Sca-1posFNDC3Bpos cells in HF (2.94 ± 0.35 %) than in LM (1.72 ± 0.20 %) heifers. In HF heifers, a higher expression of intramammary hormones, growth factors, cytokines, chemokines, and transcription regulators was observed. The model of mammary microenvironment favorable for MaSC was associated with the regulation of genes involved in MaSC maintenance, self-renewal, proliferation, migration, differentiation, mammary tissue remodeling, angiogenesis, regulation of adipocyte differentiation, lipid metabolism, and steroid and insulin signaling. In conclusion, the mammogenic potential in postpubertal dairy heifers is facilitated by a higher number of MaSC and up-regulation of mammary auto- and paracrine factors representing the MaSC niche.

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Section: Discussionmentioning

confidence: 99%

Comparison of stem/progenitor cell number and transcriptomic profile in the mammary tissue of dairy and beef breed heifers

et al. 2014

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“…To date, Friedenstein's procedure is considered a standard protocol to isolate bone marrow (BM) MSCs (4,14,15). Isolation and phenotypic characterization of MSCs have been demonstrated in several vertebrate species, including human (6,12,16), murine (4,5,15), lapine (17), canine (18), ovine (19), avian (20), porcine (21), equine (22), and bovine (23). However, MSC colonies isolated by adherence to the plastic culture plate are heterogeneous, likely containing osteoblasts and/or osteoprogenitor cells, fat cells, fibroblasts, reticular cells, macrophages, endothelial cells, and a fraction of blood cells and hematopoietic stem cells (24,25).…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cells: Isolation and Therapeutics

Alhadlaq

Mao

2004

Stem Cells and Development

484

200

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Mesenchymal stem cells (MSCs) are progenitors of all connective tissue cells. In adults of multiple vertebrate species, MSCs have been isolated from bone marrow (BM) and other tissues, expanded in culture, and differentiated into several tissue-forming cells such as bone, cartilage, fat, muscle, tendon, liver, kidney, heart, and even brain cells. Recent advances in the practical end of application of MSCs toward regeneration of a human-shaped articular condyle of the synovial joint is one example of their functionality and versatility. The present review not only outlines several approaches relevant to the isolation and therapeutic use of MSCs, but also presents several examples of phenotypic and functional characterization of isolated MSCs and their progeny.

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“…We have always assumed that these are analogous in different taxa, but perhaps this is an error to make such an assumption. Niku et al ( 2004 ) showed that among the hematopoietic precursors are some remarkably multipotent cells that are irregularly distributed throughout the body and that become especially prominent in granulation tissue. From the same laboratory comes evidence of the variable percentage of B-and T-cells.…”

Section: Chimerism Mosaicismmentioning

confidence: 99%