Limitations in the use of rifampicin-gelatin grafts against virulent organisms

Koshiko, Susumu; Sasajima, Tadahiro; Muraki, Senichi; Azuma, Nobuyoshi; Yamazaki, Kohsuke; Chiba, Kaoru; Tachibana, Mineji; Inaba, Masashi

doi:10.1067/mva.2002.121850

Cited by 66 publications

(42 citation statements)

References 22 publications

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“…However, MRSA has been reported to demonstrate no bacterial antibiotic susceptibility to 0.1% rifampicin-gelatin grafts according to the fi ndings of an in vitro susceptibility test. 30 Other studies in the literature confi rmed the effi cacy of gelatin-sealed grafts that were prebonded with 1.3% rifampin and 1.7% tobramycin in resisting infection with S. aureus in a dog model (Table 4). 31,32 However, silver grafts have been clearly shown to have better in vitro activity against a broad spectrum of bacteria.…”

Section: Discussionmentioning

confidence: 93%

Primary infected abdominal aortic aneurysm: Surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period

et al. 2011

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Section: Discussionmentioning

confidence: 93%

Primary infected abdominal aortic aneurysm: Surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period

et al. 2011

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“…For in situ Dacron graft replacement, patients have a 30-day operative mortality of 17 % [ 29 ]. A 30-day mortality for all cryopreserved arterial grafts is 7.5 % [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical and Endovascular Complications: Infection and Hemorrhage

Davies

2014

Essentials of Vascular Surgery for the General Surgeon

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In all cases of hemorrhage, the Advanced Trauma Life Support (ATLS) algorithm should be followed, with prompt recognition, rapid resuscitation, and immediate decision making and action [ 1 ]. Retroperitoneal Hemorrhage EtiologyRetroperitoneal hematoma (RPH) describes bleeding into the potential space between the peritoneum and the musculoskeletal elements of the back. Several conditions can cause RPH including ruptured aortic aneurysm, traumatic vascular injury, retroperitoneal neoplasms, and coagulopathy. RPH occurs most frequently as a complication of percutaneous femoral artery puncture for interventional procedures. The reported incidence of RPH after cardiac catheterization is 0.15 % for diagnostic procedures, 0.8 % for balloon angioplasty, and 3 % for coronary stents. Three dichotomous variables were identifi ed as independent predictors of RPH: female gender (odds ratio [OR] 5.4), body surface area (BSA) less than 1.73 m 2 (OR 7.1), and high femoral artery puncture site (OR 5.3) [ 2 ]. Twenty-fi ve percent of retroperitoneal bleeds were remote from the femoral artery puncture site, with the majority of these being contralateral to the side of the puncture. PresentationThe diagnosis of retroperitoneal hematoma requires clinical acumen, and an awareness of the scenarios in which this complication is likely to occur. Patients with signifi cant groin, fl ank, abdominal, or back pain or hemodynamic instability following an interventional procedure should be evaluated for a retroperitoneal hematoma. The nonspecifi c symptoms associated with RPH often delay the diagnosis. Approximately 23-54 % of retroperitoneal hematoma patients have documented clinical evidence of femoral neuropathy caused by compression of the femoral nerve [ 3 ]. Seventy-fi ve percent of cases presented within the fi rst 3 h after conclusion of the procedure, with a rapid decline in frequency after this time period [ 4 ]. Spontaneous hemorrhage usually occurs in patients receiving anticoagulation. Idiopathic retroperitoneal hematoma may present symptomatically in the form of acute abdominal pain, nausea, and anorexia. Upon physical examination, the patient may have a tender abdomen and hypovolemic shock. ImagingContrast-enhanced computed tomography (CT) scan is the imaging modality of choice to identify and categorize a retroperitoneal hemorrhage (Fig. 23.1 ). TreatmentAlthough a widely accepted consensus on the management of patients with RPH does not exist, a reasonable treatment algorithm is shown in Fig. 23.2 . Conservative TherapyHemodynamically stable patients with RPH can be managed with fl uid resuscitation, correction of coagulopathy, and blood transfusion. Non-interventional therapy mandates close observation for the development of abdominal compartment syndrome (ACS) which can be fatal if it is not promptly recognized and treated. ACS is defi ned as sustained intra-abdominal pressure greater than 20 mmHg with end-organ dysfunction manifested as respiratory insuffi ciency, oliguria, and decreased venous return resulting in severe hy...

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“…Its copolymers, lactides and glycolide are getting increasing attention because of their controllable biodegradation rates in the desirable ranges (slower) and also more suitable and tailor-made mechanical properties (more flexible and softer) for some applications such as long-term drug delivery and tissue repair and regeneration [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of electrospun polycaprolactone/polyethylene oxide/vancomycin nanofiber mat for prevention of periprosthetic infection and biofilm formation

Jang

Cho

Jang³

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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Limitations in the use of rifampicin-gelatin grafts against virulent organisms

Abstract: These results suggested that rifampicin-gelatin grafts are clearly valid for S epidermidis infection, whereas no efficacy was recognized against either MRSA or E coli graft infection because of early development of high minimal inhibitory concentration MRSA strains or poor susceptibility.

Cited by 66 publications

References 22 publications

Primary infected abdominal aortic aneurysm: Surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period

Primary infected abdominal aortic aneurysm: Surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period

Surgical and Endovascular Complications: Infection and Hemorrhage

Antibacterial effect of electrospun polycaprolactone/polyethylene oxide/vancomycin nanofiber mat for prevention of periprosthetic infection and biofilm formation

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