Limitations and usefulness of biopsy techniques for the diagnosis of metastatic bone and soft tissue tumors

Hashimoto, Kazuhiko; Nishimura, Shunji; Ito, Tomohiko; Oka, Naohiro; Akagi, Masao

doi:10.1016/j.amsu.2021.102581

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…In the study by Cheng and Xin, 4,7 multivariate Cox regression also suggested that TNM stage and sex were independent prognostic factors for advanced esophageal cancer patients 4,7 . ECOG performance status is a widely used method of assessing the functional status of cancer patients in many studies 22–24 . In addition, we found that the mGPS, based on serum CRP and albumin, is a cost‐effective, accessible tool capable of prognosticating in this cohort of advanced esophageal SCC patients.…”

Section: Discussionmentioning

confidence: 64%

“…4,7 ECOG performance status is a widely used method of assessing the functional status of cancer patients in many studies. [22][23][24] In addition, we found that the mGPS, based on serum CRP and albumin, is a cost-effective, accessible tool capable of prognosticating in this cohort of advanced esophageal SCC patients. Recent studies have revealed that mGPS is inversely related to prognosis in a variety of cancers, such as urothelial carcinoma, colorectal cancer, gastric cancer, and lung cancer, 11,12,15,25 but few studies regarding mGPS in esophageal cancer are available, especially SCC.…”

Section: Discussionmentioning

confidence: 76%

“…26,27 Albumin reflects the malnutrition status of the body, triggers the malignant transformation, and promotes the progression of tumors. 24 The multivariate analysis suggested that sex, M stage, and ECOG score showed good levels of prognostic stratification between low-risk and high-risk patients (all p < 0.05). However, the mGPS for OS prediction demonstrated a better performance than that of sex and ECOG score.…”

Section: Discussionmentioning

confidence: 91%

“…Serum CRP is an acute reactive protein synthesized by liver cells or cancer cells that can produce an attractive environment for cancer cell proliferation, promote angiogenesis, induce DNA damage, and favor neoplastic metastasis, revealing the level of inflammation in the body. 26,27 Albumin reflects the malnutrition status of the body, triggers the malignant transformation, and promotes the progression of tumors 24 …”

Section: Discussionmentioning

confidence: 99%

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Modified Glasgow prognostic score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: A propensity score‐matched analysis

Cui

Deng

et al. 2022

Thoracic Cancer

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The aim of this study is to evaluate the prognostic value of the modified Glasgow prognostic score (mGPS) in advanced esophageal squamous cell carcinoma (SCC) patients. Methods: The study enrolled 311 patients with advanced esophageal SCC from January 2012 to December 2018. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model in advanced esophageal SCC patients. The Kaplan-Meier method was used to evaluate the ability of the mGPS for survival rates. Propensity score-matched (PSM) analysis was carried out to balance imbalanced variables. Results: The Cox proportional hazards analysis showed that factors including M stage, ECOG, mGPS group, and sex were identified as independent predictors. The mGPS presented a good level of overall survival (OS) prediction with a risk-adopted classification for advanced esophageal SCC patients. The survival rates in advanced esophageal SCC patients with mGPS 0, 1, and 2 were 18.8%, 8.4%, and 4.2%, respectively (p < 0.001). Moreover, before and after PSM, the mGPS was associated with 3-year survival rates of advanced esophageal SCC patients in the Kaplan-Meier survival analysis. In addition, the mGPS for OS prediction demonstrated better performance than sex and ECOG score. The area under curve (AUC) of the mGPS combined with M stage for the prognosis of advanced esophageal SCC was 0.677 (0.592-0.763). Conclusion:The mGPS is a cost-effective, accessible tool capable of prognosticating in this cohort. It could be a useful surveillance system of prognosis in advanced esophageal SCC patients.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Modified Glasgow prognostic score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: A propensity score‐matched analysis

Cui

Deng

et al. 2022

Thoracic Cancer

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“…In the prostate, PGK1 and G6PD were determined as optimal glucose metabolic markers for CTCs [139]. Further, a recent study published by Hashimoto K. and colleagues [144] provides strong evidence that disease-specific patterns detected in biopsies are generally useful for diagnosing bone and soft tissue metastases, for identifying their primary site that allows for targeted treatments and may lead to improved individual outcomes [144].…”

Section: Liquid Biopsy Biomarker Panels For Pca Prediction Prognosis and Patient Stratification: Status Quo And Outlookmentioning

confidence: 99%

Systemic Effects Reflected in Specific Biomarker Patterns Are Instrumental for the Paradigm Change in Prostate Cancer Management: A Strategic Paper

Golubnitschaja

Kubatka

Mazuráková

et al. 2022

Cancers

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Prostate cancer (PCa) is reported as the most common malignancy and second leading cause of death in America. In Europe, PCa is considered the leading type of tumour in 28 European countries. The costs of treating PCa are currently increasing more rapidly than those of any other cancer. Corresponding economic burden is enormous, due to an overtreatment of slowly developing disease on one hand and underestimation/therapy resistance of particularly aggressive PCa subtypes on the other hand. The incidence of metastatic PCa is rapidly increasing that is particularly characteristic for young adults. PCa is a systemic multi-factorial disease resulting from an imbalanced interplay between risks and protective factors. Sub-optimal behavioural patterns, abnormal stress reactions, imbalanced antioxidant defence, systemic ischemia and inflammation, mitochondriopathies, aberrant metabolic pathways, gene methylation and damage to DNA, amongst others, are synergistically involved in pathomechanisms of PCa development and progression. To this end, PCa-relevant systemic effects are reflected in liquid biopsies such as blood patterns which are instrumental for predictive diagnostics, targeted prevention and personalisation of medical services (PPPM / 3P medicine) as a new paradigm in the overall PCa management. This strategic review article highlights systemic effects in prostate cancer development and progression, demonstrates evident challenges in PCa management and provides expert recommendations in the framework of 3P medicine.

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Phage antibodies against heat shock proteins as tools for in vitro cancer diagnosis

Староверов

Козлов

Бровко

et al. 2022

Biosensors and Bioelectronics: X

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Limitations and usefulness of biopsy techniques for the diagnosis of metastatic bone and soft tissue tumors

Cited by 10 publications

References 19 publications

Modified Glasgow prognostic score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: A propensity score‐matched analysis

Modified Glasgow prognostic score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: A propensity score‐matched analysis

Systemic Effects Reflected in Specific Biomarker Patterns Are Instrumental for the Paradigm Change in Prostate Cancer Management: A Strategic Paper

Phage antibodies against heat shock proteins as tools for in vitro cancer diagnosis

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