Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea

Kang, Eun Seok; Yun, Yong Seok; Park, Seok Won; Kim, Hyeung Jin; Ahn, Chul Woo; Song, Young Duk; Soo, Bong; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul

doi:10.1016/j.metabol.2004.08.014

Cited by 131 publications

(120 citation statements)

References 22 publications

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“…In contrast to the previously published data, which were only partly subjected to multivariable regression analysis, the associations shown in multivariable models presented herein were adjusted for cardiovascular risk factors and the components of the metabolic syndrome. On the other hand, clamp studies reflect insulin sensitivity more accurately than the HOMA-IR used in the present study [15,16]. In addition, it seems possible that glucose-lowering agents in our cohort of men with type 2 diabetes might have obscured the association between the HOMA-IR and RBP4 levels.…”

Section: Discussionmentioning

confidence: 75%

Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease

et al. 2007

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Aims/hypothesis Retinol-binding protein 4 (RBP4) has recently been reported to be associated with insulin resistance and the metabolic syndrome. This study tested the hypothesis that RBP4 is a marker of insulin resistance and the metabolic syndrome in patients with type 2 diabetes or coronary artery disease (CAD) or in non-diabetic control subjects without CAD. Methods Serum RBP4 was measured in 365 men (126 with type 2 diabetes, 143 with CAD and 96 control subjects) and correlated with the homeostasis model assessment of insulin resistance index (HOMA-IR), components of the metabolic syndrome and lipoprotein metabolism. RBP4 was detected by ELISA and validated by quantitative Western blotting. Results RBP4 concentrations detected by ELISA were shown to be strongly associated with the results gained in quantitative Western blots. There were no associations of RBP4 with HOMA-IR or HbA 1c in any of the groups studied. In patients with type 2 diabetes there were significant positive correlations of RBP4 with total cholesterol, LDL-cholesterol, VLDL-cholesterol, plasma triacylglycerol and hepatic lipase activity. In patients with CAD, there were significant associations of RBP4 with VLDLcholesterol, plasma triacylglycerol and hepatic lipase activity, while non-diabetic control subjects without CAD showed positive correlations of RBP4 with VLDLcholesterol and plasma triacylglycerol. Conclusions/interpretation RBP4 does not seem to be a valuable marker for identification of the metabolic syndrome or insulin resistance in male patients with type 2 diabetes or CAD. Independent associations of RBP4 with pro-atherogenic lipoproteins and enzymes of lipoprotein metabolism indicate a possible role of RBP4 in lipid metabolism.

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Section: Discussionmentioning

confidence: 75%

Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease

et al. 2007

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“…Many of previous studies used HOMA-IR as a marker of insulin resistance because it is simple and easily calculated from fasting plasma glucose and insulin concentrations. However, there are also limitations of using HOMA-IR as a marker of insulin resistance particularly in patients with significant hyperglycemia [27][28][29]. In our previous study [29], we found that the correlation between HOMA-IR and euglycemic hyperinsulinemic clamp was relatively poor in subjects with lower BMI, poor beta cell function, and higher fasting plasma glucose concentrations such as lean type 2 diabetic patients.…”

Section: Discussionmentioning

confidence: 93%

“…However, there are also limitations of using HOMA-IR as a marker of insulin resistance particularly in patients with significant hyperglycemia [27][28][29]. In our previous study [29], we found that the correlation between HOMA-IR and euglycemic hyperinsulinemic clamp was relatively poor in subjects with lower BMI, poor beta cell function, and higher fasting plasma glucose concentrations such as lean type 2 diabetic patients. In fact, such characteristics are very common in patients with type 2 diabetes in Korea as well as in many other Asian countries [30].…”

Section: Discussionmentioning

confidence: 93%

Insulin resistance and carotid atherosclerosis in patients with type 2 diabetes

Park¹,

Kim²,

Cho³

et al. 2009

Atherosclerosis

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“…É fundamental ainda destacar que a hemólise das amostras sanguíneas deve ser evitada, uma vez que, quando ela ocorre, há liberação de conteúdo eritrocitá-rio para o soro, resultando liberação de enzimas proteolíticas, que podem degradar hormônios peptídicos (33). Estudo realizado in vitro identificou degradação da insulina em até 25%, podendo levar à subestimação das dosagens (34).…”

Section: Histórico E Bases Fisiológicasunclassified

Análise crítica do uso dos índices do Homeostasis Model Assessment (HOMA) na avaliação da resistência à insulina e capacidade funcional das células-beta pancreáticas

Vasques

Rosado

Alfenas

et al. 2008

Arq Bras Endocrinol Metab

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RESUMOA disfunção das células-e a resistência insulínica são anormalidades metabólicas inter-relacionadas na etiologia do diabetes tipo 2. Em diversos países, tem sido observado o aumento da prevalência de obesidade e diabetes em associação com a presença da resistência insulínica. Nesse contexto, é útil a mensuração da resistência insulínica e da capacidade funcional das células-nos indivíduos. Os índices Homeostasis Model Assessment (HOMA) têm sido amplamente utilizados, representando uma das alternativas para avaliação desses parâmetros, principalmente por figurarem um método rápido, de fácil aplicação e de menor custo. Esta revisão discute sobre a origem e a evolução dos índices HOMA, bem como as particularidades do método, abordando aspectos relacionados à sua validação e aos pontos de corte existentes para sua interpretação. Beta-cell dysfunction and insulin resistance are interrelated metabolic abnormalities in the aetiology of Type 2 Diabetes. In several countries, increases in the prevalence of obesity and diabetes have been observed in association with the presence of insulin resistance. In this context, measurement of insulin resistance and beta-cell function is useful. The HOMA indexes (Homeostasis Model Assessment) have been widely used, representing an alternative for the evaluation of these parameters, particularly as a fast, easy and cheap method. This review discusses the origin and evolution of the HOMA index, as well as details of the method, analyzing features related to its validation and the cutoff limits for its interpretation. INTRODUÇÃOA MANUTENÇÃO DA GLICEMIA NORMAL DEPENDE principalmente da capacidade funcional das células-pancreáticas (BcC) em secretar insulina e da sensibilidade tecidual à ação da insulina (SI) (1). A disfunção das células-e a resistência insulínica (RI) são anormalidades metabólicas inter-relacionadas na etiologia do diabetes melito do tipo 2 (DM2) (1,2). A RI caracteriza-se por falhas das células-alvo em responder aos níveis normais de insulina circulantes, revisão ANA CAROLINA J. VASQUES

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Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea

Cited by 131 publications

References 22 publications

Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease

Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease

Insulin resistance and carotid atherosclerosis in patients with type 2 diabetes

Análise crítica do uso dos índices do Homeostasis Model Assessment (HOMA) na avaliação da resistência à insulina e capacidade funcional das células-beta pancreáticas

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