Lime powder regimen supplement alleviates urinary metabolic abnormalities in urolithiasis patients

Ungjaroenwathana, Wattanachai; Chiramongkolsiri, Thanida; Dissayabutra, Thasinas; Boonla, Chanchai; Prapunwattana, Phisit; Tungsanga, Kriang; Tosukhowong, Piyaratana

doi:10.1111/nep.13493

Cited by 4 publications

(2 citation statements)

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“…Thus, Wattanachai et al . [ 15 ], found that potassium citrate supplementation significantly increased urinary pH and urinary potassium citrate excretion. Taken together, these data suggest that citrate salt can be used as a treatment option in patients with urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic abnormalities in patients with urolithiasis in Kinshasa, the Democratic Republic of Congo

Diangienda¹,

Moningo²,

Sumaili³

et al. 2021

Pan Afr Med J

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Introduction metabolic abnormalities are key factors in urolithiasis patients because they can be modified to prevent the risk of urinary stones. The objectives of this study were to estimate the frequency of metabolic abnormalities in the urine of patients with urolithiasis and to determine their possible link with the chemical composition of stones. Methods we conducted a cross-sectional study evaluating 73 patients referred for urolithiasis in 8 clinics in Kinshasa, between January 2017 and September 2019. Twenty four-hour or early morning urine were collected and analyzed in the Tenon Hospital in Paris. Parameters analyzed included pH, specific gravity, creatinine, uric acid, calcium, phosphate, oxalate, citrate and magnesium. Chi square test or chi-square likelihood-ratio and student's t test were used as statistical tests. Results overall, 89% (n=65) of patients with lithiasis had metabolic abnormalities. Mean (SD) age of patients was 47.0 (14.2) years with male to female ratio of 1.6: 1. The mean (SD) 24-hour diuresis was 1836.4 (1216.9) ml; the mean (SD) urine density was 1.018 (0.007); and the mean (SD) pH was 6.1(0.8). Hypocitraturia was the most frequently observed metabolic abnormality and was found in 76.7% patients. Other significant metabolic abnormalities were low magnesuria (35.6%), hyperoxaluria (11%), and low sulphaturia (74%). Whewellite (73.5%) was the main chemical component. The mean pH was higher in patients with carbapatite and struvite stones (p=0.031). Conclusion this study suggests that inadequate diuresis and hypocitraturia were important lithogenic factors. The population should be encouraged to increase water intake to limit the frequency of urine super saturation with crystals.

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Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic abnormalities in patients with urolithiasis in Kinshasa, the Democratic Republic of Congo

Diangienda¹,

Moningo²,

Sumaili³

et al. 2021

Pan Afr Med J

View full text Add to dashboard Cite

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“…In addition, lime powder inhibits COM crystal growth and prevents reactive oxygen species overproduction in COM crystal–induced tubular cell injury [ 106 ]. Clinical trial in healthy volunteers has revealed that lime powder enhances urinary citrate excretion, increases urine pH, and decreases urinary CaOx supersaturation [ 107 ]. Interestingly, there is no toxic effect of lime powder observed in in vitro cell culture, in vivo mice model, and healthy individuals, suggesting that lime powder should be safe for daily consumption [ 106 ].…”

Section: Strategies To Prevent Ksdmentioning

confidence: 99%