Limbic Encephalitis in Association with Systemic Lupus Erythematosus

Sugi, Suzuna; Kaieda, Shinjiro; Irie, Kohji; Ida, Hiroaki

doi:10.2169/internalmedicine.1009-18

Cited by 2 publications

(6 citation statements)

References 2 publications

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“…The authors observed a spectrum of neurological and psychiatric manifestations such as changes in consciousness, behavioral disturbances, seizures, disorientation, hallucinations, and movement disorders that correspond with the results of EEG and MRI (Angst et al, 2015;Asmaa et al, 2022;Kano et al, 2009;Kelley et al, 2018;Li et al, 2022;Manorenj and Shaik, 2021;Muñoz et al, 2017;Raventhiranathan et al, 2022;Selcuk et al, 2011;Stubgen et al, 1998;Sugi et al, 2018;Tsuchiya et al, 2021;Yamaguchi et al, 2012;Zhang et al, 2021). These neurological deficits encompass a variety of symptoms, including cognitive impairments such as attention deficits, memory deficits, and aphasia, movement disorders such as dystonia, dyskinesia, gait changes, seizures, pseudobulbar affect, delusions, and auditory and visual hallucinations.…”

Section: Neurological and Psychiatric Manifestationsmentioning

confidence: 79%

“…These neurological deficits encompass a variety of symptoms, including cognitive impairments such as attention deficits, memory deficits, and aphasia, movement disorders such as dystonia, dyskinesia, gait changes, seizures, pseudobulbar affect, delusions, and auditory and visual hallucinations. Mood disturbances were identified in one case (Angst et al, 2015;Asmaa et al, 2022;Kano et al, 2009;Kelley et al, 2018;Li et al, 2022;Manorenj and Shaik, 2021;Muñoz et al, 2017;Raventhiranathan et al, 2022;Selcuk et al, 2011;Stubgen et al, 1998;Sugi et al, 2018;Tsuchiya et al, 2021;Yamaguchi et al, 2012;Zhang et al, 2021). Several cases exhibited prolonged epileptic seizures during the course of the disease, with a few cases experiencing comorbidities.…”

Section: Neurological and Psychiatric Manifestationsmentioning

confidence: 99%

“…Out of ten cases with a history of SLE, six patients developed encephalitis while their SLE was under control with steroid treatment, without significant systemic symptoms. Further examinations revealed abnormalities in serum analysis (positive SLE markers) and MRI findings (Angst et al, 2015;Asmaa et al, 2022;Kelley et al, 2018;Li et al, 2022;Raventhiranathan et al, 2022;Selcuk et al, 2011;Stubgen et al, 1998;Sugi et al, 2018;Tsuchiya et al, 2021;Zhang et al, 2021). In one case, the patient had a prior history of diagnosed SLE and anti-NMDAR encephalitis, with encephalitis manifestations emerging during pregnancy (Zhang et al, 2021).…”

Section: Initial Encephalitis and Sle-related Presentationmentioning

confidence: 99%

“…In most cases, patients had a confirmed history of SLE before experiencing encephalitis symptoms (Angst et al, 2015;Asmaa et al, 2022;Kelley et al, 2018;Li et al, 2022;Raventhiranathan et al, 2022;Selcuk et al, 2011;Stubgen et al, 1998;Sugi et al, 2018;Tsuchiya et al, 2021;Zhang et al, 2021). The time interval between the initial SLE diagnosis and the onset of neurological complications varied from two weeks to 14 years (Angst et al, 2015;Asmaa et al, 2022;Kelley et al, 2018;Li et al, 2022;Selcuk et al, 2011;Stubgen et al, 1998;Zhang et al, 2021).…”

Section: Initial Encephalitis and Sle-related Presentationmentioning

confidence: 99%

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Neurological complexity in systemic lupus erythematosus: insights into autoimmune encephalitis

Liana Halim,

Novia Putri

2023

SMJ IDI Surabaya

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Background: Autoimmune encephalitis (AE) is an inflammatory syndrome characterized by autoantibodies targeting the central nervous system (CNS), leading to a wide range of neurological and psychiatric manifestations. Objective: This systematic review aims to investigate the coexistence of AE and systemic lupus erythematosus (SLE) to shed light on potential underlying mechanisms. Materials and Methods: Following PRISMA guidelines, a comprehensive search was conducted using Boolean logic in research databases i.e., PubMed, ProQuest, ScienceDirect, and Web of Science to identify relevant studies on AE, SLE, and their potential correlation. After the initial screening, exclusion, and quality assessment using the Joanna Briggs Institute Critical Appraisal Checklist, 14 studies were included for analysis. Among 18 patients, 88.9% were female whose an average age was 31.9 ± 12.7 years. Clinical presentations were varied, including cognitive impairment (66.67%), seizures (61.1%), altered mental status (50%), and movement disorders. Neuroimaging and neurophysiological findings consistently aligned with encephalitis, with MRI abnormalities observed in 94.4% of cases. Various autoantibodies were identified, including anti-NMDAR, anti-AMPA-R2, and anti-GluR antibodies. Conclusion: The identification of neuronal antibodies is crucial, particularly in scenarios involving both neuropsychiatric SLE (NPSLE) and encephalitis. This investigation aims to reveal etiological insights. The ongoing debate revolves around whether SLE-related encephalitis is associated with NPSLE through SLE antibodies or involves distinct antibodies. Further clinical research is essential to clarify the pathogenic role of autoantibody in SLE-linked AE.

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Section: Neurological and Psychiatric Manifestationsmentioning

confidence: 79%

Section: Neurological and Psychiatric Manifestationsmentioning

confidence: 99%

Section: Initial Encephalitis and Sle-related Presentationmentioning

confidence: 99%

Section: Initial Encephalitis and Sle-related Presentationmentioning

confidence: 99%

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Neurological complexity in systemic lupus erythematosus: insights into autoimmune encephalitis

Liana Halim,

Novia Putri

2023

SMJ IDI Surabaya

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“…Aprašytas encefalitas ligoniui, sergančiam SRV [11,33]. Autoimuninis limbinis encefalitas (ALE), susijęs su SRV, yra reta patologija.…”

Section: Literatūros Apžvalga Ir Diskusijaunclassified

Sisteminės Raudonosios Vilkligės Neurologinės Komplikacijos

Kimševaitė¹

2022

Health Sciences

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Straipsnyje analizuojamos sisteminės raudonosios vilkligės neurologinės komplikacijos. Galvos smegenų kraujotakos sutrikimai, galvos skausmas ir traukuliai yra dažniausios sisteminės raudonosios vilkligės neurologinės komplikacijos. Insultas yra pagrindinė sergančiųjų sistemine raudonąja vilklige sergamumo, mirštamumo ir negalios priežastis. Jaunų asmenų, ypač moterų, išeminis insultas visada turėtų kelti sisteminės raudonosios vilkligės įtarimą. Sisteminę raudonąją vilkligę reikia įtarti ir ligoniams, sergantiems cerebrinių veninių sinusų tromboze. Epilepsiniai priepuoliai dažnesni pirmaisiais sisteminės raudonosios vilkligės metais. Nustatytas didelis sergančiųjų sistemine raudonąja vilklige epilepsijos paplitimas, susijęs su galvos smegenų kraujagyslių ligomis, antifosfolipidiniu sindromu ir psichozėmis. Epilepsinių priepuolių pasikartojimas susijęs su antifosfolipidiniu sindromu. Meningitas, parkinsonizmas ir mielopatija yra retos sisteminės raudonosios vilkligės komplikacijos. Kognityvinė disfunkcija dažna sergant sistemine raudonąja vilklige, ji neigiamai veikia sergančiųjų socialinį funkcionavimą. Migrena yra dažna ligoniams, sergantiems sistemine raudonąja vilklige. Ji nesusijusi su sisteminės raudonosios vilkligės aktyvumu, galvos MRT ir likvoro pokyčiais. Galvos skausmo, sąlygoto sisteminės raudonosios vilkligės, gydymas yra empirinis, pagrįstas klinikine patirtimi. Polineuropatija yra dažniausia sergančiųjų sistemine raudonąja vilklige periferinės nervų sistemos komplikacija. Periferinė neuropatija dažniau pasireiškia ligoniams, sergantiems aktyvia sisteminės raudonosios vilkligės forma. IgG kiekio padidėjimas yra periferinės neuropatijos rizikos veiksnys, sergant sistemine raudonąja vilklige. Guillain-Barré sindromas gali būti pirminė klinikinė sisteminės raudonosios vilkligės apraiška. Kortikosteroidai yra pirmo pasirinkimo vaistai, gydant neurologines uždegimines sisteminės raudonosios vilkligės komplikacijas. Ūminis išeminis insultas, susijęs su sisteminės raudonosios vilkligės vaskulitu, gali būti sėkmingai gydomas intravenine trombolize. Straipsnyje pateikti klinikiniai sisteminės raudonosios vilkligės neurologinių komplikacijų atvejai. Apžvelgta naujausia mokslinė literatūra apie sisteminės raudonosios vilkligės neurologines komplikacijas.

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Limbic Encephalitis in Association with Systemic Lupus Erythematosus

Cited by 2 publications

References 2 publications

Neurological complexity in systemic lupus erythematosus: insights into autoimmune encephalitis

Neurological complexity in systemic lupus erythematosus: insights into autoimmune encephalitis

Sisteminės Raudonosios Vilkligės Neurologinės Komplikacijos

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