Limbic changes identified by imaging in bipolar patients

Paolo, Brambilla; Hatch, John P.; Soares, Jair C.

doi:10.1007/s11920-008-0080-8

Cited by 35 publications

(23 citation statements)

References 59 publications

(69 reference statements)

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“…Nevertheless, the findings of cross-sectional structural MRI studies in children and youths have been controversial. Whereas some studies have identified HCV decreases in young patients with BP [9,10,11], others found no differences in global HCV between children with BP and controls [12,13,14]. Our results suggest that youths with BP may exhibit a later development of the HC structures with continued decreases over time with a longer exposure to the illness.…”

Section: Discussioncontrasting

confidence: 68%

“…Interestingly, although most studies of adults with BP found no decreases in hippocampal volume (HCV) [7,8], the results from studies of children and adolescents have been controversial. Some studies have identified HCV decreases in young patients with BP [9,10,11]. In contrast, some of these studies found no differences in global HCV between children with BP and controls [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

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Decreased Right Hippocampal Volumes and Neuroprogression Markers in Adolescents with Bipolar Disorder

Inal-Emiroglu

Resmi²,

Karabay

et al. 2015

Neuropsychobiology

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Objectives: The aim of the present study was to assess differences and correlations between the hippocampal volumes (HCVs), serum nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) levels in adolescents with bipolar disorder (BP) compared to healthy controls. Methods: Using structural magnetic resonance imaging, we compared HCVs of 30 patients with euthymic BP who were already enrolled in a naturalistic clinical follow-up. For comparison, we enrolled 23 healthy controls between the ages of 13 and 19. The boundaries of the hippocampus were outlined manually. The BDNF and NGF serum levels were measured with the sandwich ELISA. Results: The groups did not differ in the right or left HCVs or in the NGF or BDNF serum levels. However, negative correlations were found between the right HCVs and the duration of the disorder and medication and positive correlations were found between the duration of the medications and the NGF and BDNF levels in the patient group. Additionally, positive correlations were found between the follow-up period and left normalized HCVs in both the BP and lithium-treated groups. Conclusions: The right HCVs may vary with illness duration and the medication used to treat BP; NGF and BDNF levels may be affected by long-term usage. Further research is needed to determine whether these variables and their structural correlates are associated with clinical or functional differences between adolescents with BP and healthy controls.

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Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Decreased Right Hippocampal Volumes and Neuroprogression Markers in Adolescents with Bipolar Disorder

Inal-Emiroglu

Resmi²,

Karabay

et al. 2015

Neuropsychobiology

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“…In keeping with the literature, no evidence of hippocampal volume change was found in the BD patients (see Brambilla et al (2008) for review and Kempton and colleagues and Arnone and colleagues for meta-analyses (Arnone et al 2009;Kempton et al 2008)). The amygdala however showed some evidence of bilateral structural enlargement in BD patients reaching significance for the right.…”

Section: Discussionsupporting

confidence: 58%

“…In contrast to SCZ, recent reviews and meta-analyses of imaging studies in BD find little indication of volumetric change in the hippocampus or amygdala (Arnone et al 2009;Brambilla et al 2008;Frey et al 2007;Kempton et al 2008;Killgore et al 2009;Ng et al 2009), although a few studies highlighting bipolar 'affective psychosis' groups have reported reduced hippocampal volume (Blumberg et al 2003;Strasser et al 2005;Velakoulis et al 1999). Moorhead et al (2007) have shown evidence of accelerated gray matter loss in BD compared to healthy individuals after illness onset and regions affected included the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Structural changes in the hippocampus and amygdala at first episode of psychosis

Watson

Bai

Barrett

et al. 2011

Brain Imaging and Behavior

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Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD). However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.

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“…Abe and colleagues reported significant gray matter volume reduction in MDD patients compared with controls in several brain regions, such as hippocampus (Abe et al 2010). More detailed evidence can be seen in the following reviews (Bora et al 2009;Brambilla et al 2008;Brunet-Gouet and Decety 2006;Konarski et al 2008). Several studies have suggested that Magel2 gene (MAGEL2) might be a susceptibility gene for Pradar-Willie syndrome (Bischof et al 2007;Kanber et al 2009).…”

Section: Introductionmentioning

confidence: 98%

Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population

et al. 2010

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Several investigations have reported that abnormalities in circadian rhythms might be related with the pathophysiology of psychiatric disorders, since many psychiatric patients have insomnia and sleep-awake disturbance. A recent animal study reported that Magel2, which encodes a member of the MAGE/necdin family of proteins, might be associated in the pathophysiology of psychiatric disorders. Magel2 gene knockout mice showed altered concentrations of both dopamine and serotonin in several parts of the brain compared with controls. In addition, the authors of that study detected a bilateral reduction in cortical volume in distinct regions of the Magel2 gene knockout mice brain, including focused regions in the parieto-temporal lobe of the cerebral cortex, the amygdala, the hippocampus, and the nucleus accumbens. These mice were also found to have hypoactivity and abnormalities in circadian rhythms. From this evidence, we considered Magel2 gene (MAGEL2) to be a good candidate gene for the pathophysiology of schizophrenia and mood disorder, and we conducted a case-control study among Japanese (731 schizophrenia patients, 465 MDD patients, 156 BP patients and 758 controls) using three tagging SNPs in MAGEL2 (rs850815, rs8920 and rs4480754), selected using the HapMap database. We did not find any association between MAGEL2 and schizophrenia, BP or MDD in allele/genotype-wise analysis or haplotype-wise analysis. Our results suggest that MAGEL2 may not play a role in the pathophysiology of schizophrenia and mood disorders in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small and our study analyzed only three SNPs in MAGEL2.

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Limbic changes identified by imaging in bipolar patients

Cited by 35 publications

References 59 publications

Decreased Right Hippocampal Volumes and Neuroprogression Markers in Adolescents with Bipolar Disorder

Decreased Right Hippocampal Volumes and Neuroprogression Markers in Adolescents with Bipolar Disorder

Structural changes in the hippocampus and amygdala at first episode of psychosis

Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population

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