Lignosulfonate-stabilized selenium nanoparticles and their deposition on spherical silica

One of the most common prophylactic techniques to solve prosthetic joint infection (PJI) is incorporation of antibiotics into acrylic bone cement to prevent bacterial colonization and proliferation by providing local antibiotic delivery directly at the implant site. Further, there has been a significant concern over the efficacy of commonly used antibiotics within bone cement due to the rise in multi-drug resistant (MDR) microorganisms. Selenium is an essential trace element that has multiple beneficial effects for human health and its chemotherapeutic action is well known. It was reported that nanostructured selenium enhanced bone cell adhesion and has an increased osteoblast function. In this context, we used the selenium nanoparticles (SeNPs) to improve antibacterial and antioxidant properties of poly (methyl methacrylate) (PMMA) and tri calcium phosphate (TCP)-based bone cements, and to reduce of the infection risk caused by orthopedic implants. As another novelty of this study, we proposed phosphatidylcholine (PC) as a unique and natural stabilizer in the synthesis of selenium nanoparticles. After the structural analysis of the prepared bone cements was performed, in vitro osteointegration and antibacterial efficiency were tested using MC3T-E1 (mouse osteoblastic cell line) and SaOS-2 (human primary osteogenic sarcoma) cell lines, and S. aureus (Gram positive) and E.coli (Gram negative) strains, respectively. More importantly, PC-SeNPs-reinforced bone cements exhibited significant effect against E. coli, compared to S. aureus and a dose-dependent antibacterial activity against both bacterial strains tested. Meanwhile, these bone cements induced the apoptosis of SaOS-2 through increased reactive oxygen species without negatively influencing the viability of the healthy cell line. Furthermore, the obtained confocal images revealed that PC-SeNPs (103.7 ± 0.56 nm) altered the cytoskeletal structure of SaOS-2 owing to SeNPs-induced apoptosis, when MC3T3-E1 cells showed a typical spindle-shaped morphology. Taken together, these results highlighted the potential of PC-SeNPs-doped bone cements as an effective graft material in bone applications.

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“…that the zeta potential of SeNPs synthesized in presence of stabilizing agent decreased with increasing pH. 33…”

Section: Resultsmentioning

confidence: 93%

In vitro evaluation of bone cements impregnated with selenium nanoparticles stabilized by phosphatidylcholine (PC) for application in bone

Karahaliloğlu

Kılıçay

2020

J Biomater Appl

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“…[116] The ability of lignin to stabilize metal NP dispersions is related to the polyelectrolyte layer formed on the surface of metal NPs. [117,118] However, it is not clear which are the most suitable charged groups, net surface charge, and molecular weight distribution of lignin in this application.…”

Section: Materials For Heterogeneous Catalysis and Photocatalysismentioning

confidence: 99%

“…Lignin‐capped palladium NPs were used to catalyze cross‐coupling reactions in water with good selectivities, indicating that the presence of lignin does not impede catalytic activity of metal NPs . The ability of lignin to stabilize metal NP dispersions is related to the polyelectrolyte layer formed on the surface of metal NPs . However, it is not clear which are the most suitable charged groups, net surface charge, and molecular weight distribution of lignin in this application.…”

Section: Materials and Applicationsmentioning

confidence: 99%

Lignin–Inorganic Interfaces: Chemistry and Applications from Adsorbents to Catalysts and Energy Storage Materials

2020

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Lignin is one the most fascinating natural polymers due to its complex aromatic‐aliphatic structure. Phenolic hydroxyl and carboxyl groups along with other functional groups provide technical lignins with reactivity and amphiphilic character. Many different lignins have been used as functional agents to facilitate the synthesis and stabilization of inorganic materials. Herein, the use of lignin in the synthesis and chemistry of inorganic materials in selected applications with relevance to sustainable energy and environmental fields is reviewed. In essence, the combination of lignin and inorganic materials creates an interface between soft and hard materials. In many cases it is either this interface or the external lignin surface that provides functionality to the hybrid and composite materials. This Minireview closes with an overview on future directions for this research field that bridges inorganic and lignin materials for a more sustainable future.

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Section: Classification Of Hybrid Materialsunclassified

“…W literaturze odnaleźć można prace naukowe, w których materiały hybrydowe z udziałem ligniny znalazły zastosowanie w elektrochemii [18,29,30,35,43,47,59]. Szczególną rolę odgrywa w tych badaniach metodyka aktywacji ligniny z użyciem wybranych utleniaczy, dzięki czemu, biopolimer wykazuje zwiększoną obecność ugrupowań chinonowych, umożliwiających wykorzystanie takich układów w czujnikach elektrochemicznych [29,35,43] czy sensorach i/lub biosensorach [18]. Ważnym zastosowaniem jest ponadto użycie nieorganicznoorganicznych materiałów hybrydowych z udziałem ligniny w roli proekologicznych napełniaczy polimerów (polipropylenu (PP) [31,37,38,51,55], polietylenu (PE) [48,50,54,56], poli(chlorku winylu) -PVC [33,40] oraz polilaktydu (PLA) [36]).…”

Section: Classification Of Hybrid Materialsunclassified

Funkcjonalne Materiały Otrzymywane Z Udziałem Ligniny – Od Projektowania Do Zastosowania

Kłapiszewski¹

2021

WiadChem

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Wprowadzenie 1. Lignina -najważniejsze informacje i zastosowanie 2. Materiały hybrydowe -projektowalne układy obecnych czasów Uwagi końcowe Podziękowania Piśmiennictwo cytowane Dr hab. inż. Łukasz Klapiszewski, prof. PP, absolwent Wydziału Technologii Chemicznej Politechniki Poznańskiej (2010). W roku 2014 uzyskał stopień naukowy doktora nauk chemicznych w zakresie technologii chemicznej, a w 2019 stopień doktora habilitowanego w dziedzinie nauk ścisłych i przyrodniczych, dyscyplina nauki chemiczne.

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Lignosulfonate-stabilized selenium nanoparticles and their deposition on spherical silica

Cited by 33 publications

References 26 publications

In vitro evaluation of bone cements impregnated with selenium nanoparticles stabilized by phosphatidylcholine (PC) for application in bone

In vitro evaluation of bone cements impregnated with selenium nanoparticles stabilized by phosphatidylcholine (PC) for application in bone

Lignin–Inorganic Interfaces: Chemistry and Applications from Adsorbents to Catalysts and Energy Storage Materials

Funkcjonalne Materiały Otrzymywane Z Udziałem Ligniny – Od Projektowania Do Zastosowania

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