Lignin valorization for protocatechuic acid production in engineered <i>Saccharomyces cerevisiae</i>

Zhang, Ren-Kuan; Tan, Yong-Shui; Cui, You-Zhi; Xin, Xin; Liu, Zhihua; Li, Bingzhi; Yuan, Ying‐Jin

doi:10.1039/d1gc01442k

Cited by 40 publications

(23 citation statements)

References 59 publications

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“…Synthetic biology aims to redesign metabolic pathways and broaden the spectrum of products (e.g., protocatechuic acid, paclitaxel, opioids) ( Guan et al, 2020 ; Tong et al, 2021 ; Zhang et al, 2021 ). However, the new substrates and products usually affect the performance of these artificial cell factories.…”

Section: Adaptation To Improve Microbial Performancementioning

confidence: 99%

“…With the help of synthetic biology, microorganisms will produce around 30% of chemicals, biofuels and materials from renewable resources by 2030 ( Lee et al, 2019 ; Yuan and Alper, 2019 ; Zeng, 2019 ; Zhang et al, 2021 ). However, microorganisms face complex and diverse substrates and harmful conditions during the production process, severely limiting the widespread use of microbial production in renewable energy ( Huang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Microbial Adaptation to Enhance Stress Tolerance

et al. 2022

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Microbial cell factories have been widely used in the production of various chemicals. Although synthetic biology is useful in improving the cell factories, adaptation is still widely applied to enhance its complex properties. Adaptation is an important strategy for enhancing stress tolerance in microbial cell factories. Adaptation involves gradual modifications of microorganisms in a stressful environment to enhance their tolerance. During adaptation, microorganisms use different mechanisms to enhance non-preferred substrate utilization and stress tolerance, thereby improving their ability to adapt for growth and survival. In this paper, the progress on the effects of adaptation on microbial substrate utilization capacity and environmental stress tolerance are reviewed, and the mechanisms involved in enhancing microbial adaptive capacity are discussed.

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Section: Adaptation To Improve Microbial Performancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbial Adaptation to Enhance Stress Tolerance

et al. 2022

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“…In addition, extracted lignin from sweet sorghum bagasse is also a potentially raw material to produce other desired chemicals. For instance, a published case showed that protocatechuic acid was produced from lignin valorization by an engineered S. cerevisiae [ 125 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Conversion sweet sorghum biomass to produce value-added products

Zhou

Chen

2022

Biotechnol Biofuels

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Currently, most biotechnological products are produced from sugar- or starch-containing crops via microbial conversion, but accelerating the conflict with food supply. Thus, it has become increasingly interesting for industrial biotechnology to seek alternative non-food feedstock, such as sweet sorghum. Value-added chemical production from sweet sorghum not only alleviates dependency and conflict for traditional starch feedstocks (especially corn), but also improves efficient utilization of semi‐arid agricultural land resources, especially for China. Sweet sorghum is rich in components, such as fermentable carbohydrates, insoluble lignocellulosic parts and bioactive compounds, making it more likely to produce value-added chemicals. Thus, this review highlights detailed bioconversion methods and its applications for the production of value-added products from sweet sorghum biomass. Moreover, strategies and new perspectives on improving the production economics of sweet sorghum biomass utilization are also discussed, aiming to develop a competitive sweet sorghum-based economy.

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“…The synthesis of coumarins can also be produced from aromatic compounds derived from lignin by pretreatment [ 37 , 38 ]. For example, two major monomers, p -coumaric acid and ferulic acid, can be generated in alkaline hydrolysate from pretreatment and used for the biosynthesis of scopoletin.…”

Section: Biosynthesis Pathway Of Scopoletinmentioning

confidence: 99%

Advances in biosynthesis of scopoletin

Liu

et al. 2022

Microb Cell Fact

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Scopoletin is a typical example of coumarins, which can be produced in plants. Scopoletin acts as a precursor for pharmaceutical and health care products, and also possesses promising biological properties, including antibacterial, anti-tubercular, anti-hypertensive, anti-inflammatory, anti-diabetic, and anti-hyperuricemic activity. Despite the potential benefits, the production of scopoletin using traditional extraction processes from plants is unsatisfactory. In recent years, synthetic biology has developed rapidly and enabled the effective construction of microbial cell factories for production of high value-added chemicals. Herein, this review summarizes the progress of scopoletin biosynthesis in artificial microbial cell factories. The two main pathways of scopoletin biosynthesis are summarized firstly. Then, synthetic microbial cell factories are reviewed as an attractive improvement strategy for biosynthesis. Emerging techniques in synthetic biology and metabolic engineering are introduced as innovative tools for the efficient synthesis of scopoletin. This review showcases the potential of biosynthesis of scopoletin in artificial microbial cell factories.

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Lignin valorization for protocatechuic acid production in engineered Saccharomyces cerevisiae

Abstract: A biological funnel pathway was established for the production of protocatechuic acid from lignin in engineered Saccharomyces cerevisiae.

Cited by 40 publications

References 59 publications

Microbial Adaptation to Enhance Stress Tolerance

Microbial Adaptation to Enhance Stress Tolerance

Conversion sweet sorghum biomass to produce value-added products

Advances in biosynthesis of scopoletin

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