Lignans of the bark of Syringa volgaris

Куркин, В. А.; Grinenko, N. A.; Zapesochnaya, G. G.

doi:10.1007/bf00629924

Cited by 5 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comparison of 5's NMR data (Table 1) with those reported by Machida et al [9] led to the identification of 5 as (7S,8R)-5methoxydehydro-diconiferyl alcohol-4-O--D-glucopyranoside. The NMR data of 6 (Table 1) were superimposable with those reported for 4-O-lariciresinol-glucoside [10] Cytotoxicity of lignans can be associated with different mechanisms such as topoisomerase II inhibition, anti-tubulin, oestregonic and anti-angiogenic effects. Since compound 6 exhibits a selective and potent cytotoxicity compared to the positive control doxorubicin, further studies are warranted to investigate its toxicity against different cancer cell lines as well as its mechanism of action.…”

supporting

confidence: 67%

Secondary Metabolites from Astragalus lycius and Their Cytotoxic Activities

Horo

Kocabaş

Alankuş-Çalışkan

et al. 2016

Natural Product Communications

View full text Add to dashboard Cite

O-β-D-glucopyranoside (8) by spectroscopic methods including 1 Hand 13 C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 M concentration.

show abstract

supporting

confidence: 67%