Lignans from the stem bark of Syringa pinnatifolia

Effects of Phytochemically Characterized Extracts From Syringa vulgaris and Isolated Secoiridoids on Mediators of Inflammation in a Human Neutrophil Model

“…The presence of phenyl ethanoids 31 , 36 , 49 , and secoiridoids 28 , 38 , 46 , 53 , 54 , 55 , 60 as major compounds seems to be specific to this species, while lignans are more characteristic of S . pinnatifolia (Su et al, 2016 ), and secoiridoids named safghanosides are more characteristic of S . afghanica (Takenaka et al, 2002 ).…”

Chemical Profile, Cytotoxic Activity and Oxidative Stress Reduction of Different Syringa vulgaris L. Extracts

“…Scientific data on the species support the uses that are cited in traditional medicine, being connected to the antioxidant [ 10 , 11 ], antimicrobial [ 12 ], anti-inflammatory [ 13 , 14 ] and antipyretic properties [ 4 , 5 ] and inhibitory effects on blood stasis [ 15 ]. Studies were performed on similar species belonging to the genus Syringa , as S. pinnatifolia [ 12 , 16 ], but the vast majority were performed on the S. vulgaris species [ 1 , 10 , 11 , 13 , 14 , 15 ]. The compounds that are responsible for these activities are sesquiterpenes [ 12 ], hydroxycinnamoyl derivatives and secoiridoids or secoiridoid glycosides [ 1 , 13 ], phenolic compounds [ 10 , 11 , 14 , 15 ], lignans [ 14 , 16 ], phenylpropanoids and iridoids [ 14 ].…”

“…Studies were performed on similar species belonging to the genus Syringa , as S. pinnatifolia [ 12 , 16 ], but the vast majority were performed on the S. vulgaris species [ 1 , 10 , 11 , 13 , 14 , 15 ]. The compounds that are responsible for these activities are sesquiterpenes [ 12 ], hydroxycinnamoyl derivatives and secoiridoids or secoiridoid glycosides [ 1 , 13 ], phenolic compounds [ 10 , 11 , 14 , 15 ], lignans [ 14 , 16 ], phenylpropanoids and iridoids [ 14 ]. Regarding vegetal medicinal products that were tested, they were represented by flowers [ 10 , 13 , 15 ], barks [ 11 , 14 , 16 ], stems [ 12 ], fruit [ 10 ], leaves [ 11 ] or all these [ 1 ].…”

“…The compounds that are responsible for these activities are sesquiterpenes [ 12 ], hydroxycinnamoyl derivatives and secoiridoids or secoiridoid glycosides [ 1 , 13 ], phenolic compounds [ 10 , 11 , 14 , 15 ], lignans [ 14 , 16 ], phenylpropanoids and iridoids [ 14 ]. Regarding vegetal medicinal products that were tested, they were represented by flowers [ 10 , 13 , 15 ], barks [ 11 , 14 , 16 ], stems [ 12 ], fruit [ 10 ], leaves [ 11 ] or all these [ 1 ]. Nevertheless, information on this species, on its medicinal uses and on the compounds that are responsible for these uses remain scarce [ 1 ].…”

Identification of suitable reference genes for studies of Syringa pinnatifolia Hemsl.

“…pinnatifolia have isolated and identified a variety of chemical compounds, including new lignans [4,5] and sesquiterpenes [6–9], as well as compounds known from other plants [10,11]. A number of these compounds, acquired from different tissues, exhibit pharmacological effects, including antibacterial [6,10], anti‐inflammatory [10,12], antioxidant [4,8], antitumor [13], and cardioprotective [10] effects. The main compounds responsible for the pharmacological properties of S. pinnatifolia are the lignans and terpenes, with the sesquiterpenes showing the strongest effects.…”