Lignans from the fruits of Forsythia suspensa

Piao, Xiang‐Lan; Jang, Moon Hee; Cui, Jian; Piao, Xiangshu

doi:10.1016/j.bmcl.2008.01.115

Cited by 93 publications

(70 citation statements)

References 16 publications

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“…A number of pharmacological activities of these four marker components were previously reported [5][6][7]. However, only phillyrin was selected as quantitative constituent for Forsythia suspensa in Chinese Pharmacopoeia 2005 [3].…”

Section: Quantitative Analysis Of Marker Componentsmentioning

confidence: 99%

“…Four marker components, pinoresinol-b-D-glucoside, forsythiaside, phillyrin and phillygenin, have obvious biological activity such as antiviral effects, antioxidant and antiinflammatory [5][6][7], and can integrally express the quality of FSE. So, taking four marker components as the four variables (X 1 , X 2 , X 3 and X 4 ), we established BDA functions to distinguish the different FSE.…”

Section: Quality Evaluation By Bdamentioning

confidence: 99%

“…According to the maturity level of its fruits, the commercial drugs could be classified into ''Qingqiao'' (immature) and ''Laoqiao'' (mature), both of which are official sources of this TCM [3]. Lianqiao has been widely used as an antipyretic, detoxicant and anti-inflammatory agent for the treatment of various infectious diseases [5,6]. It has also been shown that Forsythia suspensa extract (FSE) is able to suppress vomiting, resist hepatic injury and strengthen antioxidant, antiendotoxin and antiviral effects [7].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector

Xia

Yang

Wang

et al. 2009

J of Separation Science

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A simple and reproducible HPLC-photodiode array detector method has been described for evaluating and controlling quality of Forsythia suspensa extract (FSE). First, by analysis of chromatographic fingerprints, the similarities of chromatograms of FSE samples from the same pharmaceutical company exceeded 0.999, 0.997 and 0.960, respectively, although they were much lower from different pharmaceutical companies. Second, by further comparing many batches of extract chromatograph charts with the corresponding reference herb materials, the ''common peaks'' 3, 5, 7 and 10 were defined as ''marker peaks'', which were identified as (1)-pinoresinol-b-D-glucoside, forsythiaside, phillyrin and phillygenin, respectively. Third, four ''marker peaks'' were simultaneously determined based on fingerprint chromatogram for further controlling the quality of FSE quantitatively. Namely, the newly developed method was successfully applied to analyze 38 batches of FSE samples supplied by three pharmaceutical factories, which showed acceptable linearity, intra-day precision (RSDo2.76%), inter-day precision (RSDo3.43%) and the average recovery rates in the range of (95.3872.96)% to (101.6073.08)%. At last, hierarchical clustering analysis and Bayes discriminant analysis statistical methods were used to classify and differentiate the 38 FSE samples to provide the basis for guiding reasonable use of FSE and controlling its quality better.

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Section: Quantitative Analysis Of Marker Componentsmentioning

confidence: 99%

Section: Quality Evaluation By Bdamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector

Xia

Yang

Wang

et al. 2009

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…Phillyrin was reported to have various biological activities such as antioxidant, anti-infl ammatory, anti-hyperlipidemia and antipyretic activities (Qu et al, 2008). Studies on phillyrin have shown its presence mainly in the leaves and fruits of the plant F. suspensa (Piao et al, 2008).…”

Section: Forsythia Suspensa (Thunb) Vahl (Oleaceae)mentioning

confidence: 99%

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Venieraki

Dimou

Katinakis

2017

Hellenic Plant Protection Journal

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SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefi ts. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very eff ective and have relatively less or no side eff ects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5x106 Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.Additional key words: metabolites from endophytic bacteria and actinomycetes, chemical ecology present in virtually all organs of a given plant host, and some are seed borne. Endophytes often confer considerable benefi ts to the host plant they inhabit, since they can promote the growth of host plants, enhance resistance to biotic and abiotic stresses (Rodriguez et al., 2009; Hardoim et al., 2015), and accumulate bioactive secondary metabolites (Kusari et al., 2012). The ecological role of secondary metabolites produced by endophytes is not clear. However, recent studies have shown that these metabolites are involved in deterrence of herbivory (Pannaccione et al., 2014), protection against fungal (Soliman et al., 2015) or bacterial pathogens (Mousa et al., 2017) and amelioration of plant abiotic stress (Hamayum et al., 2016). Bioactive secondary metabolites derived from medicinal plants are gradually decreasing -Alternative approaches for their productionMedicinal plants, as a rich source of nat-

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“…Vahl, is a widely distributed climbing plant and an important traditional Chinese medicine [11]. It has significant antiviral, antibacterial, antioxidant, and anti-inflammatory activities [12,13]. Lignans, phenylethanoid glycosides, flavonoids, volatile oils, and terpenes have all been extracted from the plant, among which forsythiaside A, forsythiaside B, and phillyrin are thought to be the main bioactive constituents.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage

Jin¹,

Zhao²,

Yuan³

et al. 2014

JFNR

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Chronic exposure to ultraviolet (UV) radiation affects diverse constituents of skin and induces photoaging. Current therapeutic approaches cannot fully reverse the pathophysiology of photoaging, thus necessitating the discovery of new strategies to protect skin from UV radiation. Natural products have long been reported to possess photoprotective effects. Herein, we investigated the potential anti-UVA effects of forsythiaside A, forsythiaside B, and phillyrin extracted from Forsythia suspensa (Thunb.) Vahl. In vitro, all three compounds significantly prevented cytotoxicity, DNA damage, apoptosis, and cell-cycle arrest caused by a low dose of UVA. All three compounds also inhibited the expression of inflammatory cytokines. Collectively, our results suggest that these three compounds could be preventives against UVA-induced skin damage.

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Lignans from the fruits of Forsythia suspensa

Cited by 93 publications

References 16 publications

Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector

Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

Protective Effects of Forsythiaside A, Forsythiaside B, and Phillyrin against UVA-Induced Cell Damage

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