Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells

Le, Duc Dat; Zhao, Bing; Hùng, Nguyễn Đức; Lee, Jeong Hyung; Min, Byung Sun; Woo, Mi Hee

doi:10.1016/j.bmcl.2016.12.028

Cited by 25 publications

(7 citation statements)

References 26 publications

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“…isolated compounds (1-24) on the viability of RAW 264.7 macrophage cells To obtain a suitable concentration range for investigating the effects of the isolated compounds (1-24) on RAW 264.7 cell viability, cells were treated with concentrations ranging from 3 to 50 µM and later treated with LPS (1 µg/mL) for 24 h using MTT assay. 14) There were no significant alterations in cell viability following EP extract treatment at these concentrations (data not shown). Table 1).…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 85%

“…Fatty acid may upregulate lipid metabolism of diabetes and insulin sensitivity, decrease the incidence of obesity, facilitate weight loss, and help maintenance of body weight. 32) Additionally, saponin compounds (12)(13)(14)(15) group at C-7 showed the strongest inhibitory effect in isoflavone series (8)(9)(10). Similarity, compound 7 having a methoxyl group showed the strongest PTP1B inhibitory activity among flavones (1-7).…”

Section: Ptp1b Inhibitory Activity Of Isolates (1-24) From E Prostramentioning

confidence: 93%

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PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

Nguyen

Sook

et al. 2021

Biological & Pharmaceutical Bulletin

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Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 85%

Section: Ptp1b Inhibitory Activity Of Isolates (1-24) From E Prostramentioning

confidence: 93%

PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

Nguyen

Sook

et al. 2021

Biological & Pharmaceutical Bulletin

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“…LPS stimulated macrophages trigger the secretion of cytokines and mediators, and upon treatment with LPS, RAW 264.7 cells produce induced NO and PGE 2 as well as other inflammatory cytokines (Le et al. 2017 ). NO is an important inflammatory product produced by iNOS and is primarily involved in promoting inflammatory responses.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effect of pomegranate flower in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages

Zhang

Aisa

2017

Pharmaceutical Biology

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Context:Punica granatum L (Punicaceae) flower is an important diabetes treatment in oriental herbal medicine.Objective: This study investigates the inflammation effects of pomegranate flower (PFE) ethanol extract in LPS-induced RAW264.7 cells.Materials and methods: PFE (10, 25, 50, 100 μg/mL) was applied to 1 μg/mL LPS-induced RAW 264.7 macrophages in vitro. Levels of nitric oxide (NO), prostaglandin E2 (PGE2) and pro-inflammatory cytokines interleukin (IL)-1β (IL-1β), interleukin (IL)-6 (IL-6) and tumor necrosis factor (TNF-α) in the supernatant fraction were determined using enzyme-linked immunosorbent assay (ELISA). Expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), phosphorylation of mitogen-activated protein kinase (MAPK) subgroups extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and P38, as well as nuclear factor-κB (NF-κB) activation in extracts were detected via Western blot.Results: 10–100 μg/mL PFE decreased the production of NO (IC50 value = 31.8 μg/mL), PGE2 (IC50 value = 54.5 μg/mL), IL-6 (IC50 value = 48.7 μg/mL), IL-1β (IC50 value = 71.3 μg/mL) and TNF-α (IC50 value = 62.5 μg/mL) in LPS-stimulated RAW 264.7 cells significantly. A mechanism-based study showed that phosphorylation of ERK1/2, p38, JNK and translocation of the NF-B p65 subunit into nuclei were inhibited by the PFE treatment.Discussion and conclusion: These results show that PFE produced potential anti-inflammatory effect through modulating the synthesis of several mediators and cytokines involved in the inflammatory process.

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“…As one member of the Selaginella genus, Selaginella tamariscina (Beauv.) spring is a herbal medicine that is commonly used to treat cancer, hepatitis, and diabetes, and is widely used in clinical practice [5–8]. In particular, S .…”

Section: Introductionmentioning

confidence: 99%

Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress

Zhang

Sun

et al. 2019

PLoS ONE

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Selaginella tamariscina (Beauv.) spring, a primitive vascular resurrection plant, can survive extreme drought and recover when water becomes available. To identify drought-inducible genes and to clarify the molecular mechanism of drought tolerance, a comparative transcriptional pattern analysis was conducted between S. tamariscina and Selaginella moellendorffii Hieron (drought sensitive). 133 drought related genes were identified, including 72 functional genes and 61 regulatory genes. And several drought responsive reactions, such as antioxidant activity, osmotic balance, cuticle defense and signal transduction were highlighted in S. tamariscina under drought. Notably, besides peroxidase, catalase and L-ascorbate oxidase genes, DEGs associated with phenylalanine metabolism and polyamine catabolism could be alternative ways to enhance antioxidant ability in S. tamariscina. DEGs related to soluble carbohydrate metabolism, late embryogenesis abundant protein (LEA) and aquaporin protein (AQP) confirmed that osmotic adjustment could resist drought during desiccation. DEGs involved in xyloglucan metabolic process, pectin metabolic process and cutin biosynthesis may also contribute to drought tolerance of S. tamariscina by cuticle defense. Drought-responsive genes encoding protein kinases, calcium sensors, transcription factors (TFs) and plant hormones also help to drought resistance of S. tamariscina. The preliminary validation experiments were performed and the results were consistent with our hypothetical integrated regulatory network. The results of this study provide candidate resurrection genes and an integrated regulatory network for further studies on the molecular mechanisms of stress tolerance in S. tamariscina.

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Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells

Cited by 25 publications

References 26 publications

PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.

Anti-inflammatory effect of pomegranate flower in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages

Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress

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