“Lighting up” fluoride: cellular imaging and zebrafish model interrogations using a simple ESIPT-based mycophenolic acid precursor-based probe

Abstract

The discovery and implementation of media that derive from bioinspired designs and bear optical readouts featuring large Stokes shifts are of continued interest to a wide variety of researchers and clinicians.

Highly sensitive and rapid detection of hypochlorous acid in aqueous media and its bioimaging in live cells and zebrafish using an ESIPT-driven mycophenolic acid-based fluorescent probe

“…Thus we believe that Myco-OCl detects HOCl through the ESIPT chemical rearrangement that results in a fluorescence turn-on cascade. 49…”

Computational Insights into Excited State Intramolecular Double Proton Transfer Behavior Associated with Atomic Electronegativity for Bis(2′-benzothiazolyl)hydroquinone

“…There is no denying that applications toward chemical sensing should be by far the most important aspect of ESIPT probes, which has been demonstrated in the detection of environmental molecules and biomolecules [ 11 , 12 , 13 , 14 ]. As we all know, multi-hydrogen bonds cannot be avoided in practical applications—especially in real environments or in vivo.…”

A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift

“…19 ESIPT fluorophores have large Stokes shifts, which can avoid self-absorption and inner-filter effects; hence ESIPT-based fluorescent probes have been extensively studied. 20–27 Phthalimide derivatives are the typical representative of ESIPT fluorescent dyes with the merits of simple synthesis, good photostability, high quantum yield, large Stokes shift, and biocompatibility. 21–27 Currently, phthalimide-based fluorescent probes have been utilized to detect carbon monoxide (CO), 21 S -nitrosoglutathione (GSNO), 22 hydrogen peroxide (H 2 O 2 ), 23 palladium, 24 copper ions, 25 fluoride ion (F − ), 26 and peroxynitrite (ONOO − ).…”

“…20–27 Phthalimide derivatives are the typical representative of ESIPT fluorescent dyes with the merits of simple synthesis, good photostability, high quantum yield, large Stokes shift, and biocompatibility. 21–27 Currently, phthalimide-based fluorescent probes have been utilized to detect carbon monoxide (CO), 21 S -nitrosoglutathione (GSNO), 22 hydrogen peroxide (H 2 O 2 ), 23 palladium, 24 copper ions, 25 fluoride ion (F − ), 26 and peroxynitrite (ONOO − ). 27 However, as far as we know, phthalimide-based Hg 2+ -specific fluorescent probes have not yet been reported.…”