A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg²⁺ with large Stokes shift

Abstract

1 is the first mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift, rapid response, and high sensitivity and selectivity.

Naphthalimide‐based fluorescent probe for Hg2+ detection and imaging in living cells and zebrafish

“…If combined with fluorescence imaging, the organic fluorescent probe has many advantages in detecting ions, such as its fast response time, high selectivity and sensitivity, and the real‐time and online detection ability [14, 15]. The improvement of optic probes systems to detect Hg 2+ is mainly attracted because they are of enormous significance in many scientific areas such as environmental chemical and biological researches [16, 17]. Thus, various fluorescent probes have been designed and synthesized for Hg 2+ detection based on coordination mechanism.…”

“…Naphthalimide structure has excellent optical properties and an easily fine‐tuned structure, which makes it easy to apply in many areas [18‐20]. Its absorption and fluorescence emission spectra located within the ultraviolet (UV) and visible regions and its aromatic ‘naphthalene’ moiety and ‘N‐imide site’ in the naphthalimide structure allow it to be modified into a variety of compounds with excellent properties [21, 22].…”

Screening the Optimal Probe by Expounding the ESIPT Mechanism and Photophysical Properties in Bis-HBX with Multimodal Substitutions

“…In the 1950s, Weller first observed the double fluorescence phenomenon during an experimental study on the dynamic characteristics of methyl salicylate and attributed it to the ESIPT reaction [ 9 ]. Since then, the mechanism of the ESIPT reaction has attracted the attention of extensive researchers, most of whom have studied it experimentally and theoretically [ 10 , 11 , 12 , 13 ].…”