“…Elevated body temperature at night, a time when thermoregulatory cooling responses are important for sleep onset and sleep quality (Raymann et al, 2005 , 2008 ; Romeijn et al, 2011 ), is the most consistently observed circadian abnormality in depression (Avery et al, 1982b ; Souetre et al, 1988 ; Duncan, 1996 ), an abnormality that typically normalizes with clinical improvement, (e.g., following ECT, antidepressant drug treatment or spontaneous recovery) (Avery et al, 1982a , b ). Although not observed in all studies, a phase advance in the 24-h pattern of body temperature has also been described in some depressed patients (Dietzel et al, 1986 ; Goetze and Tolle, 1987 ; Souetre et al, 1988 ; Parry et al, 1989 ). Interestingly, despite the higher nocturnal temperature in depressed patients, there is no concomitant increase in nighttime sweating (Avery et al, 1999 ).…”