Abstract"Warmth" is the most powerful personality trait in social judgment, and attachment theorists have stressed the importance of warm physical contact with caregivers during infancy for healthy relationships in adulthood. Intriguingly, recent research in humans points to the involvement of the insula in the processing of both physical temperature and interpersonal warmth (trust) information. Accordingly, we hypothesized that experiences of physical warmth (or coldness) would increase feelings of interpersonal warmth (or coldness), without the person's awareness of this influence. In study 1, participants who briefly held a cup of hot (versus iced) coffee judged a target person as having a "warmer" personality (generous, caring); in study 2, participants holding a hot (versus cold) therapeutic pad were more likely to choose a gift for a friend instead of for themselves.Ever since Solomon Asch's(1) original demonstration of the transformational power of "warm" and "cold" as personality traits in first impressions of individuals, the concept of psychological warmth has been prominently featured in research on social perception and interpersonal liking (2-4). The warm-cold dimension has emerged as one of two main components of the first impressions (along with competence) we quickly form of other people (2,5); together they account for a large proportion (82%) of the variance in people's evaluations of social behaviors (6). Notably, the warmth and competence dimensions have been found to be the principal ones underlying every group stereotype studied across dozens of countries (2,5). Of these two fundamental dimensions, warmth is primary, as "people are more sensitive to warmth information than to competence information" (5, p. 79) and make trustworthiness judgments of faces faster than for other traits, including competence (7).What does it mean, exactly, to perceive someone as a "warm" versus a "cold" person? According to recent theory and research in social cognition, interpersonal warmth refers to a constellation of traits related to perceived favorability of the other person's intentions toward us, including friendliness, helpfulness, and trustworthiness (5). The warm-cold assessment is the social perceiver's immediate "first-pass" as to whether the target individual (or social group) can be trusted as a friend (7), or at least as a "non-foe" (i.e., warm), or is instead a potential foe who might attempt to interfere with one's ongoing goal pursuits (i.e., cold). [The competence assessment is then a "second-pass" evaluation of whether the newly encountered individual (or group) has the capacity to act on those perceived intentions (5).] This assessment

It has long been a staple of psychological theory that early life experiences significantly shape the adult's understanding of and reactions to the social world. Here we consider how early concept development along with evolved motives operating early in life can come to exert a passive, unconscious influence on the human adult's higher-order goal pursuits, judgments, and actions. In particular, we focus on concepts and goal structures specialized for interacting with the physical environment (e.g., distance cues, temperature, cleanliness, and self-protection), which emerge early and automatically as a natural part of human development and evolution. It is proposed that via the process of scaffolding, these early sensorimotor experiences serve as the foundation for the later development of more abstract concepts and goals. Experiments using priming methodologies reveal the extent to which these early concepts serve as the analogical basis for more abstract psychological concepts, such that we come easily and naturally to speak of close relationships, warm personalities, moral purity, and psychological pain. Taken together, this research demonstrates the extent to which such foundational concepts are capable of influencing people's information processing, affective judgments, and goal pursuit, oftentimes outside of their intention or awareness.

Yttrium-90 microsphere brachytherapy of the liver exploits the distinctive features of the liver anatomy to treat liver malignancies with beta radiation and is gaining more wide spread clinical use. This report provides a general overview of microsphere liver brachytherapy and assists the treatment team in creating local treatment practices to provide safe and efficient patient treatment. Suggestions for future improvements are incorporated with the basic rationale for the therapy and currently used procedures. Imaging modalities utilized and their respective quality assurance are discussed. General as well as vendor specific delivery procedures are reviewed. The current dosimetry models are reviewed and suggestions for dosimetry advancement are made. Beta activity standards are reviewed and vendor implementation strategies are discussed. Radioactive material licensing and radiation safety are discussed given the unique requirements of microsphere brachytherapy. A general, team-based quality assurance program is reviewed to provide guidance for the creation of the local procedures. Finally, recommendations are given on how to deliver the current state of the art treatments and directions for future improvements in the therapy.

Trust lies at the heart of person perception and interpersonal decision making. In two studies, we investigated physical temperature as one factor that can influence human trust behavior, and the insula as a possible neural substrate. Participants briefly touched either a cold or warm pack, and then played an economic trust game. Those primed with cold invested less with an anonymous partner, revealing lesser interpersonal trust, as compared to those who touched a warm pack. In Study 2, we examined neural activity during trust-related processes after a temperature manipulation using functional magnetic resonance imaging. The left-anterior insular region activated more strongly than baseline only when the trust decision was preceded by touching a cold pack, and not a warm pack. In addition, greater activation within bilateral insula was identified during the decision phase followed by a cold manipulation, contrasted to warm. These results suggest that the insula may be a key shared neural substrate that mediates the influence of temperature on trust processes.

People often encounter difficulty when making conscious attempts to regulate their emotions. We propose that nonconscious self-regulatory processes may be of help in these difficult circumstances, because nonconscious processes are not subject to the same set of limitations as are conscious processes. Two experiments examined the effects of nonconsciously operating goals on people's emotion-regulatory success. In Experiment 1, participants engaged in an anxiety-eliciting task who had a reappraisal emotion-control goal primed and operating nonconsciously achieved the same decrease in physiological reactivity as those explicitly instructed to reappraise, compared to a control group. In Experiment 2, the effect of nonconscious reappraisal priming on physiological reactivity was shown to be most pronounced for those who do not habitually use reappraisal strategies. The findings highlight the potential importance of nonconscious goals for facilitating emotional control in complex real-world environments, and have implications for contemporary models of emotion-regulation.

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We have recently described the in vivo properties of an iodinated anti-p185 HER2 engineered antibody fragment [minibody (scFv-C H 3) 2 ; 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to the target in vitro, only modest tumor uptake [5.6 F 1.7% injected dose per gram (ID/g) of tissue] was achieved in nude mice bearing MCF7/HER2 breast cancer tumors. Here, in an attempt to improve targeting, the 10H8 minibody was conjugated to 1,4,7,10-tetraazacyclododecane-N , N V , N V V , N